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C. Daumerie Departments of Endocrinology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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A. Boschi Departments of Ophthalmology, Université catholique de Louvain, University Hospital St-Luc, Brussels, Belgium

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P. Perros Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK

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exacerbation of GO and use of recombinant human TSH (rhTSH) was suggested in 2005 by Berg et al. [ 1 ], who reported the development of severe GO in a patient with disseminated thyroid cancer treated with recombinant TSH, radioiodine and retinoic acid. Multiple

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000338038
Volume/Issue:
Volume 1: Issue 2
Free access
Steen J. Bonnema Departments of Endocrinology, Odense University Hospital, Odense

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Elisabeth S. Stovgaard Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Søren Fast Departments of Endocrinology, Odense University Hospital, Odense

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Kasper Broedbaek Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Jon T. Andersen Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Allan Weimann Laboratory of Clinical Pharmacology Q7642, Rigshospitalet

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Peter Grupe Departments of Nuclear Medicine, Odense University Hospital, Odense

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Laszlo Hegedüs Departments of Endocrinology, Odense University Hospital, Odense

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Henrik E. Poulsen Laboratory of Clinical Pharmacology Q7642, Rigshospitalet
Department of Clinical Pharmacology, Bispebjerg Hospital
Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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Introduction For many years radioactive iodine ( 131 I) has been used for treatment of nontoxic goiter, hyperthyroidism and thyroid cancer. During the last decade recombinant human TSH (rhTSH) - a very potent stimulator of the thyroid 131 I

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000371883
Volume/Issue:
Volume 4: Issue 1
Free access
Dong Jun Lim Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Korea

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Won Bae Kim Department of Internal Medicine, Asan Medical Center, Korea

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Bo Hyun Kim Department of Internal Medicine, Pusan National University Hospital, Busan, Korea

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Tae Yong Kim Department of Internal Medicine, Asan Medical Center, Korea

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Young Suk Jo Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea

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Ho-Cheol Kang Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea

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Young Joo Park Department of Internal Medicine, Seoul National University Hospital, Korea

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Ka Hee Yi Department of Internal Medicine, Korea Cancer Center Hospital, Korea

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Minho Shong Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea

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In Joo Kim Department of Internal Medicine, Pusan National University Hospital, Busan, Korea

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Do Joon Park Department of Internal Medicine, Seoul National University Hospital, Korea

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Sun Wook Kim Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jaetae Lee Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Korea

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Sung-Soo Koong Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea

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Young Kee Shong Department of Internal Medicine, Asan Medical Center, Korea

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patients and can result in a myriad of deleterious symptoms and impaired quality of life (QoL) [ 2 , 3 ]. According to the recent clinical practice guidelines, recombinant human TSH (rhTSH) can be used as an alternative to THW for remnant ablation or for

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000371512
Volume/Issue:
Volume 4: Issue 1
Free access
Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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pathologic factors, including the ATA class of risk. BiR/InR were defined according to ATA 2015 guidelines as follows: BiR in case of thyroglobulin value on levothyroxine therapy (LT4-Tg) ≥1 ng/mL or Tg peak after recombinant human TSH stimulation (rhTSH

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0052
Volume/Issue:
Volume 12: Issue 6
Open access
Furio Pacini Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Siena, Italy

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Tuttle RM, Brokhin M, Omry G, Martorella AJ, Larson SM, Grewal RK, Fleisher M, Robbins RJ: Recombinant human TSH-assisted radioactive iodine remnant ablation achieves short-term clinical recurrence rates similar to those of traditional thyroid hormone

Article Type:
Editorial
DOI:
https://doi.org/10.1159/000346154
Volume/Issue:
Volume 1: Issue 4
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Birte Nygaard Departments of Endocrinology, Herlev Hospital, Copenhagen

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Jens Bentzen Departments of Oncology, Herlev Hospital, Copenhagen

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Susanne Møller Pedersen Departments of Biochemistry, Odense University Hospital, Odense

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Lars Bastholt Departments of Oncology, Odense University Hospital, Odense

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Aase Handberg Departments of Biochemistry, Aarhus Hospital, Aarhus, Denmark

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Carsten Rytter Departments of Oncology, Aarhus Hospital, Aarhus, Denmark

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Christian Godballe ENT Head and Neck Surgery, Odense University Hospital, Odense

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Jens Faber Departments of Endocrinology, Herlev Hospital, Copenhagen

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therapy [ 4 , 5 ]. Stimulated s-Tg (either endogenous stimulation after withdrawal of L-T4 or L-T3 therapy, or exogenous stimulation after recombinant human TSH injection) and 131 I whole body scan (WBS) are recommended in the initial follow-up after

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000341362
Volume/Issue:
Volume 1: Issue 3
Free access
James Magner Genzyme, a Sanofi company, Cambridge, Mass., USA

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independently, all published in 1988 [ 11 , 12 , 13 ]. The human TSH subunit gene sequences were essential for the preparation of recombinant human TSH, which is made in large bioreactors using Chinese hamster ovary cells, since the posttranslational

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000360534
Volume/Issue:
Volume 3: Issue 2
Free access
Furio Pacini Section of Endocrinology, University of Siena, Siena, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, West German Cancer Centre (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Rossella Elisei Section of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Daria Handkiewicz-Junak Department of Nuclear Medicine and Endocrine Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Markus Luster Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

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Martin Schlumberger Gustave Roussy Cancer Campus and University Paris-Saclay, Villejuif, Cedex, France

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Johannes W Smit Radboud University Medical Center, Nijmegen, Netherlands

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not indicated in PTC < 1 cm (uni- or multifocal)- Abnormal neck ultrasound or high Tg may indicate need for RAI therapy Recombinant human TSH is preferred for TSH stimulation - Indicated for all RAI activities- Approved in all risk groups, but

Article Type:
Other
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-21-0046
Volume/Issue:
Volume 11: Issue 1
Open access
Cláudia C.D. Nakabashi Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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Teresa S. Kasamatsu Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Felipe Crispim Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Claudia A. Yamazaki Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo

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Cléber P. Camacho Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Danielle M. Andreoni Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Rosalia P. Padovani Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Elza S. Ikejiri Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Maria C.O.M. Mamone Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Flávia C. Aldighieri Fleury Medicina e Saúde, São Paulo, Brazil

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Jairo Wagner Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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Jairo T. Hidal Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil

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José G.H. Vieira Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicina e Saúde, São Paulo, Brazil

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Rosa P.M. Biscolla Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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Rui M.B. Maciel Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
Fleury Medicina e Saúde, São Paulo, Brazil

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withdrawal (WD-Tg) or stimulation with recombinant human TSH (rhTSH-Tg) [ 2 , 3 , 4 , 5 ]. Basal Tg measurement during thyroid hormone suppression of TSH (b-Tg) using first-generation Tg (Tg1G) assays with functional sensitivity (FS) of approximately 1.0 ng

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000360077
Volume/Issue:
Volume 3: Issue 1
Free access
Fabián Pitoia Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Erika Abelleira Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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Graciela Cross Division of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina

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. Am J Clin Oncol 2011;35:101-104. 10.1097/COC.0b013e318201a41a 21297429 6 Tuttle RM, Brokhin M, Omry G, Martorella AJ, Larson SM, Grewal RK, Fleisher M, Robbins RJ: Recombinant human TSH-assisted radioactive iodine remnant ablation achieves

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000369135
Volume/Issue:
Volume 3: Issue 4
Free access