Institute of Public Health, University of Copenhagen
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National Research Centre for the Working Environment, Copenhagen
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Department of Palliative Medicine, Bispebjerg Hospital
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should acknowledge this, by incorporating analyses of QoL into a theoretical and statistical model reflecting this complexity [ 5 ]. In order for such a model to reflect the disease in focus, the theoretical model should incorporate clinical variables and
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Background: Postoperative hypoparathyroidism is a common complication following total thyroidectomy. The aim of this study was to investigate the incidence of both transient and permanent hypoparathyroidism in patients undergoing total thyroidectomy in a tertiary referral centre and, furthermore, to identify early predictive risk factors. Methods: Based on a single-institution retrospective review, we identified 582 patients who underwent total thyroidectomy between January 2010 and March 2015. Information on age, gender, pathological diagnosis, duration of surgery, autotransplantation of parathyroid glands, neck dissection, and experience and position of the surgeon was retrieved from the medical records. Furthermore, serum levels of parathyroid hormone and calcium were registered pre- and postoperatively and after 3 and 12 months. Results: The incidence of transient hypoparathyroidism during the first 24 h and 3 months after surgery was 47.8 and 17.8%, respectively. Furthermore, the incidence of permanent hypoparathyroidism 1 year after surgery was 10.7%. A prolonged duration of surgery was significantly associated with hypoparathyroidism. Moreover, autotransplantation of parathyroid glands was a significant predictor of transient hypoparathyroidism after 24 h and 3 months, but was not associated with permanent hypoparathyroidism. Conclusions: Transient and permanent hypoparathyroidism is common among patients undergoing total thyroidectomy in a tertiary referral centre. A duration of surgery >120 min constitutes an independent risk factor due to the risk of ischaemic damage. Regain of function of devascularized parathyroid glands must be expected to last at least 1 year postoperatively. Furthermore, the recovery of autotransplanted parathyroid glands should not be evaluated within 1–3 months after surgery.
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Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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analyzed using the chi-squared test. The differences in serological lipid metabolism and the orbital MRI parameter (EOM-SIR min ) between the GC-effective and -ineffective groups were evaluated. Other clinical variables – such as age; sex; disease duration
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varying intervals from once every 3–12 months, based on the same parameters. Non-Tg-Related Variables Clinical variables including age at diagnosis, gender, and risk category, as well as pathologic variables (pTNM stage and tumor histology) were
ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Hospital de Braga, Braga, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
ACMP5 – Associação Centro de Medicina P5 (P5), School of Medicine, University of Minho, Braga, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
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Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
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ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal
Clinical Academic Center-Braga (2CA-B), Braga, Portugal
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iodine, 284 without iodine); this population was identical to the original in demographic and clinical variables, except for age, in which women with iodine supplementation are 1 year older on average ( P = 0.009). While folic acid intake would be a
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Cronbach’s α of 0.63 in a study among 104 patients undergoing orbital decompression [ 39 ]. Scores did not correlate with clinical variables. The GO-QLS (GO Quality-of-Life Scale) was developed in the USA [ 19 ]. The original questionnaire contained 105
Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
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Department of Endocrinology and Diabetes, Örebro University Hospital, Örebro, Sweden
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Thyroid Federation International, Kungsbacka, Sweden
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Swedish Thyroid Association, Stockholm, Sweden
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Swedish Thyroid Association, Stockholm, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
The National Task Force in Hyperthyroidism, Swedish National System for Knowledge-Driven Management, Umeå, Sweden
Sweden and Wallenberg Center for Molecular and Translational Medicine, Västra Götaland Region, Göteborg, Sweden
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– 204 . ( https://doi.org/10.1210/jcem-44-1-203 ) 9 Wilson IB & Cleary PD . Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes . JAMA 1995 273 59 – 65 . ( https://doi.org/10.1001/jama.1995
