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carcinomas (PTCs) including papillary thyroid microcarcinomas (PTMCs) [ 1 , 2 ]. For the last several decades, we did not have sufficient knowledge of the biological behavior of PTMCs, and were surprised to find that many of these PTMCs have similar
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Introduction The incidence of papillary thyroid cancer (PTC) has almost doubled over the last three decades mainly due to the higher incidence of papillary thyroid microcarcinoma (MPTC) [ 1 , 2 ]. In Italy, a remarkably high PTC incidence has
Center of Genomic Medicine, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
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Frates et al. [ 7 ] the accumulated predicted value of US characteristics and basic clinical features ranged between 3 and 48%. The papillary thyroid microcarcinoma (PTMC) is a papillary thyroid carcinoma with a size of ≤1 cm. The overall incidence of
Department of Otorhinolaryngology-Head and Neck Surgery, Chungnam National University Sejong Hospital, Sejong, Republic of Korea
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Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
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Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea
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increase in papillary thyroid microcarcinoma (PTMC), defined as papillary thyroid carcinoma less than 1 cm; accordingly, concerns have been raised regarding overdiagnosis ( 6 , 7 ). Another characteristic of thyroid cancer is indolent progression
Division of Interventional Radiology, European Institute of Oncology, IRCCS, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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, if needed, by radioiodine ablation (RAI) [ 4 ]. But, a few issues remain unsettled. The growing incidental detection of papillary thyroid microcarcinomas (PTMCs) is paralleled by the progressive increase in surgical thyroid procedures [ 5 ]. Due to
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Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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CarMeN Laboratory, Université Claude-Bernard Lyon 1, Inserm U1060, INRA U1397, INSA Lyon, IMBL, Villeurbanne, France
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Registre des Cancers Thyroïdiens du Département du Rhône, Hospices Civils de Lyon, Groupement Hospitalier Est, Bron, France
Laboratoire Health Services and Performance Research (EA 7425 HESPER), Université Claude Bernard Lyon 1, Villeurbanne, France
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Leboulleux S , Tuttle RM , Pacini F , Schlumberger M . Papillary thyroid microcarcinoma: time to shift from surgery to active surveillance? Lancet Diabetes Endocrinol . 2016 Nov ; 4 ( 11 ): 933 – 42 . http://dx.doi.org/10.1016/S2213
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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cm or smaller and 87% consist of cancers measuring 2 cm or smaller [ 2 ]. The clinical course of small PTCs is generally favorable, especially when smaller than 1 cm (papillary thyroid microcarcinoma, PTMC) [ 3 , 4 ]. Nonetheless, a few cases may
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microcarcinoma of the thyroid under observation. Thyroid 2014; 24: 27–34. 2 Fukuoka O, Sugitani I, Ebina A, Toda K, Kawabata K, Yamada K: Natural history of asymptomatic papillary thyroid microcarcinoma: time-dependent changes in calcification and
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Surg . 2010 Oct ; 200 ( 4 ): 454 – 61 . 10.1016/j.amjsurg.2009.11.008 20561605 0002-9610 7 Pelizzo MR , Merante Boschin I , Toniato A , Piotto A , Bernante P , Pagetta C , et al. [Papillary thyroid microcarcinoma. Long
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: Papillary thyroid microcarcinoma: a study of 900 cases observed in a 60-year period. Surgery 2008;144:980-987, discussion 987-988. 10.1016/j.surg.2008.08.035 19041007 43 Ito Y, Miyauchi A, Inoue H, Fukushima M, Kihara M, Higashiyama T, Tomoda C