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  • Thyroid cancer - clinical x
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Jiahui Wu Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Xunyang Hu Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Paula Seal EFW Radiology, Calgary, Alberta, Canada
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Parthiv Amin Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Brendan Diederichs Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Mayfair Radiology, Calgary, Alberta, Canada

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Ralf Paschke Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Introduction Current postoperative follow-up (FU) and dynamic response to treatment (RTT) assessment of thyroid cancer primarily depends on postoperative neck ultrasound (POU) and thyroglobulin (Tg) determination ( 1 ). This FU strategy is

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Andrea Leoncini Clinic for Radiology, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland

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Chiara Camponovo Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland

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Gaetano Paone Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland

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Elena Gamarra Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland

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Giorgio Treglia Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland
Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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Pierpaolo Trimboli Thyroid Unit, Clinic for Endocrinology and Diabetology, Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland
Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland

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tests and a neck ultrasound, if necessary. Thyroid function tests, such as TSH measurement, are used to assess thyroid function, while ultrasound can help to determine the risk of malignancy of any detected lesions. This diagnostic process is highly

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Francesca Orsolini Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Pierpaolo Falcetta Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Domenico Canale Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Fulvio Basolo Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy

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Greta Alì Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy

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Francesca Manassero Division of Urology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy

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, we report the unusual case of a patient with MEN2A syndrome with bilateral testicular metastases from metastatic and advanced MTC, incidentally discovered at ultrasound (US) imaging and histologically confirmed. Case presentation The case was

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Santiago Tofé Department of Endocrinology, University Hospital Son Espases, Palma de Mallorca, Spain

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Iñaki Argüelles Department of Endocrinology, University Hospital Son Espases, Palma de Mallorca, Spain

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Ana Forteza Department of Pathology, University Hospital Son Espases, Palma de Mallorca, Spain

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Cristina Álvarez Department of Surgery, Section of Endocrine Surgery, University Hospital Son Espases, Palma de Mallorca, Spain

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Alessandra Repetto Department of Nuclear Medicine, University Hospital Son Espases, Palma de Mallorca, Spain

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Luis Masmiquel Department of Endocrinology, University Hospital Son Llatzer, Palma de Mallorca, Spain

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Irene Rodríguez Department of Endocrinology, University Hospital Son Llatzer, Palma de Mallorca, Spain

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Eladio Losada Department of Endocrinology, Hospital Can Misses, Ibiza, Spain

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Nuria Sukunza Department of Endocrinology, Hospital de Manacor, Manacor, Spain

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María Cabrer Department of Endocrinology, Hospital Comarcal de Inca, Inca, Spain

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Mildred Sifontes Department of Pathology, Hospital Mateu Orfila, Menorca, Spain

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María del Mar del Barrio Department of Pathology, Hospital Mateu Orfila, Menorca, Spain

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Antonia Barceló Department of Laboratory, University Hospital Son Espases, Palma de Mallorca, Spain

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Álvaro Tofé Department of Maxillofacial Surgery, Hospital Puerta del Mar, Cádiz, Spain

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Vicente Pereg Department of Endocrinology, University Hospital Son Espases, Palma de Mallorca, Spain

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-specific MRs in this large cohort of patients with TC. Finally, we have performed an additional analysis to explore the role of changes in the routine management of thyroid nodular disease, that is, performance of neck ultrasound (US) and fine-needle aspiration

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Adile Begüm Bahçecioğlu Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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Alptekin Gürsoy Department of Endocrinology and Metabolism, Ankara Guven Hospital, Ankara, Turkey

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Serpil Dizbay Sak Department of Pathology, Ankara University, School of Medicine Ankara, Turkey

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Seyfettin Ilgan Department of Nuclear Medicine, Ankara Guven Hospital, Ankara, Turkey

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Banu Bilezikçi Department of Pathology, Ankara Guven Hospital, Ankara, Turkey

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Murat Faik Erdoğan Department of Endocrinology and Metabolism, Ankara University, School of Medicine, Ankara, Turkey

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the nodule or thyroid tissue. This phenomenon, which represents connective tissue, is observed in more than 90% of cases and can also occur in normal thyroid tissue. Its occurrence is influenced by the angle between the ultrasound wave and the

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Maria Mavromati Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Verdiana Caironi Department of Internal Medicine, Lugano Regional Hospital, Ente Ospedaliero Cantonale, Via Tesserete Lugano, Switzerland

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Essia Saiji Department of Pathology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Maria-Isabel Vargas Department of Neuroradiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Shahan Momjian Department of Neurosurgery, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Stephanie Andrade-Lopes Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Capucine Gubert Department of Internal Medicine, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Marco Stefano Demarchi Department of Thoracic and Endocrine Surgery, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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Ismini Mainta Department of Nuclear Medicine, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland

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François R Jornayvaz Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Kaveh Samii Department of Hematology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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Grégoire Stalder Service and Central Laboratory of Hematology, Lausanne University Hospital, rue du Bugnon Lausanne, Switzerland.
Service of Hematology and Laboratory of Hematology, Institut Central des Hôpitaux, Hôpital du Valais, Av. du Grand-Champsec, Sion, Switzerland

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Sophie Leboulleux Department of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil, Geneva, Switzerland
University of Geneva, Faculty of Medicine, Rue Michel Servet, Geneva, Switzerland

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, 3 , 4 , 5 , 6 , 7 ). Thyroid ultrasound-guided fine needle aspiration cytology (FNAC) can be a noninvasive and useful tool to confirm the diagnosis and prevent unnecessary transcranial biopsy ( 3 , 8 ). Here we present the case of a young

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Shaodong Hou Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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Yiceng Sun Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Zeyu Yang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Mi Tang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Tingjie Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cong Shao Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cunye Yan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Linlong Mo Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Yuquan Yuan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Supeng Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Fan Zhang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer . European Thyroid Journal 2013 2 147 – 159 . ( https://doi.org/10.1159/000354537 ) 4 Solorzano CC Carneiro DM Ramirez M Lee

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Furio Pacini Section of Endocrinology, University of Siena, Siena, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Rossella Elisei Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Martin Schlumberger Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Johannes W Smit Radboud University Medical Center, Nijmegen, Netherlands

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- and outside of Europe ( 1 , 2 ). This increase is largely attributable to a better detection of small papillary thyroid carcinomas (PTC), as a result of screening bias (non-selective use of neck ultrasound and fine needle aspiration cytology) ( 3

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Hideyuki Imai Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Natsuko Watanabe Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Rei Hirose Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Masakazu Koshibu Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Masahiro Ichikawa Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Akiko Sankoda Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Shigenori Hiruma Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Nami Suzuki Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Masako Matsumoto Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Miho Fukushita Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Ai Yoshihara Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Jaeduk Yoshimura Noh Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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patients (71%), while two patients (29%) were euthyroid. The median CRP was 2.22 (range: 0.42–5.79) mg/dL, and all patients had high CRP levels. All patients had a hypoechoic lesion of the thyroid gland confirmed by ultrasound. The hypoechoic areas were

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Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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prophylactic lymph node dissection, central compartment (CCND) and/or laterocervical compartment (LCND) lymph node dissection were performed if lymph node metastases were identified before surgery at neck ultrasound (US) and confirmed through fine needle

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