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]. Treatment of hypothyroidism is today predominantly with L-T4: its long half-life of 1 week is advantageous allowing one daily dose and it generates stable T3 levels by conversion of T4 into T3 in peripheral tissues. In contrast, the half-life of T3 is short
FMTS, Faculté de Médecine, Université de Strasbourg, Strasbourg
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Inserm U1037, Université Paul Sabatier, Toulouse, France
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, few studies have compared the results of the 3 available treatment options: medical treatment with synthetic antithyroid drugs (ATDs), treatment with iodine 131 ( 131 I), or surgery. Medical treatment blocks hormone synthesis and the release of thyroid
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and is currently under investigation as a possible treatment option for MCT8-deficient patients [ 8 , 15 ]. The use of chemical and pharmacological chaperones could be another treatment option for a fraction of MCT8-deficient patients. The chemical
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indicator of hypoparathyroidism [ 11 , 12 ]. In the vast majority of cases, hypoparathyroidism is transient, lasting only a few days after surgery, with a temporary substitute treatment need. However, the condition is considered permanent when low PTH
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Introduction Thyroid dysfunction (TD) is a common side effect of many treatments acting with different mechanisms, including but not limited to interferon alpha [ 1 ], interleukin-2 [ 2 ], thalidomide [ 3 ], amiodarone [ 4 ], radiation therapy
Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
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consequences of targeted immune responses. These immune responses are thought to be intimately related to those occurring in the thyroid. Despite the potential seriousness of TAO, effective treatment of the disease represents an important, unmet need. This void
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What Is Known about This Topic? True malabsorption is a cause of refractory hypothyroidism. Treatment with intramuscular levothyroxine (LT4) is an alternative for the treatment of these patients. What Does This Case Report Add
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Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
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Department of Medicine, College of Medicine and King Saud Medical City, King Saud University, Riyadh, Saudi Arabia
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Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
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). Thyroid hormone replacement is currently the primary treatment method for hypothyroidism ( 6 ). According to patient feedback, levothyroxine (LT 4 ) is a synthetic replacement for thyroid tests. The recommended dose for adults is 1.6 µg/kg, adjusted every
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are in the end unhappy with the treatment outcome [ 2 ]. After medical treatment, many patients require some kind of rehabilitative surgery (orbital decompression, squint surgery, eyelid surgery) to correct residual manifestations. The reasons for this
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Introduction The main objective of the initial treatment of differentiated thyroid cancer (DTC) is to cure the patients and to reduce the risk of persistent/recurrent disease ( 1 ). However, in several patients, persistence or recurrence of
