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Markus Eszlinger
Markus Eszlinger
Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany
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Alexandra Stephenson
Alexandra Stephenson
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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Shideh Mirhadi
Shideh Mirhadi
Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
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Konrad Patyra
Konrad Patyra
Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
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Michael F Moran
Michael F Moran
Program in Cell Biology, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada
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Moosa Khalil
Moosa Khalil
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Jukka Kero
Jukka Kero
Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Ralf Paschke
Ralf Paschke
Department of Oncology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada, and Institute of Pathology, University Hospital Halle, Halle, Germany
Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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Introduction Nonautoimmune hyperthyroidism (NAH) is caused by a constitutively activating thyroid stimulating hormone receptor (TSHR) germline mutation. Germline mutations in TSHR lead to sporadic and familial NAH (SNAH, FNAH) whereas somatic
Markus Eszlinger
Markus Eszlinger
Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Paul Stewardson
Paul Stewardson
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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John B McIntyre
John B McIntyre
Precision Oncology Hub Laboratory, Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Adrian Box
Adrian Box
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Moosa Khalil
Moosa Khalil
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Martin Hyrcza
Martin Hyrcza
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Konstantin Koro
Konstantin Koro
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Dean Ruether
Dean Ruether
Section of Medical Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Jiahui Wu
Jiahui Wu
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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mutation-positive medullary thyroid cancer (MTC) or RET gene fusion-positive thyroid cancer. The early approval of these drugs was based on phase 1/2 data ( 1 , 2 , 3 , 4 , 5 ). Patients with thyroid cancer were one of the larger patient groups in the
Hélène Théodon
Hélène Théodon
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Erell Guillerm
Erell Guillerm
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Johanna Wassermann
Johanna Wassermann
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Gabrielle Deniziaut
Gabrielle Deniziaut
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Loïc Jaffrelot
Loïc Jaffrelot
Department of Oncology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Jérome Denis
Jérome Denis
Department of Endocrine and Oncology Biochemistry, Sorbonne Université, Pitié-Salpêtrière Hospital, Paris, France
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Nathalie Chereau
Nathalie Chereau
Department of Endocrine Surgery, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Claude Bigorgne
Claude Bigorgne
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Wiame Potonnier
Wiame Potonnier
Department of Pathology, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Florence Coulet
Florence Coulet
Department of Oncogenetic, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Laurence Leenhardt
Laurence Leenhardt
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Camille Buffet
Camille Buffet
Department of Thyroid and Endocrine Tumors, Sorbonne Université, GRC n°16, GRC Tumeurs Thyroïdiennes, Pitié-Salpêtrière Hospital, Paris, France
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Introduction Advances in molecular genotyping with high-throughput sequencing have led to better understanding of the genetic landscape of thyroid cancer and ultimately to major improvements in the treatment of advanced thyroid cancers ( 1
Hyun-Jin Lee
Hyun-Jin Lee
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, South Korea
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Young-Sool Hah
Young-Sool Hah
Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
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So Young Cheon
So Young Cheon
Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
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Seong Jun Won
Seong Jun Won
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Chae Dong Yim
Chae Dong Yim
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Somi Ryu
Somi Ryu
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Seung-Jun Lee
Seung-Jun Lee
Department of Convergence of Medical Sciences, Gyeongsang National University, Jinju, South Korea
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Ji Hyun Seo
Ji Hyun Seo
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, South Korea
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Jung Je Park
Jung Je Park
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University College of Medicine, Jinju, South Korea
Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, South Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Gyeongsang National University Hospital, Jinju, South Korea
Institute of Health Sciences, Gyeongsang National University, Jinju, South Korea
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Introduction Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer, accounting for more than 90% of all thyroid cancers ( 1 ). PTC is generally an indolent tumor with a relatively favorable prognosis; indeed, the 10
Abdul Rehman Syed
Abdul Rehman Syed
University of Calgary, Calgary, Alberta, Canada
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Aakash Gorana
Aakash Gorana
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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Erik Nohr
Erik Nohr
Alberta Precision Laboratories, Molecular Pathology Program, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Xiaoli-Kat Yuan
Xiaoli-Kat Yuan
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Parthiv Amin MASc
Parthiv Amin MASc
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada
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Sana Ghaznavi
Sana Ghaznavi
Arnie Charbonneau Cancer Institute, Department of Medicine, Section of Endocrinology, University of Calgary, Calgary, Alberta, Canada
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Debbie Lamb
Debbie Lamb
