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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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, free T4; RF, rheumatoid factor; Tg-Ab, anti-thyroglobulin antibodies; TPO-Ab, anti-thyroid peroxidase antibodies; TRAb, anti-TSH receptor antibodies; TSH, thyroid-stimulating hormone. Immunometric assays, also known as ‘sandwich’ immunoassays
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Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
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the action of thyroid hormones on LDL cholesterol receptor expression, resulting in net accumulation of serum LDL cholesterol. Therefore, compared with healthy subjects, patients with hypothyroidism usually present with increased TC and LDL
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Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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. ( https://doi.org/10.1210/jc.2013-2743 ) 23 Astapova I Vella KR Ramadoss P Holtz KA Rodwin BA Liao XH Weiss RE Rosenberg MA Rosenzweig A & Hollenberg AN . The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity
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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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Regional Center for Newborn Screening, Diagnosis and Treatment of Congenital Metabolic and Endocrinological Diseases, Verona, Italy
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Pediatric Section, Department Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
Regional Center for the Diagnosis and Treatment of Children and Adolescents Rare Skeletal Disorders, Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy
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.1177/0009922817729484 ) 11 Evans C Gregory JW Barton J Bidder C Gibbs J Pryce R Al-Muzaffar I Ludgate M Warner J John R Transient congenital hypothyroidism due to thyroid-stimulating hormone receptor blocking antibodies: a case series . Annals of
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
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associated with a hypocoagulant state and a higher risk of bleeding episodes ( 1 , 2 , 3 , 4 ). Concerning hypothyroidism and the impact of low levels of thyroid hormones, original investigations have mainly described prolonged activated partial
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Introduction Central hypothyroidism (CeH) is a heterogeneous disorder characterised by reduced thyroid hormone (TH) secretion due to pituitary and/or hypothalamic disorders. There is insufficient stimulation of TH secretion from an otherwise
Department of Pediatric Endocrinology, Faculty of Medicine, Istinye University, Istanbul, Turkey
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Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
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Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
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). Primary CH with GIS (GIS-CH) is caused by dyshormonogenesis, defects of hormone synthesis within normally located, sometimes goitrous thyroid gland. It is usually due to autosomal recessive mutations in TG, TPO, DUOX2, DUOXA2, SLC26A4 (Pendrin), SLC5A5
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Data and Data Support, Region Zealand, Sorø, Denmark
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Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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apoptosis ( 11 ). Regarding thyroid function, the impact of oxidative stress is of particular interest, since thyroid hormones are crucial for oxidative metabolism and energy expenditure ( 12 ). There are numerous ways of measuring oxidative stress. The
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://dx.doi.org/10.1016/s0168-8227(03)00066-4 . 10 Liu YY , Brent GA . Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation . Trends Endocrinol Metab . 2010 ; 21 ( 3 ): 166 – 73 . http://dx.doi.org/10.1016/j.tem.2009
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emerged in parallel with the thyroid hormones rising to supranormal levels (Fig. 1 ). Therefore, the treatment was withdrawn. Fig. 1. The response to LT4 replacement therapy in the patient with macro-TSH. Initially, plasma TSH was high but