Sofia Macedo
Sofia Macedo
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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Ana Pestana
Ana Pestana
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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Liliana Santos
Liliana Santos
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
North Lisbon University Hospital Center, Lisbon, Portugal
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Faculty of Medicine, University of Porto, Porto, Portugal
North Lisbon University Hospital Center, Lisbon, Portugal
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Celestino Neves
Celestino Neves
Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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University Hospital Center of São João, Porto, Portugal
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Susana Guimarães
Susana Guimarães
Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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University Hospital Center of São João, Porto, Portugal
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Amaro Duarte-Neto
Amaro Duarte-Neto
Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
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Marisa Dolhnikoff
Marisa Dolhnikoff
Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
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Paulo Saldiva
Paulo Saldiva
Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil
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Georgina Alves
Georgina Alves
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
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Rute Oliveira
Rute Oliveira
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
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Didier Cabanes
Didier Cabanes
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
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Fátima Carneiro
Fátima Carneiro
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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Manuel Sobrinho-Simões
Manuel Sobrinho-Simões
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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Faculty of Medicine, University of Porto, Porto, Portugal
University Hospital Center of São João, Porto, Portugal
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Paula Soares
Paula Soares
Institute for Research & Innovation in Health, University of Porto, Porto, Portugal
Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
Faculty of Medicine, University of Porto, Porto, Portugal
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, reinforcing the putative (direct or indirect) role of SARS-Cov-2 on thyroid hormones’ regulation ( 16 ). In order for SARS-CoV-2 to infect the host cell, other key players besides ACE-2 are required. Furin and the transmembrane protease serine 2 (TMPRSS2
Ilaria Muller
Ilaria Muller
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Anita Daturi
Anita Daturi
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Matteo Varallo
Matteo Varallo
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Tiziana E Re
Tiziana E Re
Internal Medicine - High Intensity of Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Davide Dazzi
Davide Dazzi
Casa di Cura Val Parma SRL, Langhirano (Parmigiano: Langhiràn), Italy
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Sara Maioli
Sara Maioli
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Erica Crivicich
Erica Crivicich
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Francesco Di Marco
Francesco Di Marco
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Virgilio Longari
Virgilio Longari
Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Beatrice Dazzi
Beatrice Dazzi
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Massimo Castellani
Massimo Castellani
Nuclear Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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Giovanna Mantovani
Giovanna Mantovani
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Maura Arosio
Maura Arosio
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Italy
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Mario Salvi
Mario Salvi
Endocrinology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
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-converting enzyme 2 (ACE2) is the entry receptor used by SARS-CoV-2 to infect the host cell ( 3 , 4 ). Both ACE2 and the transmembrane protease serine 2 (TMPRSS2), necessary for SARS-CoV-2 internalisation and activation, are highly expressed in the thyroid tissue
Sepehr Torabinejad
Sepehr Torabinejad
Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy
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Caterina Miro
Caterina Miro
Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy
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Biagio Barone
Biagio Barone
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II
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Ciro Imbimbo
Ciro Imbimbo
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II
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Felice Crocetto
Felice Crocetto
Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II
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Monica Dentice
Monica Dentice
Department of Clinical Medicine and Surgery, University of Naples ’Federico II’, Naples, Italy
CEINGE – Biotecnologie Avanzate Scarl, Naples, Italy
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CEINGE – Biotecnologie Avanzate Scarl, Naples, Italy
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inhibitor 1B ( CDKN1B ) genes, promoter hypermethylation (in retinoblastoma ( RB1 ), PTEN and cadherin 1 genes), and also the fusion of the androgen-induced transmembrane gene serine 2 protease gene ( TMPRSS2 ) with members of the erythroblast
Fabyan Esberard de Lima Beltrão
Fabyan Esberard de Lima Beltrão
Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
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University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
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Daniele Carvalhal de Almeida Beltrão
Daniele Carvalhal de Almeida Beltrão
University Center of João Pessoa – UNIPE, João Pessoa, PB, Brazil
Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Giulia Carvalhal
Giulia Carvalhal
Center for Biological and Health Sciences, Federal University of Campina Grande, Campina Grande, Paraíba, Brazil
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Fabyanna Lethicia de Lima Beltrão
Fabyanna Lethicia de Lima Beltrão
Post-Graduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Brazil
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Jocyel de Brito Oliveira
Jocyel de Brito Oliveira
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Hatilla dos Santos Silva
Hatilla dos Santos Silva
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Helena Mariana Pitangueira Teixeira
Helena Mariana Pitangueira Teixeira
Bioregulation Department, Health and Science Institut, Federal University of Bahia, Salvador, Bahia, Brazil
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Juliana Lopes Rodrigues
Juliana Lopes Rodrigues
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Camila Alexandrina Viana de Figueiredo
Camila Alexandrina Viana de Figueiredo
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Ryan dos Santos Costa
Ryan dos Santos Costa
Laboratory of Immunopharmacology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Brazil
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Fabio Hecht
Fabio Hecht
The Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
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Giciane Carvalho Vieira
Giciane Carvalho Vieira
Post-Graduation Program in Cognitive Neuroscience and Behavior, Psychology Department of the Center of Human Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Maria da Conceição Rodrigues Gonçalves
Maria da Conceição Rodrigues Gonçalves
Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Antonio C. Bianco
Antonio C. Bianco
Section of Endocrinology and Metabolism, Division of the Biological Sciences, University of Chicago, Chicago, Illinois, USA
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Helton Estrela Ramos
Helton Estrela Ramos
Post-Graduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Brazil
Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil
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Postgraduate Program in Interactive Processes of Organs and Systems, Health & Science Institute, Federal University of Bahia, Salvador, BA, Brazil
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A et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor . Cell 2020 181 271 – 280.e8 . ( https://doi.org/10.1016/J.CELL.2020.02.052 ) 2 Zhu N Zhang D Wang W Li X Yang B Song J
