Laura Fugazzola
Laura Fugazzola
Department of Clinical Sciences and Community Health, University of Milan and Endocrine Unit, Fondazione IRCCS Ca' Granda, Milan, Italy
Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
Search for other papers by Laura Fugazzola in
Google Scholar
PubMed
Calcitonin, the Marker of Medullary Thyroid Cancer Medullary thyroid cancer (MTC) can be a very aggressive tumor. Significant differences in survival have been reported according to the stage of the tumor at the time of diagnosis, the survival
Fabio Maino
Fabio Maino
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Fabio Maino in
Google Scholar
PubMed
Search for other papers by Fabio Maino in
Google Scholar
PubMed
Cristina Dalmiglio
Cristina Dalmiglio
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Cristina Dalmiglio in
Google Scholar
PubMed
Search for other papers by Cristina Dalmiglio in
Google Scholar
PubMed
Nicoletta Benenati
Nicoletta Benenati
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Nicoletta Benenati in
Google Scholar
PubMed
Search for other papers by Nicoletta Benenati in
Google Scholar
PubMed
Michele Campanile
Michele Campanile
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Michele Campanile in
Google Scholar
PubMed
Search for other papers by Michele Campanile in
Google Scholar
PubMed
Tania Pilli
Tania Pilli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Tania Pilli in
Google Scholar
PubMed
Search for other papers by Tania Pilli in
Google Scholar
PubMed
Raffaella Forleo
Raffaella Forleo
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Raffaella Forleo in
Google Scholar
PubMed
Search for other papers by Raffaella Forleo in
Google Scholar
PubMed
Lucia Brilli
Lucia Brilli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Lucia Brilli in
Google Scholar
PubMed
Search for other papers by Lucia Brilli in
Google Scholar
PubMed
Cristina Ciuoli
Cristina Ciuoli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Cristina Ciuoli in
Google Scholar
PubMed
Search for other papers by Cristina Ciuoli in
Google Scholar
PubMed
Silvia Cantara
Silvia Cantara
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Silvia Cantara in
Google Scholar
PubMed
Search for other papers by Silvia Cantara in
Google Scholar
PubMed
Marco Capezzone
Marco Capezzone
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Marco Capezzone in
Google Scholar
PubMed
Search for other papers by Marco Capezzone in
Google Scholar
PubMed
Alessandra Cartocci
Alessandra Cartocci
Department of Medical Biotechnologies, University of Siena, Siena, Italy
Search for other papers by Alessandra Cartocci in
Google Scholar
PubMed
Search for other papers by Alessandra Cartocci in
Google Scholar
PubMed
Furio Pacini
Furio Pacini
Humanitas Clinical Institute, Humanitas University, Rozzano, Italy
Search for other papers by Furio Pacini in
Google Scholar
PubMed
Search for other papers by Furio Pacini in
Google Scholar
PubMed
Maria Grazia Castagna
Maria Grazia Castagna
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
Search for other papers by Maria Grazia Castagna in
Google Scholar
PubMed
Search for other papers by Maria Grazia Castagna in
Google Scholar
PubMed
Introduction Calcitonin (CT), a 32-amino acid calcium-lowering peptide secreted by the C-cells (parafollicular cells) of the thyroid, is used as a marker for the diagnosis and the follow-up of medullary thyroid cancer (MTC) [ 1 ]. In patients
Else Marie Opsahl
Else Marie Opsahl
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Search for other papers by Else Marie Opsahl in
Google Scholar
PubMed
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Search for other papers by Else Marie Opsahl in
Google Scholar
PubMed
Lars Andreas Akslen
Lars Andreas Akslen
Section for Pathology, Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
Search for other papers by Lars Andreas Akslen in
Google Scholar
PubMed
Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
Search for other papers by Lars Andreas Akslen in
Google Scholar
PubMed
Ellen Schlichting
Ellen Schlichting
