Ayanthi Wijewardene
Ayanthi Wijewardene
Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Matti Gild
Matti Gild
Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Carolina Nylén
Carolina Nylén
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Geoffrey Schembri
Geoffrey Schembri
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Paul Roach
Paul Roach
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Jeremy Hoang
Jeremy Hoang
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Ahmad Aniss
Ahmad Aniss
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Anthony Glover
Anthony Glover
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Mark Sywak
Mark Sywak
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Stan Sidhu
Stan Sidhu
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Diana Learoyd
Diana Learoyd
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Bruce Robinson
Bruce Robinson
Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Lyndal Tacon
Lyndal Tacon
Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Roderick Clifton-Bligh
Roderick Clifton-Bligh
Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
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]. Over 97% of thyroid cancer is well-differentiated, originating from thyroid follicular cells. Differentiated thyroid cancer includes papillary, follicular, or Hurthle-cell neoplasms [ 4 ]. Radioactive iodine (RAI) is considered following total
Sarah L. Lutterman
Sarah L. Lutterman
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Nitash Zwaveling-Soonawala
Nitash Zwaveling-Soonawala
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Hein J. Verberne
Hein J. Verberne
Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Frederik A. Verburg
Frederik A. Verburg
Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
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A.S. Paul van Trotsenburg
A.S. Paul van Trotsenburg
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Christiaan F. Mooij
Christiaan F. Mooij
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Introduction In adults and children, hyperthyroidism is mostly caused by Graves’ disease (GD) [ 1 , 2 ]. Treatment options for GD include antithyroid drugs (ATDs), thyroidectomy, and radioactive iodine (RAI). In Europe, ATDs are the preferred
Luigino Dal Maso
Luigino Dal Maso
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Daniela Pierannunzio
Daniela Pierannunzio
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Silvia Francisci
Silvia Francisci
National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy
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Angela De Paoli
Angela De Paoli
Epidemiological Department, Azienda Zero, Padova, Italy
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Federica Toffolutti
Federica Toffolutti
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Salvatore Vaccarella
Salvatore Vaccarella
Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France
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Silvia Franceschi
Silvia Franceschi
Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy
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Ugo Fedeli
Ugo Fedeli
Epidemiological Department, Azienda Zero, Padova, Italy
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of the DEPTH Working Group
of the DEPTH Working Group
of the DEPTH Working Group
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Introduction Radioactive iodine (RAI) treatment may be used after total thyroidectomy (TT) for thyroid cancer for several purposes: remnant ablation to facilitate detection of recurrent disease, adjuvant treatment of subclinical residual tumor
Jean-Charles Martin
Jean-Charles Martin
Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France
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Thierry Pourcher
Thierry Pourcher
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Guillaume Phan
Guillaume Phan
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
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Julien Guglielmi
Julien Guglielmi
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Caroline Crambes
Caroline Crambes
Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France
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François Caire-Maurisier
François Caire-Maurisier
Pharmacie Centrale des Armées (PCA), Direction des Approvisionnements en produits de Santé des Armées, Fleury-les-Aubrais, France
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Dalila Lebsir
Dalila Lebsir
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
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David Cohen
David Cohen
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
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Clément Rosique
Clément Rosique
Centre de recherche en CardioVasculaire et Nutrition (C2VN), Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Institut National pour la Santé Et la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Marseille, France
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Lun Jing
Lun Jing
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Maha Hichri
Maha Hichri
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Lisa Salleron
Lisa Salleron
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Jacques Darcourt
Jacques Darcourt
Transporter in Imaging and Radiotherapy in Oncology Laboratory (TIRO), Direction de la Recherche Fondamentale (DRF), Institut des sciences du vivant Frederic Joliot, Commissariat à l’Energie Atomique et aux Energies alternatives (CEA), Université Côte d’Azur (UCA), School of Medicine, Nice, France
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Maamar Souidi
Maamar Souidi
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
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Marc Benderitter
Marc Benderitter
Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-Santé, Fontenay-aux-Roses, France
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years ( 1 ). It aimed to define the conditions for repetitive administration of potassium iodide (KI) in order to protect the population undergoing prolonged exposure to radioactive iodine in a nuclear or radiological accidental situation. The results
Sébastien Verdickt
Sébastien Verdickt
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Falco Van Nes
Falco Van Nes
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Carolien Moyson
Carolien Moyson
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Toon Maes
Toon Maes
Department of Endocrinology, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium
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Paul Van Crombrugge
Paul Van Crombrugge
Department of Endocrinology, OLV Ziekenhuis Aalst-Asse-Ninove, Aalst, Belgium
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Annick Van den Bruel
Annick Van den Bruel
Department of Endocrinology, AZ Sint Jan Brugge, Brugge, Belgium
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology, University Hospitals of Leuven, Leuven, Belgium
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Introduction Radioactive iodine (RAI) has been used for the treatment of patients with Graves’ hyperthyroidism since the 1950s. After a single RAI administration, patients ideally become euthyroid but frequently develop hypothyroidism. On the
Fernanda Andrade
Fernanda Andrade
Department of Medicine, Endocrinology Service, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Danielle Probstner
Danielle Probstner
Department of Orthopedics and palliative care, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Marcus Decnop
Marcus Decnop
Department of Radiology, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Daniel Bulzico
Daniel Bulzico
Department of Medicine, Endocrinology Service, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
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Denise Momesso
Denise Momesso
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Rossana Corbo
Rossana Corbo
Department of Medicine, Endocrinology Service, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Mario Vaisman
Mario Vaisman
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Fernanda Vaisman
Fernanda Vaisman
Department of Medicine, Endocrinology Service, Instituto Nacional do Cancer (INCA), Rio de Janeiro, Brazil
Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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Department of Medicine, Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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radiation, thermal ablation, and cement injections [ 10 - 12 ]. Although rarely curative, radioactive iodine therapy (RAI) is recommended for all patients with bone metastases and may benefit individuals with RAI avid bone lesions. However, there is no
Furio Pacini
Furio Pacini
Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Siena, Italy
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The initial treatment of differentiated thyroid cancer consists of total or near-total thyroidectomy. Surgery is usually followed by the administration of radioactive iodine activities (RAI) aimed to ablate any remnant thyroid tissue and
Steen J. Bonnema
Steen J. Bonnema
Departments of Endocrinology, Odense University Hospital, Odense
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Elisabeth S. Stovgaard
Elisabeth S. Stovgaard
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
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Søren Fast
Søren Fast
Departments of Endocrinology, Odense University Hospital, Odense
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Kasper Broedbaek
Kasper Broedbaek
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
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Jon T. Andersen
Jon T. Andersen
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
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Allan Weimann
Allan Weimann
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
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Peter Grupe
Peter Grupe
Departments of Nuclear Medicine, Odense University Hospital, Odense
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Laszlo Hegedüs
Laszlo Hegedüs
Departments of Endocrinology, Odense University Hospital, Odense
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Henrik E. Poulsen
Henrik E. Poulsen
Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
Department of Clinical Pharmacology, Bispebjerg Hospital
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Clinical Pharmacology, Bispebjerg Hospital
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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Introduction For many years radioactive iodine ( 131 I) has been used for treatment of nontoxic goiter, hyperthyroidism and thyroid cancer. During the last decade recombinant human TSH (rhTSH) - a very potent stimulator of the thyroid 131 I
Shi Hui Junice Wong
Shi Hui Junice Wong
Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore
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Insights Lymphadenitis can occur in association with RAI therapy for Graves’ disease. This can progress to abscess formation requiring surgical drainage. Introduction The use of radioactive iodine or iodine-131 (I-131) in the
Stasa Ivkovic
Stasa Ivkovic
Clinical Center of Serbia, Clinic of Otorhinolaryngology and Maxillofacial Surgery, Belgrade, Serbia
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Dear Sir, Five months after radioactive iodine treatment for Graves’ hyperthyroidism, I developed severe hypothyroidism. Three months after treatment, TSH, FT4 and FT3 values were within reference range (0.44 mlU/l, 15.9 and 4.5 pmol
