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Joke Marlier Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Guy T’Sjoen Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Jean Kaufman Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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Bruno Lapauw Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium

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puts patients with CHT at greater risk for inappropriate substitution compared to patients with PHT. Though poorly investigated, it is likely that CHT can significantly affect quality of life (QoL) at all ages ( 1 ) and that at least part of this may

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Jacqueline Jonklaas Division of Endocrinology, Georgetown University, Washington, District of Columbia, USA

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Antonio C. Bianco Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA

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Anne R. Cappola Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Francesco S. Celi Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands

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Heike Heuer Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Elizabeth A. McAninch Division of Endocrinology, Rush University, Chicago, Illinois, USA

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Lars C. Moeller Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Birte Nygaard Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Anna M. Sawka Division of Endocrinology, University Health Network and University of Toronto, Toronto, Ontario, Canada

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Colin M. Dayan Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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-DIO2 [ 20 ]. Studies comparing human and rodents should bear in mind interspecies differences. On one hand, the rodent thyroid produces relatively more T3 than the human thyroid, theoretically placing LT4-treated hypothyroid mice at a higher risk of

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