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
Search for other papers by Ellen Schlichting in
Google Scholar
PubMed
Search for other papers by Ellen Schlichting in
Google Scholar
PubMed
Turid Aas
Turid Aas
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
Search for other papers by Turid Aas in
Google Scholar
PubMed
Search for other papers by Turid Aas in
Google Scholar
PubMed
Katrin Brauckhoff
Katrin Brauckhoff
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
Search for other papers by Katrin Brauckhoff in
Google Scholar
PubMed
Search for other papers by Katrin Brauckhoff in
Google Scholar
PubMed
Anne Irene Hagen
Anne Irene Hagen
Department of Breast- and Endocrine Surgery, St. Olavs University Hospital, Trondheim, Norway
Search for other papers by Anne Irene Hagen in
Google Scholar
PubMed
Search for other papers by Anne Irene Hagen in
Google Scholar
PubMed
Alf Frimann Rosenlund
Alf Frimann Rosenlund
Section of Breast- and Endocrine Surgery, Department of Surgery, University Hospital of North Norway, Tromsø, Norway
Search for other papers by Alf Frimann Rosenlund in
Google Scholar
PubMed
Search for other papers by Alf Frimann Rosenlund in
Google Scholar
PubMed
Eva Sigstad
Eva Sigstad
Department of Pathology, Oslo University Hospital, Oslo, Norway
Search for other papers by Eva Sigstad in
Google Scholar
PubMed
Search for other papers by Eva Sigstad in
Google Scholar
PubMed
Krystyna K. Grøholt
Krystyna K. Grøholt
Department of Pathology, Oslo University Hospital, Oslo, Norway
Search for other papers by Krystyna K. Grøholt in
Google Scholar
PubMed
Search for other papers by Krystyna K. Grøholt in
Google Scholar
PubMed
Lars H. Jørgensen
Lars H. Jørgensen
Department of Thoracic Surgery, Oslo University Hospital, Oslo, Norway
Search for other papers by Lars H. Jørgensen in
Google Scholar
PubMed
Search for other papers by Lars H. Jørgensen in
Google Scholar
PubMed
Trine Bjøro
Trine Bjøro
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
Search for other papers by Trine Bjøro in
Google Scholar
PubMed
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
Search for other papers by Trine Bjøro in
Google Scholar
PubMed
disease in the lateral neck [ 3 , 14 ]. High-resolution ultrasound is important in disease staging, enabling the detection of even very small metastatic lymph nodes but not micrometastases. Calcitonin is a good tumor marker in MTC. As a rule, it is
Cléber P. Camacho
Cléber P. Camacho
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Search for other papers by Cléber P. Camacho in
Google Scholar
PubMed
Search for other papers by Cléber P. Camacho in
Google Scholar
PubMed
Susan C. Lindsey
Susan C. Lindsey
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Search for other papers by Susan C. Lindsey in
Google Scholar
PubMed
Search for other papers by Susan C. Lindsey in
Google Scholar
PubMed
Teresa S. Kasamatsu
Teresa S. Kasamatsu
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Search for other papers by Teresa S. Kasamatsu in
Google Scholar
PubMed
Search for other papers by Teresa S. Kasamatsu in
Google Scholar
PubMed
Alberto L. Machado
Alberto L. Machado
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Alberto L. Machado in
Google Scholar
PubMed
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Alberto L. Machado in
Google Scholar
PubMed
João Roberto M. Martins
João Roberto M. Martins
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Search for other papers by João Roberto M. Martins in
Google Scholar
PubMed
Search for other papers by João Roberto M. Martins in
Google Scholar
PubMed
Rosa Paula M. Biscolla
Rosa Paula M. Biscolla
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Rosa Paula M. Biscolla in
Google Scholar
PubMed
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Rosa Paula M. Biscolla in
Google Scholar
PubMed
Magnus R. Dias da Silva
Magnus R. Dias da Silva
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Search for other papers by Magnus R. Dias da Silva in
Google Scholar
PubMed
Search for other papers by Magnus R. Dias da Silva in
Google Scholar
PubMed
José Gilberto H. Vieira
