M. Schlumberger
M. Schlumberger
Department of Nuclear Medicine and Endocrine Oncology, Institute Gustave-Roussy and University Paris Sud, Villejuif, France
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L. Bastholt
L. Bastholt
Department of Oncology, Odense University Hospital, Odense, Denmark
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H. Dralle
H. Dralle
Department of Surgery, Martin Luther University, Halle-Wittenberg Medical Faculty, Halle/Saale, Germany
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B. Jarzab
B. Jarzab
MSC Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
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F. Pacini
F. Pacini
Department of Endocrinologia, University of Siena, Siena, Italy
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J.W.A. Smit
J.W.A. Smit
Department of Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
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Methods of Development of Evidence-Based Guidelines The European Thyroid Association (ETA) Executive Committee launched a taskforce to produce guidelines on the treatment of metastatic medullary thyroid cancer (MTC). A chairperson was selected
R. Elisei
R. Elisei
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
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M. Alevizaki
M. Alevizaki
Endocrine Unit, Department of Medical Therapeutics, Athens University School of Medicine, Athens, Greece
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B. Conte-Devolx
B. Conte-Devolx
Department of Endocrinology, La Timone Hospital, Aix Marseille University, Marseille, France
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K. Frank-Raue
K. Frank-Raue
Endocrine Practice, Molecular Laboratory, Heidelberg, Germany
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V. Leite
V. Leite
Department of Endocrinology, Portuguese Institute of Oncology and CEDOC, Faculty of Medical Sciences, Lisbon, Portugal
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G.R. Williams
G.R. Williams
Molecular Endocrinology Group, Department of Medicine, Hammersmith Hospital, Imperial College London, London, UK
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Introduction Several guidelines have already been published on the diagnosis, management, and treatment of medullary thyroid cancer (MTC) [ 1 , 2 , 3 , 4 ], but there are no guidelines devoted specifically to RET genetic screening in
Lars Bastholt
Lars Bastholt
Department of Oncology R, Odense University Hospital, Odense, Denmark
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Michael C. Kreissl
Michael C. Kreissl
Department of Nuclear Medicine, Augsburg Hospital, Augsburg
Department of Nuclear Medicine, University Hospital Würzburg, Würzburg
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Department of Nuclear Medicine, University Hospital Würzburg, Würzburg
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Dagmar Führer
Dagmar Führer
Department of Endocrinology and Metabolism, University Hospital Essen, Essen, Germany
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Ana L. Maia
Ana L. Maia
Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Porto Alegre
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Laura D. Locati
Laura D. Locati
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan
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Léa Maciel
Léa Maciel
Hospital das Clínicas de Ribeirăo Preto, Ribeirăo Preto, Brazil
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Yi Wu
Yi Wu
Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
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Kevin N. Heller
Kevin N. Heller
AstraZeneca, Gaithersburg, Md., USA
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Alan Webster
Alan Webster
AstraZeneca, Macclesfield, UK
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Rossella Elisei
Rossella Elisei
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Introduction Medullary thyroid cancer (MTC) is a malignancy of the parafollicular C cells of the thyroid gland, and it accounts for an estimated 4% of thyroid cancers [ 1 , 2 ]. MTC can only be cured by surgery and, until recently, the
Laura Moss
Laura Moss
Velindre Cancer Centre, Velindre University NHS Trust, Cardiff, United Kingdom
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Catrin Cox
Catrin Cox
Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
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Jonathan Wadsley
Jonathan Wadsley
Weston Park Cancer Centre, Sheffield, United Kingdom
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Kate Newbold
Kate Newbold
The Royal Marsden NHS Foundation Trust, London, United Kingdom
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Mark W.J. Strachan
Mark W.J. Strachan
Western General Hospital, Edinburgh, United Kingdom
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Maralyn Druce
Maralyn Druce
Barts and the London School of Medicine and Dentistry, London, United Kingdom
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Neil Tolley
Neil Tolley
Imperial College Healthcare NHS Trust, London, United Kingdom
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Kathryn Graham
Kathryn Graham
Beatson Oncology Centre, Glasgow, United Kingdom
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Sarah Jefferies
Sarah Jefferies
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
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Lydia Fresco
Lydia Fresco
University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
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Suganya Sivabalasingham
Suganya Sivabalasingham
University College Hospital NHS Foundation Trust, London, United Kingdom
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Alistair Balfour
