Laura Agate
Laura Agate
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Francesca Bianchi
Francesca Bianchi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Federica Brozzi
Federica Brozzi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Pierina Santini
Pierina Santini
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Valeria Bottici
Valeria Bottici
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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David Viola
David Viola
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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values and metastatic lesions detected by ptWBS. Three out of 4 cases with distant metastases had a serum Tg value > 10 ng/mL (Fig. 1 ). Fig. 1. Serum Tg values in patients with 131 I uptake outside the thyroid bed detected by ptWBS. No
M. Schlumberger
M. Schlumberger
Department of Nuclear Medicine and Endocrine Oncology, Institute Gustave-Roussy and University Paris Sud, Villejuif, France
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L. Bastholt
L. Bastholt
Department of Oncology, Odense University Hospital, Odense, Denmark
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H. Dralle
H. Dralle
Department of Surgery, Martin Luther University, Halle-Wittenberg Medical Faculty, Halle/Saale, Germany
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B. Jarzab
B. Jarzab
MSC Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
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F. Pacini
F. Pacini
Department of Endocrinologia, University of Siena, Siena, Italy
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J.W.A. Smit
J.W.A. Smit
Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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(MTC) accounts for less than 5% of all thyroid cancers [ 1 , 5 ]. Distant metastases are observed at presentation in 7–23% of MTC patients [ 1 , 5 ] and can be imaged with standardized protocols [ 6 ]. Symptomatic clinical disease will occur in one to
Pedro Weslley Souza Rosario
Pedro Weslley Souza Rosario
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Gabriela Franco Mourão
Gabriela Franco Mourão
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Pedro Henrique Lopes Oliveira
Pedro Henrique Lopes Oliveira
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Tulio Henrique Silva
Tulio Henrique Silva
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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the aggressive subtype, and (iv) absence of lymph node (LN) involvement and extrathyroidal extension (ETE) apparent on ultrasonography (US) and of clinically detectable distant metastases [ 1 - 5 ]. Thus, the safe selection of candidates for AS largely
Daniela Cavaco
Daniela Cavaco
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Ana Filipa Martins
Ana Filipa Martins
Department of Endocrinology and Diabetes, Hospital da Luz, Lisbon, Portugal
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Rafael Cabrera
Rafael Cabrera
Department of Patology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Helena Vilar
Helena Vilar
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal
Nova Medical School, Lisbon, Portugal
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Nova Medical School, Lisbon, Portugal
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and/or stimulated Tg, raising anti-Tg antibodies, or evidence of loco-regional or distant metastases. For each patient, data was recorded regarding age, gender, signs/symptoms at presentation, biochemical parameters, US and cytological findings, type
Markus Eszlinger
Markus Eszlinger
Departments of Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Paul Stewardson
Paul Stewardson
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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John B McIntyre
John B McIntyre
Precision Oncology Hub Laboratory, Alberta Health Services, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Adrian Box
Adrian Box
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Moosa Khalil
Moosa Khalil
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Martin Hyrcza
Martin Hyrcza
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Konstantin Koro
Konstantin Koro
Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Dean Ruether
Dean Ruether
Section of Medical Oncology, Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Jiahui Wu
Jiahui Wu
Department of Medical Science and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Heritage Medical Research Building, Calgary, Alberta, Canada
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). In a Massachusetts General Hospital series of primary thyroid carcinoma, NTRK fusions were found in 3.1% of cases and 6/11 patients with NTRK fusions had distant metastases ( 12 ). In a series of papillary thyroid carcinomas (PTCs), NTRK fusions
Simona Censi
Simona Censi
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Elisabetta Cavedon
Elisabetta Cavedon
Familial Tumor Unit, Veneto Institute of Oncology, (IOV)-IRCCS, Padua, Italy
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Sara Watutantrige-Fernando
Sara Watutantrige-Fernando
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Susi Barollo
Susi Barollo
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Loris Bertazza
Loris Bertazza
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Jacopo Manso
Jacopo Manso
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Maurizio Iacobone
Maurizio Iacobone
Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
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Davide Nacamulli
Davide Nacamulli
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Francesca Galuppini
Francesca Galuppini
Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Gianmaria Pennelli
Gianmaria Pennelli
Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Caterina Mian
Caterina Mian
