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Min Ji Jeon Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Gu Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Ki-Wook Chung Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Jung Hwan Baek Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

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carcinomas (PTCs) including papillary thyroid microcarcinomas (PTMCs) [ 1 , 2 ]. For the last several decades, we did not have sufficient knowledge of the biological behavior of PTMCs, and were surprised to find that many of these PTMCs have similar

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F. Cecoli Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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E.M. Ceresola Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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V. Altrinetti Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cabria Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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M. Cappagli Endocrine Unit, Sant'Andrea Hospital, La Spezia

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A. Montepagani Endocrine Unit, Sant'Andrea Hospital, La Spezia

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C.M. Cuttica Endocrinology and Nuclear Medicine, Galliera Hospital, Genoa

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U. Filippi Evangelico Internazionale Hospital, Genoa

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D. Saverino Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Raffa Endocrine-Metabolic Center, ASL 1, Imperia, Italy

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M. Caputo Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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F. Minuto Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Giusti Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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M. Bagnasco Endocrinology, Nuclear Medicine and Autoimmunity Laboratory, Department of Internal Medicine, and Department of Experimental Medicine, Genoa University, and IRCCS Azienda Ospedaliera Universitaria San Martino - IST Genoa

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Introduction The incidence of papillary thyroid cancer (PTC) has almost doubled over the last three decades mainly due to the higher incidence of papillary thyroid microcarcinoma (MPTC) [ 1 , 2 ]. In Italy, a remarkably high PTC incidence has

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Maria Rossing Department of Endocrinology, Herlev University Hospital, Herlev
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Birte Nygaard Department of Endocrinology, Herlev University Hospital, Herlev

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Finn Cilius Nielsen Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark

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Finn Noe Bennedbæk Department of Endocrinology, Herlev University Hospital, Herlev

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Frates et al. [ 7 ] the accumulated predicted value of US characteristics and basic clinical features ranged between 3 and 48%. The papillary thyroid microcarcinoma (PTMC) is a papillary thyroid carcinoma with a size of ≤1 cm. The overall incidence of

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Ho-Ryun Won Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea

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Min Gyu Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Min Soo Kim Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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Jae Won Chang Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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Bon Seok Koo Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea
Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea

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increase in papillary thyroid microcarcinoma (PTMC), defined as papillary thyroid carcinoma less than 1 cm; accordingly, concerns have been raised regarding overdiagnosis ( 6 , 7 ). Another characteristic of thyroid cancer is indolent progression

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Giovanni Mauri Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy

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Laszlo Hegedüs Department of Endocrinology, Odense University Hospital, University of Southern Denmark, Odense, Denmark

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Steven Bandula Interventional Oncology Service, University College Hospital, London, United Kingdom

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Roberto Luigi Cazzato Department of Interventional Radiology, University Hospital of Strasbourg, Strasbourg, France

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Agnieszka Czarniecka The Oncologic and Reconstructive Surgery Clinic, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Oliver Dudeck Center for Microtherapy, Klinik Hirslanden, Zurich, Switzerland

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Laura Fugazzola Department of Endocrinology and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Romana Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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Gilles Russ Thyroid and Endocrine Tumors Unit, La Pitie-Salpetriere Hospital, Sorbonne University, Paris, France

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Göran Wallin Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

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Enrico Papini Department of Endocrinology & Metabolism, Ospedale Regina Apostolorum, Albano, Italy

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, if needed, by radioiodine ablation (RAI) [ 4 ]. But, a few issues remain unsettled. The growing incidental detection of papillary thyroid microcarcinomas (PTMCs) is paralleled by the progressive increase in surgical thyroid procedures [ 5 ]. Due to

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Matthieu Bosset Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Maxime Bonjour Service de Biostatistique, Hospices Civils de Lyon, Lyon, France

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Solène Castellnou Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Zakia Hafdi-Nejjari Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Claire Bournaud-Salinas Centre de Médecine Nucléaire, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Myriam Decaussin-Petrucci Service d’Anatomie-Pathologique, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France

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Jean Christophe Lifante Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France

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Agnès Perrin Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Jean-Louis Peix Service de Chirurgie Endocrinienne, Hospices Civils de Lyon, Groupement Hospitalier Lyon-Sud, Pierre Bénite, France

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Philippe Moulin Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France

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Geneviève Sassolas Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Michel Pugeat Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France

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Françoise Borson-Chazot Fédération d’Endocrinologie, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France

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Leboulleux S , Tuttle RM , Pacini F , Schlumberger M . Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance? Lancet Diabetes Endocrinol . 2016 Nov ; 4 ( 11 ): 933 – 42 . http://dx.doi.org/10.1016/S2213

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Pedro Marques Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Maria João Bugalho Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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cm or smaller and 87% consist of cancers measuring 2 cm or smaller [ 2 ]. The clinical course of small PTCs is generally favorable, especially when smaller than 1 cm (papillary thyroid microcarcinoma, PTMC) [ 3 , 4 ]. Nonetheless, a few cases may

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Pedro Weslley Souza Rosario Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Gabriela Franco Mourão Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Pedro Henrique Lopes Oliveira Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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Tulio Henrique Silva Santa Casa de Belo Horizonte, Belo Horizonte, Brazil

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microcarcinoma of the thyroid under observation. Thyroid 2014; 24: 27–34. 2 Fukuoka O, Sugitani I, Ebina A, Toda K, Kawabata K, Yamada K: Natural history of asymptomatic papillary thyroid microcarcinoma: time-dependent changes in calcification and

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Yalin Iscan Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Ismail Cem Sormaz Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Fatih Tunca Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Yasemin Giles Senyurek Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Surg . 2010 Oct ; 200 ( 4 ): 454 – 61 . 10.1016/j.amjsurg.2009.11.008 20561605 0002-9610 7 Pelizzo MR , Merante Boschin I , Toniato A , Piotto A , Bernante P , Pagetta C , et al. [Papillary thyroid microcarcinoma. Long

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Gilles Russ Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris-Sud, Villejuif, France

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Laurence Leenhardt Thyroid and Endocrine Tumor Unit, Department of Nuclear Medicine, Pitié Salpêtrière Hospital, University Pierre et Marie Curie, Paris, France

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Laszlo Hegedüs Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark

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: Papillary thyroid microcarcinoma: a study of 900 cases observed in a 60-year period. Surgery 2008;144:980-987, discussion 987-988. 10.1016/j.surg.2008.08.035 19041007 43 Ito Y, Miyauchi A, Inoue H, Fukushima M, Kihara M, Higashiyama T, Tomoda C

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