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]. RET (rearranged during transfection) proto-oncogene mutations play a key role in the pathogenesis of the disease. RET encodes a single-pass transmembrane protein receptor that belongs to receptor tyrosine kinase family. Activating germline mutations
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). What Does This Case Report Add? This case illustrates a patient with locally advanced DTC treated with tyrosine kinase inhibitor (TKI) therapy, which markedly reduced tumour volume and allowed subsequent successful surgical resection without
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Center for Head and Neck Surgery, Kusatsu General Hospital, Kusatsu, Japan
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strategies are required to improve the prognosis. Lenvatinib is an oral tyrosine kinase inhibitor targeting VEGFR1–3, FGFR1–4, RET, KIT, and PDGFRβ [ 6 - 8 ]. It was associated with a marked improvement in progression-free survival in patients with
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What Is Known About This Topic? Several side effects have been described with the use of tyrosine kinase inhibitors like sorafenib. Nonetheless, only 9 cases of pancreatitis related to sorafenib treatment have been described, all of them
Institute of Pathology, University Hospital Halle (Saale), Halle (Saale), Germany
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Introduction The neurotrophic tyrosine kinase receptor (NTRK) inhibitors, larotrectinib and entrectinib, were approved by the United States Food & Drug Administration (FDA) for the treatment of NTRK fusion-positive solid tumors that are
Department of Endocrinology and Nephrology, Division of Nephrology, University Clinic Leipzig, Leipzig, Germany
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treatment with lenvatinib and no concerning co-medications were reported. What Does This Case Report Add? We report two severe AEs of anti-VEGF tyrosine kinase inhibitor treatment which were not reported in the phase III trials. Our case
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Faculty of Medical Sciences of Lisbon, Lisbon, Portugal
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a part in the pathogenesis of thyroid cancer and these represent potential treatment targets [ 6 ]. As such, several multitargeted tyrosine kinase inhibitors (TKIs) have been investigated for the treatment of RAI-refractory thyroid cancer with the
Internal Medicine, Erasmus MC, University Medical Center Rotterdam
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Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland
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Internal Medicine, Erasmus MC, University Medical Center Rotterdam
Rotterdam Eye Hospital, Rotterdam, The Netherlands
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fibroblast functions In recent years numerous novel, targeted therapies have been introduced in clinical practice, like the biologicals and tyrosine kinase inhibitors (TKIs). Therapeutic strategies that target specific cytokines, growth factors or
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Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
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Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
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biological characteristics of this tumor, which has a relatively low growth rate and is poorly symptomatic. Nevertheless, patients experience a relevant weight decrease when treatment with a tyrosine kinase inhibitor (TKI) is started, such as lenvatinib
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Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
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, including chemotherapy and external beam radiation therapy, remains limited in these challenging settings. In recent years, tyrosine kinase inhibitors (TKIs) such as sorafenib and lenvatinib have highlighted new therapeutic options for the treatment of