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Janice Ser Huey Tan Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Timothy Kwang Yong Tay Department of Pathology, Singapore General Hospital, Singapore

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Enya Hui Wen Ong Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Michael Fehlings ImmunoScape, 1 Scotts Road #24-10, Singapore

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Daniel Shao-Weng Tan Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Nadiah Binte Sukma Department of Pathology, Singapore General Hospital, Singapore

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Eileen Xueqin Chen Department of Pathology, Singapore General Hospital, Singapore

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Jen-Hwei Sng Department of Pathology, Singapore General Hospital, Singapore

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Connie Siew Poh Yip Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Kok Hing Lim Department of Pathology, Singapore General Hospital, Singapore

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Darren Wan-Teck Lim Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Narayanan Gopalakrishna Iyer Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Jacqueline Siok Gek Hwang Department of Pathology, Singapore General Hospital, Singapore

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Melvin Lee Kiang Chua Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Mei-Kim Ang Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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a case series of five patients with ATC who underwent a combinatorial regimen of sandwich sequencing of pembrolizumab and accelerated hypofractionated RT (QUAD-shot). We demonstrate that such a combination was able to achieve a high ORR, resulting in

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