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Department of Pediatrics, Turku University Hospital, Turku, Finland
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Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Department of Medicine, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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mutations lead to hot thyroid nodules (HTN). Somatic point mutations that constitutively activate the TSHR were first identified in HTN ( 1 ). Subsequently, TSHR germline mutations were identified ( 2 ). Somatic and germline TSHR mutations show similar gene
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, ranging from 5 mm to 14 mm. Synchronous thyroid nodules were discovered, and a 4.1 × 2.8 cm thyroid nodule biopsy was positive for follicular variant PTC. He is in otherwise good health. He has not been exposed to radiation or chemotherapy, nor does his
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needle aspirates can be used to infer the risk of malignancy in indeterminate thyroid nodules ( 6 , 7 , 8 ) and for genetic analysis in other types of cancers such as pancreatic cancers ( 9 ). For thyroid cancer patients, when FFPE tumoral tissue is
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Medullary thyroid carcinoma (MTC) is a rare but aggressive thyroid tumor, with 25% of hereditary and 75% of sporadic forms. RET mutations are found in 98% of hereditary MTC and in 55% of sporadic MTC ( 1 ). The most frequent somatic RET
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer . Thyroid 2016 26 1 – 133 . ( https://doi.org/10.1089/thy.2015.0020 ) 26 Yim JH Kim
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Bible KC Doherty GM Mandel SJ Nikiforov YE Pacini F Randolph GW Sawka AM Schlumberger M , 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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subsets, a 5 mm slice thickness, and a 168 × 168 matrix, using the TrueX algorithm based on the point-spread function. PET/CT data analysis The [ 18 F]F-DOPA PET/CT examinations were evaluated by two experts in this field. Thyroid nodules, lymph