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Genfeng Yu Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Siyang Liu Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Cheng Song Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Qintao Ma Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Xingying Chen Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Yuqi Jiang Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Hualin Duan Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Yajun He Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Dongmei Wang Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Heng Wan Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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Jie Shen Department of Endocrinology and Metabolism, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Guangdong, China

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central sensitivity indices include the thyrotroph thyroxine resistance index (TT4RI) and TSH index (TSHI). The FT3/FT4 ratio reflects deiodinase activity and is a proxy for peripheral thyroid hormone sensitivity ( 21 ). Central resistance phenomena affect

Article Type:
Research Article
Collections:
Metabolic and cardiovascular effects of thyroid hormone
DOI:
https://doi.org/10.1530/ETJ-23-0130
Volume/Issue:
Volume 13: Issue 1
Open access
Stasa Ivkovic Clinical Center of Serbia, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Belgrade, Serbia

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secretion (table 2 ) [ 1 ]. Total cholesterol serum concentration dropped significantly after the introduction of combined T4/T3 therapy. The same applied to LDL cholesterol (table 3 ). Table 2 Serum free thyroid hormone and TSH, FT3/FT4 ratio

Article Type:
Letter
DOI:
https://doi.org/10.1159/000337977
Volume/Issue:
Volume 1: Issue 2
Free access
Salman Razvi Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom

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Vicky Ryan Institute of Health and Society, Newcastle University, Newcastle, United Kingdom

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Lorna Ingoe Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

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Simon H. Pearce Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

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Scott Wilkes School of Medicine, University of Sunderland, Sunderland, United Kingdom

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individuals over 80 years [ 34 ]. The other novel finding of our study is that the FT3/FT4 ratio increased slightly on average in the HT arm, despite the reduction in exogenous thyroid hormone dose. While this phenomenon has been noted previously with

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000504047
Volume/Issue:
Volume 9: Issue 1
Free access
Leonidas Duntas Evgenideion Hospital, Unit of Endocrinology, Diabetes and Metabolism, National and Kapodeistrian University of Athens, Greece

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be lower in the Se than in the placebo group, but Se did not affect LT4 dosage or FT3/FT4 ratio nor did the duration of disease modify any parameter. The statistically significant reduction ( P < 0.016) of the pathognomonic TPOAb titers in this study

Article Type:
Commentary
Collections:
Thyroid autoimmunity
DOI:
https://doi.org/10.1530/ETJ-24-0038
Volume/Issue:
Volume 13: Issue 2
Open access
Salman Razvi Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK

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Avais Jabbar Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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Arjola Bano Department of Cardiology, Institute of Social and Preventive Medicine, University of Bern, Bern University Hospital, Bern, Switzerland

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Lorna Ingoe Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, UK

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Peter Carey Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Shahid Junejo Departments of Endocrinology and Cardiology, South Tyneside and Sunderland NHS Foundation Trust, Sunderland, UK

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Honey Thomas Department of Cardiology, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK

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Caroline Addison Department of Biochemistry, Gateshead Health NHS Foundation Trust, Gateshead, UK

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David Austin Department of Cardiology, South Tees Health NHS Foundation Trust, Middlesbrough, UK

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John P Greenwood Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK

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Azfar G Zaman Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

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. Relationship between serum TSH and FT4 with CRP and all-cause mortality There was no significant independent association between serum TSH levels ( P  = 0.11) nor FT4 concentrations ( P  = 0.08) with CRP levels at baseline, whereas the FT3/FT4 ratio was

Article Type:
Research Article
Collections:
Metabolic and cardiovascular effects of thyroid hormone
DOI:
https://doi.org/10.1530/ETJ-21-0085
Volume/Issue:
Volume 11: Issue 2
Open access
Alessandro Brancatella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Nicola Viola Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Sandra Brogioni Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Lucia Montanelli Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Chiara Sardella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Claudio Marcocci Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Isabella Lupi Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Francesco Latrofa Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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. weeks to years), 131 I uptake (low vs. high), FT3/FT4 ratio (low vs. high), and vascular pattern at color Doppler (low vs. high) (Table 2 ). Table 2. Destructive thyroiditis and Graves’ hyperthyroidism during ICPi therapy: differential

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000501824
Volume/Issue:
Volume 8: Issue 4
Free access
Giulia Brigante Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Giorgia Spaggiari Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Daniele Santi Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Katia Cioni Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Valentina Gnarini Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Chiara Diazzi Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Elisa Pignatti Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia

