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of the bile duct [ 10 ]. Biliary diseases in humans can be associated with altered claudin-1 expression or mutations. For instance, in the neonatal ichthyosis-sclerosing cholangitis syndrome, claudin-1 gene mutations may lead to increased paracellular
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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role in inducing their proliferation in response to cholestasis [ 19 ], drugs inhibiting VEGF-R are predicted to cause biliary diseases. The antiangiogenic activity of TKIs at the epithelium and muscularis layers of the gallbladder may also contribute