Objective: The prognostic value of stimulated thyroglobulin (sTg) and Tg-related parameters prior to and immediately after radioactive iodine (RAI) administration was assessed in a cohort of patients presenting with differentiated thyroid cancer (DTC) as a predictor of recurrent or progressive structural disease. Methods: Clinical records of 180 DTC patients were retrospectively reviewed, and serum TSH, Tg, and Tg antibodies were recorded just before RAI administration (pre-) and at the time of whole body scanning (post-). Based on the results of initial staging and RAI scintigraphy, patients were divided into two groups: those who were considered to be structurally disease-free after thyroidectomy and RAI (group 1) and those who were not (group 2). Univariate analyses were performed for pre-Tg, ratioTg (post-Tg/pre-Tg), and other clinical and pathological markers for long-term outcome, as well as separate bivariate analyses focusing on pre-Tg to correct for possible confounders. Different pre-Tg cut-off values for predicting structural disease recurrence were assessed in a subgroup of patients in group 1 prepared with thyroid hormone withdrawal. Results: In group 1, (n = 166) male gender, higher T-stage and both Tg-related parameters proved to be significant risk factors for structural disease relapse. Of all candidate variables, only higher T-stage served to predict progressive structural disease in group 2 (n = 14). Subgroup analysis showed a negative predictive value of 91.67% for pre-Tg < 10 µg/L. Conclusion: The sTg value at the time of RAI administration may be helpful in predicting structural disease recurrence in patients with DTC.
Mathieu Spaas, Brigitte Decallonne, Annouschka Laenen, Jaak Billen, and Sandra Nuyts
Fabián Pitoia, Fernando Jerkovich, Anabella Smulever, Gabriela Brenta, Fernanda Bueno, and Graciela Cross
following that interval in all cases with TSH levels above 50 mIU/L. Thyroglobulin/Thyroidglobulin Antibody Measurement Samples for thyroglobulin (Tg) and thyroglobulin antibody (TgAb) measurement were obtained on the day of ablative radioiodine
R. Paschke, M. Niedziela, B. Vaidya, L. Persani, B. Rapoport, and J. Leclere
of the thyroid tissue by total thyroidectomy followed by radioiodine administration is strongly recommended. (2) Antithyroid drugs should only be used to prepare the patients for surgery. β-Blocking drugs (propranolol) should be used in order to
Syed Ali Imran, Karen Chu, Murali Rajaraman, Drew Rajaraman, Sunita Ghosh, Sarah De Brabandere, Stephanie M. Kaiser, and Stan Van Uum
.1054/bjoc.2001.2173 11747326 0007-0920 21 Rachinsky I , Rajaraman M , Leslie WD , Zahedi A , Jefford C , McGibbon A , et al. Regional Variation across Canadian Centers in Radioiodine Administration for Thyroid Remnant Ablation in
Fabián Pitoia, Erika Abelleira, and Graciela Cross
criteria (patients with T4 and N1). A low-iodine diet was prescribed, from 1 week before radioiodine administration until 2 days afterwards. Within the rhTSH group, 17 patients received 100 mCi and 3 patients received 150 mCi, while within the THW group
Furio Pacini, Dagmar Fuhrer, Rossella Elisei, Daria Handkiewicz-Junak, Sophie Leboulleux, Markus Luster, Martin Schlumberger, and Johannes W Smit
-operative radioiodine administration ( 24 ). In this situation, RAI administration is clearly intended more as an adjuvant treatment or treatment of known disease rather than for thyroid remnant ablation. For activity selection, the precise goal needs to be considered