José Gilberto H. Vieira
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by José Gilberto H. Vieira in
Google Scholar
PubMed
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by José Gilberto H. Vieira in
Google Scholar
PubMed
Rui M.B. Maciel
Rui M.B. Maciel
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Rui M.B. Maciel in
Google Scholar
PubMed
Fleury Medicine and Health, São Paulo, Brazil
Search for other papers by Rui M.B. Maciel in
Google Scholar
PubMed
Introduction Serum calcitonin (sCT) is a useful biomarker for medullary thyroid cancer (MTC) and is employed for its diagnosis and follow-up monitoring [ 1 ]. In addition, some guidelines advocate sCT measurements for the differential
Renata Alencar
Renata Alencar
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Renata Alencar in
Google Scholar
PubMed
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Renata Alencar in
Google Scholar
PubMed
Daniel Barretto Kendler
Daniel Barretto Kendler
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Daniel Barretto Kendler in
Google Scholar
PubMed
Search for other papers by Daniel Barretto Kendler in
Google Scholar
PubMed
Fernanda Andrade
Fernanda Andrade
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Search for other papers by Fernanda Andrade in
Google Scholar
PubMed
Search for other papers by Fernanda Andrade in
Google Scholar
PubMed
Carla Nava
Carla Nava
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Search for other papers by Carla Nava in
Google Scholar
PubMed
Search for other papers by Carla Nava in
Google Scholar
PubMed
Daniel Bulzico
Daniel Bulzico
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Search for other papers by Daniel Bulzico in
Google Scholar
PubMed
Search for other papers by Daniel Bulzico in
Google Scholar
PubMed
Cencita Cordeiro de Noronha Pessoa
Cencita Cordeiro de Noronha Pessoa
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Search for other papers by Cencita Cordeiro de Noronha Pessoa in
Google Scholar
PubMed
Search for other papers by Cencita Cordeiro de Noronha Pessoa in
Google Scholar
PubMed
Rossana Corbo
Rossana Corbo
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Rossana Corbo in
Google Scholar
PubMed
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Rossana Corbo in
Google Scholar
PubMed
Fernanda Vaisman
Fernanda Vaisman
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Fernanda Vaisman in
Google Scholar
PubMed
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
Search for other papers by Fernanda Vaisman in
Google Scholar
PubMed
monitored after for serum levels of calcitonin and carcinoembryonic antigen (CEA) usually twice or three times a year. After 2015, CA19-9 serum levels were also routinely measured in these patients and were collected usually at each semester. Imaging tests
Isabelle Clinckspoor
Isabelle Clinckspoor
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Search for other papers by Isabelle Clinckspoor in
Google Scholar
PubMed
Search for other papers by Isabelle Clinckspoor in
Google Scholar
PubMed
Anne-Catherine Gérard
Anne-Catherine Gérard
Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain
Search for other papers by Anne-Catherine Gérard in
Google Scholar
PubMed
Search for other papers by Anne-Catherine Gérard in
Google Scholar
PubMed
Jacqueline Van Sande
Jacqueline Van Sande
IRIBHM, Université Libre de Bruxelles, Brussels
Search for other papers by Jacqueline Van Sande in
Google Scholar
PubMed
Search for other papers by Jacqueline Van Sande in
Google Scholar
PubMed
Marie-Christine Many
Marie-Christine Many
Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain
Search for other papers by Marie-Christine Many in
Google Scholar
PubMed
Search for other papers by Marie-Christine Many in
Google Scholar
PubMed
Lieve Verlinden
Lieve Verlinden
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Search for other papers by Lieve Verlinden in
Google Scholar
PubMed
Search for other papers by Lieve Verlinden in
Google Scholar
PubMed
Roger Bouillon
Roger Bouillon
