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Established Facts Maternal TSH receptor-blocking antibodies (TBAbs) are a known cause of transient congenital hypothyroidism. Novel Insights Congenital hypothyroidism due to TBAbs can occur in case of a normal concentration
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Developmental Endocrinology Research Group, Institute of Child Health, University College London, London, UK
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Introduction The newborn screening programme for CH was introduced in the UK in 1981 [ 1 , 2 ] and has virtually abolished cases of untreated congenital hypothyroidism (CH). CH is a common (1 in 3,000-4,000 live births) condition [ 3 , 4 ] in
Pediatric Department B, Ha’Emek Medical Center, Afula, Israel
Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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GGA – Galil Genetic Analysis Laboratory Ltd., Kazerin, Israel
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Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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result in hearing impairment (HI) [ 1 - 3 ]. Deaf-mutism and HI are common in areas of iodine deficiency [ 4 ] and were reported in patients with congenital hypothyroidism (CH) prior to the implementation of thyroid neonatal screening in the 1980s [ 5
Laboratorio 6, Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Delegación Tlalpan, Ciudad de México, México
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stage causes congenital hypothyroidism that alters thyroid and metabolic programming. This idea is supported by the fetal origin of the metabolic diseases hypothesis ( 2 , 3 ). Thus, metabolic diseases have their origin during the early life stages when
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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Introduction Congenital hypothyroidism (CH) is an inborn disorder of the endocrine system with potentially severe health consequences for the affected individual and was the second disorder to be included in the national newborn screening (NBS
Department of Pediatric Endocrinology, Faculty of Medicine, Istinye University, Istanbul, Turkey
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Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
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Department of Medical Genetics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey
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Introduction Primary congenital hypothyroidism (CH) is the most common endocrine disorder in newborns, with an incidence ranging from 1/1000 to 1/3000 worldwide ( 1 ). The incidence of CH has doubled over the last two decades largely due to
Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Department of Computer Science, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
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Amsterdam Public Health, Amsterdam, The Netherlands
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Department of Endocrinology and Metabolism, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Department of Paediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam Gastroenterology, Endocrinology and Metabolism, Amsterdam, The Netherlands
Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Department of Pediatrics, Division of Metabolic Disorders, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit, Boelelaan, Amsterdam, The Netherlands
Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
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Department of Laboratory Medicine, Endocrine Laboratory, Amsterdam UMC location University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Introduction Congenital hypothyroidism (CH), an inborn thyroid hormone (TH) deficiency, can be divided into primary (or thyroidal) CH and central (or secondary) CH. Primary CH is most prevalent and results from an un(der)developed thyroid
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Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
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Introduction Congenital hypothyroidism (CH) is thyroid hormone deficiency at birth mostly caused by impaired development of the thyroid gland or hormone biosynthesis (primary or thyroidal CH, CH-T). A less frequent, but equally important cause
Division of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Division of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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disease), and congenital hypothyroidism (CH) of variable severity, associated either with athyreosis, hypoplasia or an apparently normal gland in situ [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], but not with ectopy as recently indicated also in the document of the CH
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The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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primary congenital hypothyroidism (CH) ( 17 , 18 ). The potential effects of maternal thyroid disease on offspring have led to the clinical practice of recommending serum thyroid function tests (TFT), including free T4 (FT4) and TSH, in infants born to