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Nandhini Lakshmana Perumal Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Jayakumar Selvi Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Kalyani Sridharan Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Jayaprakash Sahoo Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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Sadishkumar Kamalanathan Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

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described below. They were then started on carbimazole tablets at the recommended dosage and were monitored with serial thyroid function tests at regular intervals. The OGTT was repeated after the patients had achieved a stable state of euthyroidism. A

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Peter Taylor Departments of Diabetes and Endocrinology, Royal United Hospital, Bath
Centre for Endocrine and Diabetes Sciences, Department of Medicine, Cardiff University School of Medicine, Cardiff, UK

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Sandip Bhatt Departments of Gastroenterology, Royal United Hospital, Bath

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Ravi Gouni Departments of Diabetes and Endocrinology, Royal United Hospital, Bath

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Jonathan Quinlan Departments of Gastroenterology, Royal United Hospital, Bath

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Tony Robinson Departments of Diabetes and Endocrinology, Royal United Hospital, Bath

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] and a link with fetal choanal atresia and oesophageal atresia [ 10 ] in carbimazole and methimazole exposed pregnancies. • The optimal treatment of hyperthyroidism in pregnancy is now being actively debated following recent concerns regarding the

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Spiros Karras Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece

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Gerasimos E. Krassas Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Thessaloniki, Greece

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endocrinologists for Graves’ hyperthyroidism (GH). The same applies for cases of postpartum thyrotoxicosis. Pharmacokinetics of ATD ATD which are used today include propylthiouracil (PTU), carbimazole (CMZ) and methimazole (MMI) [ 6 ]. CMZ is a prodrug

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Peter N. Taylor Thyroid Research Group, Institute of Experimental and Molecular Medicine, School of Medicine, Cardiff University, Cardiff
London School of Hygiene and Tropical Medicine, London

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Bijay Vaidya Department of Endocrinology, Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter, UK

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pregnant women with hyperthyroidism [ 6 ]. However, carbimazole (CBZ), its active metabolite, methimazole (MMI) and propylthiouracil (PTU) are all thought to be equally effective in controlling hyperthyroidism [ 7 ]. Therefore, the choice of ATD is not

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N. Papanikolaou Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Diagnostics). She was prescribed carbimazole (20 mg) to be taken orally twice a day. The patient was referred to a rheumatology clinic for further investigation of the myalgia. Detailed musculoskeletal examination revealed widespread and profound muscle

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Hippolyte Dupuis Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Emilie Merlen Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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Arnaud Jannin Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Philippe Jamme University of Lille, Lille, France
Department of Dermatology, Lille University Hospital, Lille, France

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Alexandre Fagart Department of Nuclear Medicine, Valenciennes Hospital Center, Valenciennes, France

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Marie-Christine Vantyghem Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France
University of Lille, Lille, France

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Miriam Ladsous Department of Endocrinology, Diabetology and Metabolism, Huriez Hospital, Lille University Hospital, Lille, France

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. Carbimazole 20 mg/day was initiated and nivolumab alone was continued after the third double-agent infusion because of a cutaneous adverse event (skin rash with hypereosinophilia). Six weeks after ICI initiation, TSH increased (15 mU/L) and FT4 was

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John H. Lazarus Centre for Endocrine and Diabetes Sciences, Cardiff University, Cardiff, UK

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the medical or surgical therapy groups (p < 0.01). From Laurberg et al. [16]. Treatment with antithyroid drugs (carbimazole/methimazole or propylthiouracil (PTU)) is acceptable either before pregnancy or during pregnancy. However, the risks

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Mahdi Kamoun Endocrinology and Metabolism Department

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Michèle d'Herbomez Department of Nuclear Medicine, Lille University Hospital, Lille

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Christine Lemaire Department of Endocrinology, Regional Hospital of Béthune, Béthune

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Armelle Fayard Endocrinology and Metabolism Department

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Rachel Desailloud Endocrinology and Metabolism Department, Amiens University Hospital, Amiens, France

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Damien Huglo Department of Nuclear Medicine, Lille University Hospital, Lille

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Jean-Louis Wemeau Endocrinology and Metabolism Department

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. Graves' disease was considered, and the patient was commenced on 45 mg/day of carbimazole and 80 mg/day of propranolol. At subsequent follow-up examinations, the patient showed good compliance with carbimazole and was clinically asymptomatic. TSH levels

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Claire L Wood Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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Niamh Morrison Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Michael Cole Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Newcastle upon Tyne, UK

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Malcolm Donaldson Department of Child Health, University of Glasgow School of Medicine, Glasgow, UK

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David B Dunger Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK

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Ruth Wood Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK

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Simon H S Pearce Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

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Timothy D Cheetham Department of Paediatric Endocrinology, Great North Children’s Hospital, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK

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on behalf of the British Society for Paediatric Endocrinology and Diabetes (BSPED)

) with the aim of normalising thyroid hormone levels and then maintaining the patient in a euthyroid state. The ATD chosen in the UK is usually carbimazole (CBZ) because of the significant risk of liver dysfunction with propylthiouracil. ATD can be

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Elli Anagnostou Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Antonios Polymeris Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Georgios Morphopoulos Departments of Pathology, Alexandra General Hospital, Athens, Greece

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Alexios Travlos Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Vassiliki Sarantopoulou Departments of Endocrinology, Alexandra General Hospital, Athens, Greece

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Irini Papaspyrou Departments of Pathology, Alexandra General Hospital, Athens, Greece

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assessment the patient had been diagnosed with thyrotoxicosis, which had been attributed to a multinodular goiter, and was treated with carbimazole. The patient, euthyroid under treatment, underwent a total abdominal hysterectomy and bilateral salpingo

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