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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–4 cm, there is always central lymph node involvement. Distant metastases are to be expected when preoperative basal Ctn levels are higher than 500 pg/mL. What Does This Case Report Add? We describe a case of medullary thyroid
Marko Stojanović
Marko Stojanović
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Sandra Pekić
Sandra Pekić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Mirjana Doknić
Mirjana Doknić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Dragana Miljić
Dragana Miljić
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Slavica Ćirić
Slavica Ćirić
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Aleksandar Diklić
Aleksandar Diklić
Faculty of Medicine, University of Belgrade
Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Svetislav Tatić
Svetislav Tatić
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Miloje Joksimović
Miloje Joksimović
Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia
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Emilija Manojlović-Gačić
Emilija Manojlović-Gačić
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Milica Skender-Gazibara
Milica Skender-Gazibara
Faculty of Medicine, University of Belgrade
Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Vera Popović
Vera Popović
Faculty of Medicine, University of Belgrade
Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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report highlights difficulties in diagnosing sellar masses when the primary malignancy is undiagnosed. Not only was the primary malignancy not known but there were no other distant metastases either. Of particular challenge was the management of the
Renata Alencar
Renata Alencar
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Daniel Barretto Kendler
Daniel Barretto Kendler
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Fernanda Andrade
Fernanda Andrade
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Carla Nava
Carla Nava
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Daniel Bulzico
Daniel Bulzico
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Cencita Cordeiro de Noronha Pessoa
Cencita Cordeiro de Noronha Pessoa
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Rossana Corbo
Rossana Corbo
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Fernanda Vaisman
Fernanda Vaisman
Endocrinology Service, Department of Medicine, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Endocrinology Service, Department of Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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diagnosis. Tumor size, the presence of local or distant metastases, and first postoperative calcitonin and CEA also reached the level of statistical significance. Surprisingly, age at diagnosis was not a significant factor associated with death in this group
Francesca Orsolini
Francesca Orsolini
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Alessandro Prete
Alessandro Prete
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Pierpaolo Falcetta
Pierpaolo Falcetta
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Domenico Canale
Domenico Canale
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Fulvio Basolo
Fulvio Basolo
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
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Greta Alì
Greta Alì
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy
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Francesca Manassero
Francesca Manassero
Division of Urology, Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Endocrine Unit, University of Pisa, Pisa, Italy
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). In 30–50% of the cases, MTC is accompanied by metastases in cervical and/or paratracheal lymph nodes, and the tumor spreads also to the upper and anterior mediastinal lymph nodes. Distant metastases are present at the diagnosis in 10–15% of patients
Else Marie Opsahl
Else Marie Opsahl
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Lars Andreas Akslen
Lars Andreas Akslen
Section for Pathology, Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
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Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
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Ellen Schlichting
Ellen Schlichting
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
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Turid Aas
Turid Aas
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
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Katrin Brauckhoff
Katrin Brauckhoff
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
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Anne Irene Hagen
Anne Irene Hagen
Department of Breast- and Endocrine Surgery, St. Olavs University Hospital, Trondheim, Norway
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Alf Frimann Rosenlund
Alf Frimann Rosenlund
Section of Breast- and Endocrine Surgery, Department of Surgery, University Hospital of North Norway, Tromsø, Norway
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Eva Sigstad
Eva Sigstad
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Krystyna K. Grøholt
Krystyna K. Grøholt
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Lars H. Jørgensen
Lars H. Jørgensen
Department of Thoracic Surgery, Oslo University Hospital, Oslo, Norway
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Trine Bjøro
Trine Bjøro
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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patients, respectively. Of all the patients with metastatic lymph nodes in the lateral neck, >50% had preoperative calcitonin >1,000 pmol/L. Furthermore, 50% of the patients with clinical distant metastases had calcitonin level ≤3,000 pmol/L, and of the
