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needle aspirates can be used to infer the risk of malignancy in indeterminate thyroid nodules ( 6 , 7 , 8 ) and for genetic analysis in other types of cancers such as pancreatic cancers ( 9 ). For thyroid cancer patients, when FFPE tumoral tissue is
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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/hormone synthesis ( 4 , 5 , 6 , 7 , 8 , 9 ). At variance with most other thyroid nodules, current textbooks and guidelines assess HTN as a low cancer risk with no further malignancy evaluation recommended ( 10 ). To understand the role of TSHR signaling in
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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tumor suppressor, and SIRT4 is downregulated in several malignancies including thyroid cancer ( 14 , 15 ). However, the precise function of SIRT4 in cancer remains unclear, and its involvement in cancer development has been suggested ( 12 , 16
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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germline mutation ( 1 , 2 ). Patients with MTC have a high risk of developing distant metastases. Up to 23% of patients present with lymph nodes or distant metastases at the time of diagnosis, which is the main reason for MTC-related death. Therefore