Bernadette L Dekker
Bernadette L Dekker
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Anouk N A van der Horst-Schrivers
Anouk N A van der Horst-Schrivers
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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Adrienne H Brouwers
Adrienne H Brouwers
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Christopher M Shuford
Christopher M Shuford
Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North California, USA
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Ido P Kema
Ido P Kema
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Anneke C Muller Kobold
Anneke C Muller Kobold
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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Thera P Links
Thera P Links
Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
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-tandem mass spectrometry (LC-MS/MS), which digests Tg into peptides for analytical measurement, disrupting the interfering TgAbs ( 8 ). However, Tg-LC-MS/MS assays studied to date are hampered by a lack of sensitivity compared to Tg immunoassays ( 1 , 2 , 9
Eijun Nishihara
Eijun Nishihara
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Yoshitaka Hobo
Yoshitaka Hobo
ASKA Pharmamedical Co., Ltd. Fujisawa, Japan
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Akira Miyauchi
Akira Miyauchi
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Yasuhiro Ito
Yasuhiro Ito
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Miyoko Higuchi
Miyoko Higuchi
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Mitsuyoshi Hirokawa
Mitsuyoshi Hirokawa
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Mitsuru Ito
Mitsuru Ito
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Shuji Fukata
Shuji Fukata
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Mitsushige Nishikawa
Mitsushige Nishikawa
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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Takashi Akamizu
Takashi Akamizu
Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan
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immunocapture of Tg-specific peptides ( 4 ). Among various Tg peptides following cleavage at lysine or arginine with trypsin, two specific peptides, VIFDANAPVAVR and FSPDDSAGASALLR, have been reported to be reliable targets for Tg-LC-MS/MS ( 5 , 6 ). Although