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Search for other papers by Roger Bouillon in
Google Scholar
PubMed
Search for other papers by Roger Bouillon in
Google Scholar
PubMed
Geert Carmeliet
Geert Carmeliet
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Search for other papers by Geert Carmeliet in
Google Scholar
PubMed
Search for other papers by Geert Carmeliet in
Google Scholar
PubMed
Chantal Mathieu
Chantal Mathieu
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
Search for other papers by Chantal Mathieu in
Google Scholar
PubMed
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
Search for other papers by Chantal Mathieu in
Google Scholar
PubMed
Annemieke Verstuyf
Annemieke Verstuyf
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Search for other papers by Annemieke Verstuyf in
Google Scholar
PubMed
Search for other papers by Annemieke Verstuyf in
Google Scholar
PubMed
Brigitte Decallonne
Brigitte Decallonne
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
Search for other papers by Brigitte Decallonne in
Google Scholar
PubMed
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
Search for other papers by Brigitte Decallonne in
Google Scholar
PubMed
antithyroid antibodies and abnormal thyroid function in humans [ 19 , 20 ], and to modulate autoimmune hyperthyroidism in mice [ 21 ]. Apart from inhibiting osteoclast-mediated bone resorption and increasing renal calcium and phosphate excretion, calcitonin
Simona Censi
Simona Censi
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Simona Censi in
Google Scholar
PubMed
Search for other papers by Simona Censi in
Google Scholar
PubMed
Elisabetta Cavedon
Elisabetta Cavedon
Familial Tumor Unit, Veneto Institute of Oncology, (IOV)-IRCCS, Padua, Italy
Search for other papers by Elisabetta Cavedon in
Google Scholar
PubMed
Search for other papers by Elisabetta Cavedon in
Google Scholar
PubMed
Sara Watutantrige-Fernando
Sara Watutantrige-Fernando
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Sara Watutantrige-Fernando in
Google Scholar
PubMed
Search for other papers by Sara Watutantrige-Fernando in
Google Scholar
PubMed
Susi Barollo
Susi Barollo
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Susi Barollo in
Google Scholar
PubMed
Search for other papers by Susi Barollo in
Google Scholar
PubMed
Loris Bertazza
Loris Bertazza
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Loris Bertazza in
Google Scholar
PubMed
Search for other papers by Loris Bertazza in
Google Scholar
PubMed
Jacopo Manso
Jacopo Manso
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Jacopo Manso in
Google Scholar
PubMed
Search for other papers by Jacopo Manso in
Google Scholar
PubMed
Maurizio Iacobone
Maurizio Iacobone
Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
Search for other papers by Maurizio Iacobone in
Google Scholar
PubMed
Search for other papers by Maurizio Iacobone in
Google Scholar
PubMed
Davide Nacamulli
Davide Nacamulli
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Davide Nacamulli in
Google Scholar
PubMed
Search for other papers by Davide Nacamulli in
Google Scholar
PubMed
Francesca Galuppini
Francesca Galuppini
Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Francesca Galuppini in
Google Scholar
PubMed
Search for other papers by Francesca Galuppini in
Google Scholar
PubMed
Gianmaria Pennelli
Gianmaria Pennelli
Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Gianmaria Pennelli in
Google Scholar
PubMed
Search for other papers by Gianmaria Pennelli in
Google Scholar
PubMed
Caterina Mian
Caterina Mian
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
Search for other papers by Caterina Mian in
Google Scholar
PubMed
Search for other papers by Caterina Mian in
Google Scholar
PubMed
What Is Known about This Topic? The most important clinical prognostic factors for medullary thyroid carcinoma are basal serum calcitonin (Ctn) at diagnosis and pathological stage. When the diameter of the primary cancer exceeds 2
R. Elisei
R. Elisei
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Search for other papers by R. Elisei in
Google Scholar
PubMed
