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mice were also studied. Free Thyroxine Levels and Thyrotropin Receptor Antibodies Serum fT4 and TSHR-binding inhibiting autoantibodies (TBII) levels were measured with Immulite 2000 XPi (Siemens, Erlangen, Germany) according to the
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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What Is Known about This Topic? The prevalence of thyrotoxicosis in patients with thyroid cancer is unknown. In view of the sparse reports, it is most likely very low. Thyrotropin receptor antibodies are seldom measured or found in
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Introduction Autoantibodies against the thyrotropin receptor (TSH-R-Ab) play an important role in the pathogenesis of autoimmune thyroid diseases [ 1 - 5 ]. These functional antibodies demonstrate different effects on the TSH-R and can either
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-9972 2 Diana T , Olivo PD , Kahaly GJ . Thyrotropin Receptor Blocking Antibodies . Horm Metab Res . 2018 Dec ; 50 ( 12 ): 853 – 62 . 10.1055/a-0723-9023 30286485 0018-5043 3 Kanike N , Davis A , Shekhawat PS
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Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz, Germany
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mechanisms. Although the levels of thyrotropin receptor autoantibody (TSH-R-Ab), which is the specific biomarker of GD [ 11 , 12 ], decline during ATD therapy, ATDs primarily inhibit thyroid hormone biosynthesis only, and whether they directly target thyroid
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vedolizumab, oral budesonide and mycophenolic acid. In April 2020, the patient presented a mild COVID-19 and received hydroxychloroquine. Concomitantly, he developed transient hypothyroidism with negative thyroid peroxidase antibody (TPOAb) and thyrotropin-receptor
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to promiscuous activation of the thyrotropin receptor by chorionic gonadotropin [ 21 ]. Follicle-stimulating hormone (FSH), luteinizing hormone, chorionic gonadotropin and TSH constitute the glycoprotein hormones made of a common α-subunit and
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features of Graves’ disease in the first trimester of pregnancy may occur due to stimulation of the thyroid both by human chorionic gonadotropin and thyrotropin receptor-stimulating antibodies [ 3 , 4 , 5 ]. The markedly increased thyroid hormone
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Introduction TSH-Receptor, Graves’ Disease and Graves’ Orbitopathy The thyrotropin receptor or thyroid-stimulating hormone (TSH) receptor (TSHR) is mainly expressed in follicular epithelial cells of the thyroid gland [ 1 ]. TSHR activation
