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described below. They were then started on carbimazole tablets at the recommended dosage and were monitored with serial thyroid function tests at regular intervals. The OGTT was repeated after the patients had achieved a stable state of euthyroidism. A
Centre for Endocrine and Diabetes Sciences, Department of Medicine, Cardiff University School of Medicine, Cardiff, UK
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] and a link with fetal choanal atresia and oesophageal atresia [ 10 ] in carbimazole and methimazole exposed pregnancies. • The optimal treatment of hyperthyroidism in pregnancy is now being actively debated following recent concerns regarding the
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endocrinologists for Graves’ hyperthyroidism (GH). The same applies for cases of postpartum thyrotoxicosis. Pharmacokinetics of ATD ATD which are used today include propylthiouracil (PTU), carbimazole (CMZ) and methimazole (MMI) [ 6 ]. CMZ is a prodrug
London School of Hygiene and Tropical Medicine, London
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pregnant women with hyperthyroidism [ 6 ]. However, carbimazole (CBZ), its active metabolite, methimazole (MMI) and propylthiouracil (PTU) are all thought to be equally effective in controlling hyperthyroidism [ 7 ]. Therefore, the choice of ATD is not
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Diagnostics). She was prescribed carbimazole (20 mg) to be taken orally twice a day. The patient was referred to a rheumatology clinic for further investigation of the myalgia. Detailed musculoskeletal examination revealed widespread and profound muscle
University of Lille, Lille, France
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University of Lille, Lille, France
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Department of Dermatology, Lille University Hospital, Lille, France
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University of Lille, Lille, France
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. Carbimazole 20 mg/day was initiated and nivolumab alone was continued after the third double-agent infusion because of a cutaneous adverse event (skin rash with hypereosinophilia). Six weeks after ICI initiation, TSH increased (15 mU/L) and FT4 was
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the medical or surgical therapy groups (p < 0.01). From Laurberg et al. [16]. Treatment with antithyroid drugs (carbimazole/methimazole or propylthiouracil (PTU)) is acceptable either before pregnancy or during pregnancy. However, the risks
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. Graves' disease was considered, and the patient was commenced on 45 mg/day of carbimazole and 80 mg/day of propranolol. At subsequent follow-up examinations, the patient showed good compliance with carbimazole and was clinically asymptomatic. TSH levels
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK
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Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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) with the aim of normalising thyroid hormone levels and then maintaining the patient in a euthyroid state. The ATD chosen in the UK is usually carbimazole (CBZ) because of the significant risk of liver dysfunction with propylthiouracil. ATD can be
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assessment the patient had been diagnosed with thyrotoxicosis, which had been attributed to a multinodular goiter, and was treated with carbimazole. The patient, euthyroid under treatment, underwent a total abdominal hysterectomy and bilateral salpingo