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Kira Bang Bové Department of Endocrinology, Odense, Denmark

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Torquil Watt Department of Endocrinology, Odense, Denmark
Institute of Public Health, University of Copenhagen, Odense, Denmark

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Asmus Vogel Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Jakob Bue Bjoerner Institute of Public Health, University of Copenhagen, Odense, Denmark
National Research Centre for the Working Environment, Copenhagen, Odense, Denmark

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Mogens Groenvold Institute of Public Health, University of Copenhagen, Odense, Denmark
Department of Palliative Medicine, Bispebjerg Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Åse Krogh Rasmussen Department of Endocrinology, Odense, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology, Odense, Denmark

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patients with another chronic thyroid disease, in this case nodular goitre. Furthermore, we aimed at identifying potential clinical and socio-demographic determinants of anxiety and depression in patients with Graves' disease. Material and Methods

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Luigi Bartalena Department of Medicine and Surgery, University of Insubria, Varese, Italy

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Fausto Bogazzi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Luca Chiovato Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri and University of Pavia, Pavia, Italy

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland

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Thera P. Links Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Mark Vanderpump Physicians’ Clinic, London, United Kingdom

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gland with pre-existing abnormalities (nodular goitre, latent Graves disease, chronic autoimmune thyroiditis) [ 2 ]. The epidemiology of AIT has changed over a period of 25 years in Italy, as the prevalence of AIT due to destructive thyroiditis (see

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Andrea Frasoldati Division of Endocrinology, Arcispedale S. Maria Nuova, Reggio Emilia, Italy

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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Enrico Papini Division of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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practice of European thyroidologists. Hence, we carried out a survey among European Thyroid Association (ETA) members aimed at investigating the attitude of ETA members towards the use of MIT in diagnosis/therapy of symptomatic nodular goitre. Imitating

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Johannes Järhult Department of Surgery, Highland Hospital, Eksjö, Sweden
Department of Surgery, County Hospital Ryhov, Jönköping, Sweden

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Ramtin Vedad Department of Surgery, County Hospital Ryhov, Jönköping, Sweden

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The main histological diagnosis was nodular goitre in 83% of the operated patients, follicular adenoma in 10%, thyroid carcinoma in 5% and thyroid cyst in 1%. Altogether, 27 patients (5.7%) developed thyrotoxicosis during the follow-up period (6

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Jesper Roed Sorensen Department of ORL Head and Neck Surgery, Odense University Hospital, Odense, Denmark
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark

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Jeppe Faurholdt Lauridsen Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark

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Helle Døssing Department of ORL Head and Neck Surgery, Odense University Hospital, Odense, Denmark

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Nina Nguyen Department of Radiology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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Christian Godballe Department of ORL Head and Neck Surgery, Odense University Hospital, Odense, Denmark

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Foundation, and S.B. was supported by grants from Odense University Hospital’s Research Council. References 1 Carlé A, Krejbjerg A, Laurberg P: Epidemiology of nodular goitre. Influence of iodine intake. Best Pract Res Clin Endocrinol Metab 2014

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Sampath Satish Kumar Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Sheila Fraser Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Andrew Scarsbrook Departments of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Ken MacLennan Leeds Institute of Molecular Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Mark Lansdown Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Robert D. Murray Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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commenced, and the dose titrated to normalise her thyroid function tests. The maintenance dose was 150 µg. Neck ultrasonography showed a large nodular goitre suspicious of malignancy. A staging computed tomography (CT) scan of the neck and thorax revealed a

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Nicholas Hope Royal Victoria Hospital, Belfast, UK

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Andrew Kelly Royal Victoria Hospital, Belfast, UK

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case-note analysis of patients undergoing total thyroidectomy. The 2 groups of patients under study were those who had a diagnosis of Graves' disease and those diagnosed with toxic multi-nodular goitre (TMNG). By comparing these 2 groups, the authors

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Camilla Bøgelund Larsen Department of Endocrinology, Odense University Hospital, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Kristian Hillert Winther Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Per Karkov Cramon Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Åse Krogh Rasmussen Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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Nils Jakob Knudsen Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark

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Jakob Bue Bjorner Department of Public Health, Copenhagen University, Copenhagen, Denmark
QualityMetric Inc, Johnston, Lincoln, Rhode Island, USA

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Lutz Schomburg Institute for Experimental Endocrinology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Kamil Demircan Institute for Experimental Endocrinology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Thilo Samson Chillon Institute for Experimental Endocrinology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Jeppe Gram Medical Department, Endocrinology, University Hospital of South-West Jutland, Esbjerg, Denmark

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Stinus Gadegaard Hansen Medical Department, Endocrinology, University Hospital of South-West Jutland, Esbjerg, Denmark

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Frans Brandt Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Internal Medicine Research Unit, University Hospital of Southern Jutland, Aabenraa, Denmark

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Birte Nygaard Department of Endocrinology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

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Torquil Watt Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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serum TSH ≥4.0 mIU/L; and written informed consent. Exclusion criteria Exclusion criteria were previous diagnosis of toxic nodular goitre; Graves’ hyperthyroidism or orbitopathy; postpartum thyroiditis; previous radioiodine therapy or thyroid

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Filip Alsted Brinch Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark

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Helle Døssing Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark

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Nina Nguyen Department of Radiology, Odense University Hospital, Odense, Denmark

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Steen Joop Bonnema Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, Odense, Denmark

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Christian Godballe Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark

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Jesper Roed Sorensen Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark
OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark

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, Krejbjerg A , Laurberg P . Epidemiology of nodular goitre. Influence of iodine intake . Best Pract Res Clin Endocrinol Metab . 2014 Aug ; 28 ( 4 ): 465 – 79 . 10.1016/j.beem.2014.01.001 25047199 1521-690X 2 Gharib H , Papini E

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Carles Zafon Department of Endocrinology, Hospital Vall d'Hebron, and Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona and CIBERDEM (ISCIII), Barcelona

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Juan J. Díez Department of Endocrinology and Nutrition, Hospital Ramón y Cajal
Department of Medicine, University of Alcalá de Henares, Madrid

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Juan C. Galofré Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain
IdiSNA (Instituto de investigación en la salud de Navarra), Pamplona, Spain

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David S. Cooper Division of Endocrinology, Diabetes and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

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the follow-up of patients with thyroid cancer. Pupilli et al. [ 22 ] investigated the presence of the DNA BRAF mutation in plasma from 103 patients with nodular goitre and reported 65% specificity and 80% sensitivity to discriminate papillary thyroid

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