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, transport studies by LAT2 have mainly been performed in oocytes from Xenopus laevis [ 10 , 11 , 13 ]. Using this cell system and the known LAT inhibitor 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH) we observed a preferential uptake of 3,3′-T 2
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accurate marker of the ovarian reserve [ 9 ]. Before the in vitro phase of the ART procedure, ovarian stimulation (OS) is performed, aiming to collect as many oocytes as possible. OS leads to an increase in oestradiol levels and consequently thyroxine
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] characterized NTCP expressed in Xenopus oocytes as a TH transporter. NTCP is an integral membrane protein of the ASBT family and takes up taurocholic acid in a symport mechanism with sodium. NTCP is exclusively expressed in hepatocytes where it participates in
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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life span and, in some women, progress to premature ovarian insufficiency. Reduced ovarian reserve may present as a decreased reproductive capacity or reduced oocyte quality and quantity ( 12 ). The anti-Müllerian hormone (AMH) measured in serum is a
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-type amino acid transporter 2 (LAT2) or the organic anion-transporting polypeptide 1c1 (Oatp1c1) exist. In this issue, Kinne and colleagues [pp. 42-50] describe a powerful oocyte cell system that the authors established to facilitate studies on the precise
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://doi.org/10.1093/humrep/des031 ) 32 Martinez M Rabadan S Domingo J Cobo A Pellicer A Garcia-Velasco JA . Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer . Reproductive Biomedicine Online
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Center for Interdisciplinary Research on Medicines (C.I.R.M.), University of Liege (ULiège), CHU (B35), Liege, Belgium
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Center for Interdisciplinary Research on Medicines (C.I.R.M.), University of Liege (ULiège), CHU (B35), Liege, Belgium
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Center for Interdisciplinary Research on Medicines (C.I.R.M.), University of Liege (ULiège), CHU (B35), Liege, Belgium
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, inducing an increase of intracellular levels of reactive oxygen species (ROS), leading to oxidative stress and DNA damage in mouse hepatocytes, primary nephrocytes, and oocytes ( 50 , 51 , 52 ). Since ROS production is increased in TC with respect to