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binding of thyroid-stimulating hormone receptor antibodies (TRAb) to thyroid-stimulating hormone (TSH) receptors leads to unregulated thyroid hormone production independent of pituitary TSH, resulting in hyperthyroidism ( 1 ). Central hyperthyroidism is a
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK
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Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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-diagnosis. We describe the detailed baseline characteristics of the cohort including the frequency of eye signs linked to thyrotoxicosis as well as initial change in BMI on ATD. We also examined the early serum thyroid-stimulating hormone (TSH) and free
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Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal
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Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal
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Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Department of Surgery and Physiology, Cardiovascular Research Unit, Faculty of Medicine from the University of Porto, Porto, Portugal
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Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal
Institute for Research Innovation in Health, University of Porto, Porto, Portugal
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outcomes The following parameters were collected from the patients’ clinical records: sex, age, age at diagnosis of Graves' disease, initial TRAbs, free tri-iodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), height, weight
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worsening of patient’s clinical and analytical condition, despite the institution of high-dose glucocorticoids, forced an increase in thionamide’s dose in an attempt to stabilize thyroid hormones’ levels, even considering its potential toxic effects which
Institute of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden
Gothenburg Centre for Person Centred-Care (GPCC), Göteborg, Sweden
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/L (reference range: 1.3–3.1) in combination with positive thyroid-stimulating hormone receptor antibodies (TRAbs) and/or a technetium scintigraphy with a diffuse uptake. Exclusion criteria were pregnancy, serious somatic disease such as other endocrine disease
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( 1 ). Several studies identified pre-treatment parameters that could help in the prediction of the thyroid functional outcome such as age, gender, thyroid gland volume, free thyroxine (fT4) and free triiodothyronine (fT3) at diagnosis, and thyroid-stimulating
Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Department of Clinical Institute, Aalborg University, Aalborg, Denmark
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Thyroid Research 2019 2019 5945178 . ( https://doi.org/10.1155/2019/5945178 ) 15 Pedersen IB Handberg A Knudsen N Heickendorff L Laurberg P . Assays for thyroid-stimulating hormone receptor antibodies employing different ligands and ligand
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-free thyroxine (FT4) (FT3/FT4) ratio was significantly higher and thyrotropin-stimulating hormone (TSH) receptor antibodies (TRAbs) were significantly lower in the TgAb+/TPOAb− group. Patients positive for TgAb developed GD with lower TRAb titers and underwent
Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Amsterdam Public Health Research Institute, Amsterdam UMC, The Netherlands
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Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands
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Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC Location Vrije Universiteit Amsterdam, Boelelaan, Amsterdam, The Netherlands
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Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Public Health Research Institute, Meibergdreef, Amsterdam, The Netherlands
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overactivity, defined by a TSH (thyroid-stimulating hormone) concentration below the reference interval with fT4 (free thyroxine; thyroid hormone) within the reference interval ( 1 ). The prevalence of subclinical hyperthyroidism ranges from 0.7% to 1.8% in
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supplementary. Clinical symptoms and signs of hyperthyroidism. Goiter confirmed by palpation or thyroid ultrasound. Decreased levels of serum thyroid-stimulating hormone (TSH) and increased levels of thyroid hormone (TH). Proptosis and