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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John McIntyre
John McIntyre
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Markus Eszlinger
Markus Eszlinger
Department of Oncology, Cumming School of Medicine, and Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Section of Endocrinology, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Graphical abstract Introduction Papillary thyroid carcinoma (PTC) typically has an excellent clinical prognosis. However, 10% of cases of differentiated thyroid cancers (DTC) will progress to a metastatic stage after receiving initial
Joachim N Nilsson
Joachim N Nilsson
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Jonathan Siikanen
Jonathan Siikanen
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Vincenzo Condello
Vincenzo Condello
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Kenbugul Jatta
Kenbugul Jatta
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Ravi Saini
Ravi Saini
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Christel Hedman
Christel Hedman
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Catharina Ihre Lundgren
Catharina Ihre Lundgren
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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C Christofer Juhlin
C Christofer Juhlin
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Introduction Differentiated thyroid cancer is treated with surgery, and in cases of larger tumours or cervical lymph node metastases, additional hormone suppression and radioiodine therapy are given. Successful radioiodine therapy requires
Carla Colombo
Carla Colombo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Daniele Ceruti
Daniele Ceruti
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Massimiliano Succi
Massimiliano Succi
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Simone De Leo
Simone De Leo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Matteo Trevisan
Matteo Trevisan
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Claudia Moneta
Claudia Moneta
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Introduction Tyrosine kinase inhibitors (TKIs) and target therapies are efficiently used in the treatment of progressive radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) and advanced medullary thyroid cancer (MTC) ( 1 ). In
Zhaoqi Zhang
Zhaoqi Zhang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Josef Yu
Josef Yu
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Eva Rainer
Eva Rainer
Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Vienna, Austria
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Lindsay Hargitai
Lindsay Hargitai
Department of General Surgery, Medical University of Vienna, Vienna, Austria
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Zewen Jiang
Zewen Jiang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Georgios Karanikas
Georgios Karanikas
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Tatjana Traub-Weidinger
Tatjana Traub-Weidinger
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Richard Crevenna
Richard Crevenna
Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
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Marcus Hacker
Marcus Hacker
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Shuren Li
Shuren Li
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Introduction Medullary thyroid cancer (MTC) accounts for about 2% of all thyroid cancers. About 20–25% of MTC cases are hereditary, caused by a mutation in the RET proto-oncogene. However, in most cases, MTC is sporadic with no underlying
Ségolène Hescot
Ségolène Hescot
Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
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Julien Masliah-Planchon
Julien Masliah-Planchon
Department of Genetics, Institut Curie, Paris, France
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Pauline du Rusquec
Pauline du Rusquec
Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
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Célia Dupain
Célia Dupain
Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
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Maud Kamal
Maud Kamal
Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France
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Vincent Servois
Vincent Servois
Department of Radiology, Institut Curie, Paris, France
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Ivan Bieche
Ivan Bieche
Department of Genetics, Institut Curie, Paris, France
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Medullary thyroid carcinoma (MTC) is a rare but aggressive thyroid tumor, with 25% of hereditary and 75% of sporadic forms. RET mutations are found in 98% of hereditary MTC and in 55% of sporadic MTC ( 1 ). The most frequent somatic RET
Fabio Hecht
Fabio Hecht
Université Paris-Saclay, Orsay, France
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Laura Valerio
Laura Valerio
Université Paris-Saclay, Orsay, France
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Carlos Frederico Lima Gonçalves
Carlos Frederico Lima Gonçalves
Université Paris-Saclay, Orsay, France
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Marylin Harinquet
Marylin Harinquet
Université Paris-Saclay, Orsay, France
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Rabii Ameziane El Hassani
Rabii Ameziane El Hassani
Laboratoire de Biologie des Pathologies Humaines ‘BioPatH’, Université Mohammed V de Rabat, Faculté des Sciences, BP1014 Rabat, 10001, Morocco
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Denise P Carvalho
Denise P Carvalho
Laboratório de Fisiologia Endócrina Doris Rosenthal, nstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Stephane Koundrioukoff
Stephane Koundrioukoff
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
Sorbonne Université, Paris, France
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Gustave Roussy, Villejuif, France
Sorbonne Université, Paris, France
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Jean-Charles Cadoret
Jean-Charles Cadoret
Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France
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Corinne Dupuy
Corinne Dupuy
Université Paris-Saclay, Orsay, France
UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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UMR 9019 CNRS F-94805 Villejuif, France
Gustave Roussy, Villejuif, France
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Introduction Ionizing radiation (IR) leads to various delayed cellular effects, including chromosomal rearrangements, which are believed to play a key role in radiation-induced carcinogenesis. The thyroid gland is particularly sensitive to IR
