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Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University and Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK;

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Mario Vaisman Department of Endocrinology, Faculdade de Medicina, UFRJ, Rio de Janeiro, Brazil;

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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Introduction Subclinical hypothyroidism (SCH) is defined by an elevation of the serum TSH with circulating free thyroid hormone concentrations that are within the reference range [ 1 ]. It is a common issue in clinical practice that

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000335964
Volume/Issue:
Volume 1: Issue 1
Free access
Simon H.S. Pearce Institute of Genetic Medicine, Newcastle University
Royal Victoria Infirmary, Newcastle upon Tyne, UK

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Georg Brabant Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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Leonidas H. Duntas Endocrine Unit, Evgenidion Hospital, University of Athens, Athens, Greece

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Fabio Monzani Department of Clinical and Experimental Medicine, Università di Pisa, Pisa, Italy

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Robin P. Peeters Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Salman Razvi Institute of Genetic Medicine, Newcastle University
Queen Elizabeth Hospital, Gateshead, UK

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Jean-Louis Wemeau Clinique Endocrinologique Marc Linquette, CHU, Lille, France

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Introduction Subclinical hypothyroidism (SCH) is defined as a state of increased serum thyroid-stimulating hormone (TSH) levels, with circulating thyroxine (T 4 ) and tri-iodothyronine (T 3 ) concentrations within the population reference

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000356507
Volume/Issue:
Volume 2: Issue 4
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Nadine Johnson Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Vikash Chatrani Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Anna-Kay Taylor-Christmas Departments of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica

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Eric Choo-Kang Departments of Chemical Pathology, University of the West Indies, Kingston, Jamaica

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Monica Smikle Departments of Microbiology, University of the West Indies, Kingston, Jamaica

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Rosemarie Wright-Pascoe Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Karen Phillips Departments of Medicine, University of the West Indies, Kingston, Jamaica

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Marvin Reid Tropical Metabolism Research Institute, University of the West Indies, Kingston, Jamaica

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Introduction Hypothyroidism is the most common disorder of thyroid function in pregnancy [ 1 ]. Subclinical hypothyroidism (SCH) is defined as serum thyroid-stimulating hormone (TSH) >97.5% and normal free thyroxine (FT 4 ), with or without

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000367654
Volume/Issue:
Volume 3: Issue 4
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Salman Razvi Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Bronia Arnott Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Dawn Teare Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Shaun Hiu Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Nicki O’Brien Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom

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Simon H. Pearce Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

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Introduction Subclinical hypothyroidism (SCH) is a mild form of thyroid failure diagnosed when serum TSH levels are high and circulating thyroid hormones are within the reference range [ 1 , 2 ]. The prevalence of SCH increases with age and

Article Type:
Research Article
Collections:
Hypothyroidism
DOI:
https://doi.org/10.1159/000509228
Volume/Issue:
Volume 10: Issue 4
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Jesper Karmisholt Department of Medical Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
Clinical Institute, Aalborg University, Aalborg, Denmark

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Introduction Subclinical hypothyroidism (SCH) is a frequent condition defined by serum values of thyrotropin (TSH) above and thyroxine (T4) within the population-based reference ranges[ 1 - 3 ]. It may reflect mild thyroid failure with only

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000496827
Volume/Issue:
Volume 8: Issue 3
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Roberto Negro Division of Endocrinology, “V. Fazzi” Hospital, Lecce, Italy

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Roberto Attanasio Endocrinology Service, Galeazzi Institute IRCCS, Milan, Italy

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Enrico Papini Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Rinaldo Guglielmi Department of Endocrinology, Regina Apostolorum Hospital, Albano Laziale, Italy

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Franco Grimaldi Endocrinology and Metabolic Disease Unit, Azienda Ospedaliero-Universitaria “S. Maria della Misericordia”, Udine, Italy

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Vincenzo Toscano Endocrinology, Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, Roma, Italy

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Dan Alexandru  Niculescu Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Diana Loreta  Paun Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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Catalina Poiana Department of Endocrinology, Carol Davila University of Medicine of Pharmacy, Bucharest, Romania

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in childbearing age, and the evidence of adverse events especially associated with overt thyroid disease. Among thyroid diseases, thyroid autoimmunity (TAI) and subclinical hypothyroidism (SCH) are by far the most frequent, involving at least 10% of

Article Type:
Case Report
DOI:
https://doi.org/10.1159/000490944
Volume/Issue:
Volume 7: Issue 6
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John Lazarus Thyroid Research Group, Institute of Molecular Medicine, Cardiff University, University Hospital of Wales, Cardiff

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Rosalind S. Brown Clinical Trials Research Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Mass., USA

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Chantal Daumerie Endocrinologie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Krakow, Poland

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter, UK

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Introduction Subclinical hypothyroidism (SCH) in pregnancy is defined by a serum thyroid-stimulating hormone (TSH) concentration higher than the upper limit of the pregnancy-related reference range associated with a normal serum thyroxine [T 4

Article Type:
Guideline
DOI:
https://doi.org/10.1159/000362597
Volume/Issue:
Volume 3: Issue 2
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Diogo Mendes Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal

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Carlos Alves Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal

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Nuno Silverio Merck S.A., Algés, Portugal

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Francisco Batel Marques Center for Health Technology Assessment and Drug Research, Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
Laboratory of Social Pharmacy and Public Health, School of Pharmacy, University of Coimbra, Coimbra, Portugal

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a decreased level of serum free thyroxin (fT 4 ) as compared to the reference ranges in the general population. Subclinical hypothyroidism is defined as an elevated serum TSH level in combination with a normal serum fT 4 level [ 1 , 2 ]. The

Article Type:
Review Article
DOI:
https://doi.org/10.1159/000499751
Volume/Issue:
Volume 8: Issue 3
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Horea Ioan Ursu C.I. Parhon National Institute of Endocrinology, and Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Dear Sir, In my view, an additional treatment indication for subclinical hypothyroidism (table 2 in Pearce et al. [ 1 ]) might be represented by patients with melanomas, the most aggressive malignancy arising from the skin. This suggestion

Article Type:
Letter
DOI:
https://doi.org/10.1159/000339817
Volume/Issue:
Volume 1: Issue 3
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Érique José F. Peixoto de Miranda Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Márcio Sommer Bittencourt Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Itamar S. Santos Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Paulo A. Lotufo Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Isabela M. Benseñor Centro de Pesquisa Clínica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil

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Introduction The link between subclinical hypothyroidism (SCH), which is defined as high serum thyroid-stimulating hormone (TSH) concomitant with normal serum free thyroxine levels (fT 4 ) [ 1 ], and cardiovascular disease remains

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000448683
Volume/Issue:
Volume 5: Issue 4
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