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Livio Casarini Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia

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Marco Marino Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia

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Frank Tüttelmann Institute of Human Genetics, University of Munster, Munster, Germany

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Cesare Carani Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Azienda USL, Modena, Italy

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Manuela Simoni Unit of Endocrinology and Metabolism, Department of Biomedical, Metabolic and Neural Sciences
Center of Genomic Research, University of Modena and Reggio Emilia
Azienda USL, Modena, Italy

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, there were no differences among the three groups (respectively p = 0.71; p = 0.34). No significant differences were found in serum levels of fT 3 (p = 0.59), fT 4 (p = 0.16), Ab anti-TG (p = 0.48), fT 3 /fT 4 ratio (p = 0.76) and fT 3 /TSH ratio (p

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000358590
Volume/Issue:
Volume 3: Issue 2
Free access
Jacqueline Jonklaas Division of Endocrinology, Georgetown University, Washington, District of Columbia, USA

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Antonio C. Bianco Section of Adult and Pediatric Endocrinology and Metabolism, University of Chicago, Chicago, Illinois, USA

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Anne R. Cappola Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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Francesco S. Celi Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA

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Eric Fliers Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands

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Heike Heuer Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Elizabeth A. McAninch Division of Endocrinology, Rush University, Chicago, Illinois, USA

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Lars C. Moeller Department of Endocrinology, Diabetes and Metabolism, University Duisburg-Essen, Essen, Germany

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Birte Nygaard Center for Endocrinology and Metabolism, Department of Internal Medicine, Herlev and Gentofte Hospitals, Herlev, Denmark

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Anna M. Sawka Division of Endocrinology, University Health Network and University of Toronto, Toronto, Ontario, Canada

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Torquil Watt Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Colin M. Dayan Thyroid Research Group, School of Medicine, Cardiff University, Cardiff, United Kingdom

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were more associated with clinical parameters such as atrial fibrillation, osteoporosis, cancer, and dementia than with TSH values even within the reference range [ 86 ]. The fT3:fT4 Ratio Is Altered on TH Replacement with LT4, Even with Similar TSH

Article Type:
Guideline
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000512970
Volume/Issue:
Volume 10: Issue 1
Free access
Rudolf Hoermann Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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John E.M. Midgley North Lakes Clinical, Ilkley, UK

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Rolf Larisch Department of Nuclear Medicine, Klinikum Luedenscheid, Luedenscheid, Germany

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Johannes W. Dietrich Medical Department I, Endocrinology and Diabetology, Bergmannsheil University Hospitals, Ruhr University of Bochum
Ruhr Center for Rare Diseases (CeSER), Ruhr University of Bochum and Witten/Herdecke University, Bochum, Germany

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ELISA (Anti-TSH-Receptor; EUROIMMUN AG, Luebeck, Germany). Interrelational Measures As a simple estimate of the conversion of T 4 to T 3 , we used the FT 3 -FT 4 ratio of the molar serum concentrations of the hormones. We divided FT 4 by TSH

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000447967
Volume/Issue:
Volume 5: Issue 3
Free access
Christian Trummer Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Hannes Reiher Department of Internal Medicine, Krankenhaus der Elisabethinen, Graz, Austria

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Verena Theiler-Schwetz Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Marlene Pandis Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Christian Gstettner Division of Nuclear Medicine, Department of Radiology, Medical University of Graz, Graz, Austria

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Peter Potzinger Department of Otorhinolaryngology, Krankenhaus der Elisabethinen, Graz, Austria

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Tilman Keck Department of Otorhinolaryngology, Krankenhaus der Elisabethinen, Graz, Austria

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Thomas R. Pieber Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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Sigurd Lax Department of Pathology, General Hospital Graz Sued-West, Graz, Austria
Institute of Pathology, Medical University of Graz, Graz, Austria
Institute for Clinical Pathology, Johannes Kepler University, Linz, Austria

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Johannes Haybaeck Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria

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Vinzenz Stepan Department of Internal Medicine, Krankenhaus der Elisabethinen, Graz, Austria

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Stefan Pilz Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria

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-GSU/TSH molar ratio is increased in most TSH-PitNETs [ 13 ]. Furthermore, increased serum concentrations of SHBG and bone turnover markers as well as an increased fT3/fT4 ratio were found to be indicative of autonomously TSH-secreting tumors. Additionally

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000505020
Volume/Issue:
Volume 9: Issue 2
Free access