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not been described prior to the present case report. What Does This Case Report Add? The association between albinism and Hashimoto’s thyroiditis in two brothers suggests a possible pathogenetic link between the two conditions
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Introduction Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disease characterized by goitre, lymphoplasmacytic infiltration of parenchyma, and positivity for serum antibodies specific to thyroid antigens (including thyroid
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the status of other trace elements [ 6 ]. The interplay with iodine and iron has since been elaborated, in particular for Hashimoto’s thyroiditis (HT) [ 7 ]. The clinical importance of selenium status for thyroid hormone metabolism may be limited in
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The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel
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as propylthiouracil and methimazole are additional reasons for transient hypothyroidism in the offspring ( 12 , 13 ). Maternal Hashimoto’s thyroiditis is associated with transient hypothyroidism or hyperthyrotropinemia of the newborn due to the
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manifestations of AITD are Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). The additional, less prevalent AITDs include postpartum thyroiditis, drug-induced thyroiditis, thyroiditis associated with polyglandular autoimmune syndromes ( 2 ). Both HT and GD
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
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Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
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Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Public Health Unit, ACES Baixo Mondego, Coimbra, Portugal
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Department of Endocrinology, Hospital University Centre of São João, Porto, Portugal
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Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Health Investigation and Innovation Institute (i3S), University of Porto, Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal
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Introduction Autoimmune thyroid disease (AITD) is one of the most prevalent groups of autoimmune diseases ( 1 ). Hashimoto’s thyroiditis (HT) and Graves' disease (GD) are the most significant AITDs ( 2 ), GD being around ten times less common
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results for 10 TBAb-positive/TSAb-negative samples from patients with autoimmune thyroid disease (either Hashimoto’s thyroiditis or Graves’ disease) Monoclonal Antibodies Mixtures of 100% K1–70 (200 ng/mL), 80% K1–70 (160 ng/mL) + 20% M22 (4
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Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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College of Life Science, University of the Chinese Academy of Sciences, Beijing, China
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Introduction Thyroglobulin antibodies (TgAb), frequently found in healthy individuals, are serological markers of both Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) [ 1 ]. In papillary thyroid carcinoma (PTC), the rate of TgAb
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, 21 ]. The spectrum of TA following HIV/HAART is reported as around 88% GD, 6% Hashimoto’s thyroiditis, and 6% hypothyroidism (negative for thyroid autoantibodies) [ 15 ]. Following allogeneic BMT/HSCT subclinical or clinical hypothyroidism occurs in
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Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT<sub>4</sub>) and may provide other beneficial effects (e.g. on mood and health-related quality of life). The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched The Cochrane Library, MEDLINE, EMBASE and Web of Science for randomized controlled trials. Study selection, data extraction, assessment of risk of bias and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. Four studies rated at unclear to high risk of bias comprising 463 participants were included. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium selenite 200 μg plus titrated LT<sub>4</sub> compared with placebo plus titrated LT<sub>4</sub> (RR 4.67, 95% CI 1.61-13.50). Selenomethionine 200 μg as a single treatment or combined with LT<sub>4</sub> reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo (or placebo plus LT<sub>4</sub>) in three studies (p < 0.001). Although the changes from baseline were statistically significant in these three studies, their clinical relevance is unclear. In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making.
