hypothyroidism with high TSH (>200 mU/l) and low FT 4 serum levels (0.2 ng/dl, normal range for age 1.78-4.2 ng/dl) [ 11 ]. Thyroid 99 Tc scintigraphy and US scan revealed a lingual thyroid ectopy, therefore L- T 4 replacement therapy was introduced on the 9
Tiziana de Filippis, Federica Marelli, Maria Cristina Vigone, Marianna Di Frenna, Giovanna Weber, and Luca Persani
Robert Opitz, Francesco Antonica, and Sabine Costagliola
might manifest as either athyreosis, thyroid ectopy, hypoplasia or hemiagenesis [ 3 , 4 ]. All these phenotypes are considered to result from defects in embryonic thyroid development. The molecular mechanisms underlying TD in human newborns, however