Alistair Balfour
East Kent Hospitals University NHS Foundation Trust, Canterbury, United Kingdom
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Chris Hurt
Chris Hurt
Centre for Trials Research, Cardiff University, Cardiff, United Kingdom
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Introduction Medullary thyroid cancer (MTC) is a rare variant of thyroid cancer with different aetiology, presentation, treatment and symptoms compared to the more common differentiated thyroid cancers (DTC). Based on Cancer Research UK (CRUK
Zoe A. Efstathiadou
Zoe A. Efstathiadou
Department of Endocrinology, “Hippokration” General Hospital of Thessaloniki, Thessaloniki, Greece
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Charalambos Tsentidis
Charalambos Tsentidis
Department of Endocrinology, General Hospital of Nikaia “Agios Panteleimon”, Piraeus, Greece
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Alexandra Bargiota
Alexandra Bargiota
Department of Endocrinology, University of Thessaly, Larisa, Greece
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Vasiliki Daraki
Vasiliki Daraki
Department of Endocrinology, University Hospital of Crete, Heraklion, Greece
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Kalliopi Kotsa
Kalliopi Kotsa
Department of Endocrinology, “Ahepa” Hospital, Aristotle University, Thessaloniki, Greece
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Georgia Ntali
Georgia Ntali
Department of Endocrinology, Diabetes and Metabolism, “Evangelismos” Hospital Athens, Athens, Greece
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Labrini Papanastasiou
Labrini Papanastasiou
Department of Endocrinology and Diabetes Center, Athens General Hospital “G. Gennimatas”, Athens, Greece
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Stelios Tigas
Stelios Tigas
Department of Endocrinology, University of Ioannina, Ioannina, Greece
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Konstantinos Toulis
Konstantinos Toulis
Department of Endocrinology, 424 Military Hospital, Thessaloniki, Greece
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Kalliopi Pazaitou-Panayiotou
Kalliopi Pazaitou-Panayiotou
Division of Endocrinology, Endocrine Oncology, Interbalkan Medical Center, Thessaloniki, Greece
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Maria Alevizaki
Maria Alevizaki
Endocrine Unit, Department of Medical Therapeutics, School of Medicine, Kapodistrian University of Athens, Athens, Greece
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Introduction Medullary thyroid cancer (MTC) is a malignant tumor arising from the thyroid parafollicular C cells. It is considered a rare neoplasm since it accounts for just 1–2% of all thyroid cancers [ 1 , 2 ]. Prognosis depends on disease
Carla Gambale
Carla Gambale
Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy
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Alessandro Prete
Alessandro Prete
Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy
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Chiara Romei
Chiara Romei
Department of Diagnostic Imaging, Unit of Radiology, Pisa University Hospital, Pisa, Italy
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Alessandro Celi
Alessandro Celi
Department of Surgery, Medicine, Molecular Biology and Critical Care, Respiratory Pathophysiology Unit, Pisa University Hospital, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Unit of Endocrinology, Pisa University Hospital, Pisa, Italy
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Established facts Selpercatinib, a highly selective RET inhibitor, has demonstrated notable efficacy in advanced/progressive RET-mutant medullary thyroid cancer patients. Despite a more tolerable toxicity profile than multikinase
Camille Buffet
Camille Buffet
Department of Thyroid Pathologies and Endocrine Tumors, AP-HP, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, Sorbonne Université, Paris, France
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
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UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institut, Villejuif, France
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Françoise Kraeber-Bodéré
Françoise Kraeber-Bodéré
Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France
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CHU Nantes/ICO, Saint-Herblain, France
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Caroline Bodet-Milin
Caroline Bodet-Milin
Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France
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CHU Nantes/ICO, Saint-Herblain, France
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Laure Cabanes
Laure Cabanes
Department of Cardiology, APHP, Cochin Hospital, Paris, France
Université de Paris, Paris, France
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Université de Paris, Paris, France
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Anthony Dohan
Anthony Dohan
Radiology Department, Université de Paris, Paris, France
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France
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Department of Radiology, AP-HP, Hôpital Cochin, Paris, France
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Pascal Leprince
Pascal Leprince
Department of Thoracic and Cardiovascular Surgery, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
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Martin Schlumberger
Martin Schlumberger
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France
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Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France
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Olivier Huillard
Olivier Huillard
