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Andrea Leoncini
Andrea Leoncini
Clinic for Radiology, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
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Chiara Camponovo
Chiara Camponovo
Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
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Gaetano Paone
Gaetano Paone
Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Elena Gamarra
Elena Gamarra
Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
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Giorgio Treglia
Giorgio Treglia
Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Pierpaolo Trimboli
Pierpaolo Trimboli
Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
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Introduction Thyroid nodule (TN) is a common pathological condition requiring a specific diagnostic workup ( 1 ). The first step in diagnosing thyroid disorders is to conduct a physical examination of the thyroid gland, followed by laboratory
Jiahui Wu
Jiahui Wu
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Xunyang Hu
Xunyang Hu
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Paula Seal
Paula Seal
EFW Radiology, Calgary, Alberta, Canada
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Parthiv Amin
Parthiv Amin
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Brendan Diederichs
Brendan Diederichs
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Mayfair Radiology, Calgary, Alberta, Canada
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Mayfair Radiology, Calgary, Alberta, Canada
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Ralf Paschke
Ralf Paschke
Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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nodes and the retrospective identification of suspicious ultrasound features and the prognostic importance of size stability vs growth for small thyroid bed nodules ( 2 , 3 ). The retrospective review of neck ultrasounds for 90 intermediate recurrence
Adile Begüm Bahçecioğlu
Adile Begüm Bahçecioğlu
Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey
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Alptekin Gürsoy
Alptekin Gürsoy
Department of Endocrinology and Metabolism, Ankara Guven Hospital, Ankara, Turkey
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Serpil Dizbay Sak
Serpil Dizbay Sak
Department of Pathology, Ankara University, School of Medicine Ankara, Turkey
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Seyfettin Ilgan
Seyfettin Ilgan
Department of Nuclear Medicine, Ankara Guven Hospital, Ankara, Turkey
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Banu Bilezikçi
Banu Bilezikçi
Department of Pathology, Ankara Guven Hospital, Ankara, Turkey
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Murat Faik Erdoğan
Murat Faik Erdoğan
Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey
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the nodule or thyroid tissue. This phenomenon, which represents connective tissue, is observed in more than 90% of cases and can also occur in normal thyroid tissue. Its occurrence is influenced by the angle between the ultrasound wave and the
Inês Cosme
Inês Cosme
Department of Endocrinology, Unidade Local de Saúde Santa Maria, Lisbon, Portugal
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Ana Figueiredo
Ana Figueiredo
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Sara Pinheiro
Sara Pinheiro
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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diseases, thyroid dysfunction, routine check-up, symptoms not related to thyroid nodules, and TC diagnosed incidentally at the histological examination of benign thyroid lesions. In the non-incidental group, we included patients with palpable or visible
Luigino Dal Maso
Luigino Dal Maso
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Daniela Pierannunzio
Daniela Pierannunzio
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Silvia Francisci
Silvia Francisci
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Angela De Paoli
Angela De Paoli
Epidemiological Department, Azienda Zero, Padova, Italy
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Federica Toffolutti
Federica Toffolutti
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Salvatore Vaccarella
Salvatore Vaccarella
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France
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Silvia Franceschi
Silvia Franceschi
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Ugo Fedeli
Ugo Fedeli
Epidemiological Department, Azienda Zero, Padova, Italy
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of the DEPTH Working Group
of the DEPTH Working Group
of the DEPTH Working Group
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diagnostic pressure, namely fine-needle aspiration biopsies of thyroid nodules, were reported at the population level in some Italian areas after 2014 ( 24 ). Meanwhile, the growth in thyroid cancer surgery previously registered in Italy leveled off after
Maria Mavromati
Maria Mavromati
Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Verdiana Caironi
Verdiana Caironi
Department of Internal Medicine, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Via Tesserete Lugano, Switzerland
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Essia Saiji
Essia Saiji
Department of Pathology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Maria-Isabel Vargas
Maria-Isabel Vargas
Department of Neuroradiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Shahan Momjian
Shahan Momjian
Department of Neurosurgery, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Stephanie Andrade-Lopes
Stephanie Andrade-Lopes
Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
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Capucine Gubert
Capucine Gubert
Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
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Marco Stefano Demarchi
Marco Stefano Demarchi
Department of Thoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
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Ismini Mainta
Ismini Mainta
Department of Nuclear Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
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François R Jornayvaz
François R Jornayvaz
Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Kaveh Samii
Kaveh Samii
Department of Hematology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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Grégoire Stalder
Grégoire Stalder
Service and Central Laboratory of Hematology, Lausanne University Hospital, rue du Bugnon Lausanne, Switzerland.
Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland
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Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland
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Sophie Leboulleux
Sophie Leboulleux
Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland
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patient with a single hypothalamic mass and no extra-cranial lesions, who was diagnosed with LCH on thyroid cytology despite nonspecific thyroid imaging and the absence of thyroid nodules. Case description A 25-year-old female patient was referred
Lan Wu
Lan Wu
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Salvatore Vaccarella
Salvatore Vaccarella
International Agency for Research on Cancer (IARC/WHO), Lyon, France
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Chen-Yang Feng
Chen-Yang Feng
Information Technology Center, Sun Yat-sen University Cancer Center, Guangzhou, China
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Luigino Dal Maso
Luigino Dal Maso
Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
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Yu Chen
Yu Chen
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Wei-Wei Liu
Wei-Wei Liu
Department of Head and Neck, Sun Yat-sen University Cancer Center, Guangzhou, China
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Miao-Bian Liang
Miao-Bian Liang
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Zike Zhang
Zike Zhang
Department of Laboratory Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
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Jun Yang
Jun Yang
School of Public Health, Guangzhou Medical University, Guangzhou, China
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Su-Mei Cao
Su-Mei Cao
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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Mengmeng Li
Mengmeng Li
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
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: zealous imaging has increased detection and treatment of low risk tumours . BMJ 2013 347 f4706 . ( https://doi.org/10.1136/bmj.f4706 ) 6 Chooi JE Ravindiran A & Balasubramanian SP . The influence of incidental detection of thyroid nodule on
Daniela Cavaco
Daniela Cavaco
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Ana Filipa Martins
Ana Filipa Martins
Department of Endocrinology and Diabetes, Hospital da Luz, Lisbon, Portugal
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Rafael Cabrera
Rafael Cabrera
Department of Patology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Helena Vilar
Helena Vilar
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal
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Nova Medical School, Lisbon, Portugal
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and six had positive anti-thyroid peroxidase, but only three patients (9.1%) were hypothyroid before surgery. In 28 patients (84.8%), cervical complaints (goiter/thyroid nodule or adenopathy) led to the diagnosis, and in the remaining patients, the
Junyu Tong
Junyu Tong
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Maomei Ruan
Maomei Ruan
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China
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Yuchen Jin
Yuchen Jin
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Hao Fu
Hao Fu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Lin Cheng
Lin Cheng
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Qiong Luo
Qiong Luo
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Zhiyan Liu
Zhiyan Liu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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Zhongwei Lv
Zhongwei Lv
Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Libo Chen
Libo Chen
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
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evidence-based review of poorly differentiated thyroid cancer . World Journal of Surgery 2007 31 934 – 945 . ( https://doi.org/10.1007/s00268-007-9033-3 ) 63 American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated
Daniela Dias
Daniela Dias
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Inês Damásio
Inês Damásio
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Pedro Marques
Pedro Marques
Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisbon, Portugal
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Helder Simões
Helder Simões
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Ricardo Rodrigues
Ricardo Rodrigues
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Branca Maria Cavaco
Branca Maria Cavaco
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal
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Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal
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://doi.org/10.1056/NEJMoa2005651 ) 14 Haugen BR Alexander EK Bible KC Doherty GM Mandel SJ Nikiforov YE Pacini F Randolph GW Sawka AM Schlumberger M , 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and
