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Earn H. Gan Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom

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Anna L. Mitchell Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom

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Ruth Plummer Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom

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Simon Pearce Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom

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Petros Perros Institute of Genetic Medicine, International Centre for Life, Newcastle upon Tyne, United Kingdom

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the first 12 weeks following anti-CTLA-4 therapy. In this case, Graves disease developed after 8 years of tremelimumab therapy for metastatic melanoma. Antithyroid drug therapy was safe and effective alongside anti-CTLA-4 therapy without

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Pauline Campredon Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France

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Philippe Imbert Ophthalmologist, Clinique du Parc, Toulouse, France
Multidisciplinary Thyroid Eye Consultation, Department of Endocrinology, Larrey University Hospital, Toulouse, France

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Céline Mouly Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France

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Solange Grunenwald Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France

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Julien Mazières Department of Pneumology, Larrey University Hospital, Toulouse, France

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Philippe Caron Department of Endocrinology and Metabolic Diseases, Larrey University Hospital, Toulouse, France

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. Anti-cytotoxic T-lymphocytic-associated antigen-4 antibodies (ipilimumab, tremelimumab) preferentially exhibited pituitary toxicity with hypophysitis as the primary consequence. The most frequent endocrine disorders related to anti-PD-1 monoclonal

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Alessandro Brancatella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Nicola Viola Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Sandra Brogioni Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Lucia Montanelli Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Chiara Sardella Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Paolo Vitti Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Claudio Marcocci Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Isabella Lupi Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Francesco Latrofa Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Pisa, Pisa, Italy

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Treatment of Ipilimumab Induced Graves ’ Disease in a Patient with Metastatic Melanoma. 2016 ;2016(Table 1):1–5. 12 Gan EH , Mitchell AL , Plummer R , Pearce S , Perros P . Tremelimumab-Induced Graves Hyperthyroidism. 2017 ;167

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