Search for other papers by R. Elisei in
Google Scholar
PubMed
M. Alevizaki
M. Alevizaki
Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Athens, Greece
Search for other papers by M. Alevizaki in
Google Scholar
PubMed
Search for other papers by M. Alevizaki in
Google Scholar
PubMed
B. Conte-Devolx
B. Conte-Devolx
Department of Endocrinology, La Timone Hospital, Aix Marseille University, Marseille, France
Search for other papers by B. Conte-Devolx in
Google Scholar
PubMed
Search for other papers by B. Conte-Devolx in
Google Scholar
PubMed
K. Frank-Raue
K. Frank-Raue
Endocrine Practice, Molecular Laboratory, Heidelberg, Germany
Search for other papers by K. Frank-Raue in
Google Scholar
PubMed
Search for other papers by K. Frank-Raue in
Google Scholar
PubMed
V. Leite
V. Leite
Department of Endocrinology, Portuguese Institute of Oncology and CEDOC, Faculty of Medical Sciences, Lisbon, Portugal
Search for other papers by V. Leite in
Google Scholar
PubMed
Search for other papers by V. Leite in
Google Scholar
PubMed
G.R. Williams
G.R. Williams
Molecular Endocrinology Group, Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
Search for other papers by G.R. Williams in
Google Scholar
PubMed
Search for other papers by G.R. Williams in
Google Scholar
PubMed
were identified by searching PubMed MEDLINE at PubMed (NLM) using the following search terms: medullary thyroid cancer, RET oncogene, calcitonin, calcium, RET gene carriers, MEN 2, pheochromocytoma, hyperparathyroidism, RET genetic counseling, and
Catarina Silvestre
Catarina Silvestre
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
Search for other papers by Catarina Silvestre in
Google Scholar
PubMed
Search for other papers by Catarina Silvestre in
Google Scholar
PubMed
Joaquim Sampaio Matias
Joaquim Sampaio Matias
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
Search for other papers by Joaquim Sampaio Matias in
Google Scholar
PubMed
Search for other papers by Joaquim Sampaio Matias in
Google Scholar
PubMed
Helena Proença
Helena Proença
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
Search for other papers by Helena Proença in
Google Scholar
PubMed
Search for other papers by Helena Proença in
Google Scholar
PubMed
Maria João Bugalho
Maria João Bugalho
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
Search for other papers by Maria João Bugalho in
Google Scholar
PubMed
Search for other papers by Maria João Bugalho in
Google Scholar
PubMed
Introduction Calcitonin (Ctn) is a 32-amino acid polypeptide secreted by the parafollicular cells of the thyroid, called “C” cells. With a known important role in regulating blood calcium in fish and rodents, the role of Ctn in human calcium
Abbas Al-Kurd
Abbas Al-Kurd
Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by Abbas Al-Kurd in
Google Scholar
PubMed
Search for other papers by Abbas Al-Kurd in
Google Scholar
PubMed
David J. Gross
David J. Gross
Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by David J. Gross in
Google Scholar
PubMed
Search for other papers by David J. Gross in
Google Scholar
PubMed
David Zangen
David Zangen
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by David Zangen in
Google Scholar
PubMed
Search for other papers by David Zangen in
Google Scholar
PubMed
Karine Atlan
Karine Atlan
Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by Karine Atlan in
Google Scholar
PubMed
Search for other papers by Karine Atlan in
Google Scholar
PubMed
Haggi Mazeh
Haggi Mazeh
Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by Haggi Mazeh in
Google Scholar
PubMed
Search for other papers by Haggi Mazeh in
Google Scholar
PubMed
Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Search for other papers by Simona Grozinsky-Glasberg in
Google Scholar
PubMed
Search for other papers by Simona Grozinsky-Glasberg in
Google Scholar
PubMed
should be revised to recommend calcitonin screening and prophylactic thyroidectomy at an earlier age in such patients. Due to the rarity of these patients, cumulative literature on the topic is essential, and, therefore, reports such as the present one