Université de Paris, Sorbonne Paris Cité, Paris, France
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France
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Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France
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Lionel Groussin
Lionel Groussin
INSERM Unité 1016, CNRS UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France
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Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France
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from medullary thyroid cancers (MTC) are uncommon. Their frequency in large autopsy series in patients with thyroid cancers is low, between 0 and 5% [ 1 - 5 ]. Given the rarity of this metastatic location, the outcome remains unclear. The average length
Simona Censi
Simona Censi
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Jacopo Manso
Jacopo Manso
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Teresa Benvenuti
Teresa Benvenuti
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Ilaria Piva
Ilaria Piva
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Maurizio Iacobone
Maurizio Iacobone
Endocrine Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
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Alberto Mondin
Alberto Mondin
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Francesca Torresan
Francesca Torresan
Endocrine Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
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Daniela Basso
Daniela Basso
Laboratory Medicine, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Gino Crivellari
Gino Crivellari
Hereditary Tumor Unit, Istituto Oncologico Veneto, IOV - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
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Stefania Zovato
Stefania Zovato
Hereditary Tumor Unit, Istituto Oncologico Veneto, IOV - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
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Caterina Mian
Caterina Mian
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Introduction Medullary thyroid cancer (MTC) originates from parafollicular C-cells and represents 2% of all thyroid malignancies and 0.4–1.4% of all thyroid nodules ( 1 ). MTC is sporadic in 75–80% of cases or manifests as a hereditary tumor
Luciana Puleo
Luciana Puleo
Endocrine Unit, Department of Clinical and Experimental Medicine
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Laura Agate
Laura Agate
Endocrine Unit, Department of Clinical and Experimental Medicine
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Irene Bargellini
Irene Bargellini
Department of Vascular and Interventional Radiology
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Giuseppe Boni
Giuseppe Boni
Regional Center of Nuclear Medicine
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Paolo Piaggi
Paolo Piaggi
Endocrine Unit, Department of Clinical and Experimental Medicine
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Claudio Traino
Claudio Traino
Regional Center of Nuclear Medicine
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Tommaso Depalo
Tommaso Depalo
Regional Center of Nuclear Medicine
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Giulia Lorenzoni
Giulia Lorenzoni
Department of Vascular and Interventional Radiology
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Francesca Bianchi
Francesca Bianchi
Regional Center of Nuclear Medicine
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Duccio Volterrani
Duccio Volterrani
Regional Center of Nuclear Medicine
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Sandra Brogioni
Sandra Brogioni
Endocrine Unit, Department of Clinical and Experimental Medicine
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Valeria Bottici
Valeria Bottici
Endocrine Unit, Department of Clinical and Experimental Medicine
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Maurizia Rossana Brunetto
Maurizia Rossana Brunetto
Hepatology Unit, University of Pisa, Pisa, Italy
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Barbara Coco
Barbara Coco
Hepatology Unit, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Endocrine Unit, Department of Clinical and Experimental Medicine
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Rossella Elisei
Rossella Elisei
Endocrine Unit, Department of Clinical and Experimental Medicine
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Introduction Medullary thyroid cancer (MTC) is a neuroendocrine tumor arising from parafollicular or calcitonin-producing C cells that retain the biochemical and pathological features of the cells from which it derives. MTC accounts for 3
Grace Segall
Grace Segall
Eli Lilly and Company, Indianapolis, IN, USA
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Ravinder Singh
Ravinder Singh
Eli Lilly and Company, Indianapolis, IN, USA
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Min-Hua Jen
Min-Hua Jen
Eli Lilly and Company, Indianapolis, IN, USA
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Isaac Sanderson
Isaac Sanderson
Adelphi Real World, Bollington, UK
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Alex Rider
Alex Rider
Adelphi Real World, Bollington, UK
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Katie Lewis
Katie Lewis
Adelphi Real World, Bollington, UK
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Urpo Kiiskinen
Urpo Kiiskinen
Eli Lilly and Company, Indianapolis, IN, USA
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Introduction Medullary thyroid cancer (MTC) is a rare neuroendocrine tumour derived from calcitonin-secreting parafollicular C cells ( 1 ) and accounts for approximately 2‒4% of thyroid cancers ( 2 , 3 , 4 , 5 ) but up to 15% of thyroid
