Laura Agate
Laura Agate
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Francesca Bianchi
Francesca Bianchi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Federica Brozzi
Federica Brozzi
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Pierina Santini
Pierina Santini
Unit of Endocrine and Oncological Nuclear Medicine Therapy, Diagnostic and Imaging Department, University of Pisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Valeria Bottici
Valeria Bottici
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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David Viola
David Viola
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Paolo Vitti
Paolo Vitti
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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papillary thyroid carcinoma (PTC); (b) the diagnostic purpose due to the possibility to perform a post-RRA whole-body scan (ptWBS) to identify additional sites of disease not identified before the RRA [ 2 - 4 ]; and (c) the facilitator purpose because the
Aamna Hassan
Aamna Hassan
Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
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Saima Riaz
Saima Riaz
Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
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Humayun Bashir
Humayun Bashir
Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
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M. Khalid Nawaz
M. Khalid Nawaz
Departments of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
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Raza Hussain
Raza Hussain
Departments of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
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-FDG PET/CT scans performed over 5 years in DTC patients with stimulated Tg levels >10 ng/ml or positive anti-Tg antibody (TgAb) and a negative 131 I NaI whole-body scan (WBS). Patients were classified based on their TNM stage and ATA risk categorization
Abdul Rehman Syed
Abdul Rehman Syed
University of Calgary, Calgary, Alberta, Canada
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Aakash Gorana
Aakash Gorana
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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Erik Nohr
Erik Nohr
Alberta Precision Laboratories, Molecular Pathology Program, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Xiaoli-Kat Yuan
Xiaoli-Kat Yuan
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Parthiv Amin MASc
Parthiv Amin MASc
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary Alberta, Canada
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Sana Ghaznavi
Sana Ghaznavi
Arnie Charbonneau Cancer Institute, Department of Medicine, Section of Endocrinology, University of Calgary, Calgary, Alberta, Canada
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Debbie Lamb
Debbie Lamb
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada
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John McIntyre
John McIntyre
Precision Oncology Hub Laboratory, Tom Baker Cancer Centre, Calgary, Alberta, Canada
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Markus Eszlinger
Markus Eszlinger
Department of Oncology, Cumming School of Medicine, and Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada
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Ralf Paschke
Ralf Paschke
Departments of Medicine, Section of Endocrinology, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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of recurrence. In January 2018, he received 150 mCi (5550 MBq) of 131 I for thyroid ablation with subsequent post- 131 I therapy whole-body scan(WBS) indicating RAI accumulation in the thyroid bed and a low-grade RAI accumulation within the lungs
Marie Alix Balay
Marie Alix Balay
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Patrick Aidan
Patrick Aidan
American Hospital of Paris, Neuilly sur Seine, France
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Marie Helene Schlageter
Marie Helene Schlageter
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Odette Georges
Odette Georges
American Hospital of Paris, Neuilly sur Seine, France
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Taly Meas
Taly Meas
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Maroun Bechara
Maroun Bechara
American Hospital of Paris, Neuilly sur Seine, France
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Marie Elisabeth Toubert
Marie Elisabeth Toubert
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Isabelle Faugeron
Isabelle Faugeron
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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Herve Monpeyssen
Herve Monpeyssen
American Hospital of Paris, Neuilly sur Seine, France
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Cécile N. Chougnet
Cécile N. Chougnet
Hôpital Saint Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
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-Tg antibodies (anti-Tg Ab). Stimulated Tg was measured either on the day of RAI administration in the case of levothyroxine withdrawal, or on the peak 5th or 6th day after rhTSH stimulation. A posttherapeutic whole body scan combined with SPECT CT (single photon
Rosália P. Padovani
Rosália P. Padovani
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
Department of Nuclear Medicine, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
Department of Nuclear Medicine, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil
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Rui M.B. Maciel
Rui M.B. Maciel
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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Teresa S. Kasamatsu
Teresa S. Kasamatsu
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
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Beatriz C.G. Freitas
Beatriz C.G. Freitas
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
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Marilia M.S. Marone
Marilia M.S. Marone
Department of Nuclear Medicine, Irmandade Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil
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Cleber P. Camacho
Cleber P. Camacho
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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Rosa Paula M. Biscolla
Rosa Paula M. Biscolla
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil
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24U and sU), all patients were instructed to follow an RID (table 1 ) and undergo thyroid hormone withdrawal before having 131 I treatment or a whole-body scan. For the RID, the 306 patients were divided into 2 groups of 153 patients; the first
Sara Donato
Sara Donato
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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Helder Simões
Helder Simões
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal
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, radioactive iodine; WBS, whole-body scan. She received 100 mCi of radioactive iodine (RAI) with recombinant TSH. The stimulated Tg was 7.5 ng/mL and the post-RAI whole-body scan showed a moderate cervical residual uptake (as presented in Fig. 1
Pedro Weslley Rosario
Pedro Weslley Rosario
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Gabriela Franco Mourão
Gabriela Franco Mourão
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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Maria Regina Calsolari
Maria Regina Calsolari
Santa Casa de Belo Horizonte, Belo Horizonte, Brazil
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as several examinations per patient [ 4 ], sometimes followed by FNA, resulting in high costs. In patients with macroscopically complete tumor resection who receive RAI, persistent locoregional disease is more commonly detected by posttherapy whole-body
Beng Khiong Yap
Beng Khiong Yap
The Christie NHS Foundation Trust
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Jarrod Homer
Jarrod Homer
Central Manchester NHS Foundation Trust
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Neil Parrott
Neil Parrott
Central Manchester NHS Foundation Trust
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Sean Loughran
Sean Loughran
Central Manchester NHS Foundation Trust
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Brian Murby
Brian Murby
The Christie NHS Foundation Trust
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Ric Swindell
Ric Swindell
The Christie NHS Foundation Trust
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Ashu Gandhi
Ashu Gandhi
University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
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were started on T 4 4 days after RAI. Thyroid-stimulating hormone (TSH)-stimulated 131 I diagnostic whole-body scans (DxWBS) and measurement of Tg and Tg antibody (Tg-Ab) levels either following thyroid hormone withdrawal or recombinant TSH
Carolina C.P.S. Janovsky
Carolina C.P.S. Janovsky
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Rui M.B. Maciel
Rui M.B. Maciel
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Cleber P. Camacho
Cleber P. Camacho
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Rosalia P. Padovani
Rosalia P. Padovani
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Claudia C. Nakabashi
Claudia C. Nakabashi
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Ji H. Yang
Ji H. Yang
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Eduardo Z. Malouf
Eduardo Z. Malouf
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Elza S. Ikejiri
Elza S. Ikejiri
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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M. Conceição O.C. Mamone
M. Conceição O.C. Mamone
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Jairo Wagner
Jairo Wagner
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Danielle M. Andreoni
Danielle M. Andreoni
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Rosa Paula M. Biscolla
Rosa Paula M. Biscolla
Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
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measurements (Tg temporal trend), stimulated Tg levels or whole-body scan (WBS) uptake. Subjects and Methods Study Design We performed a prospective study at a single Brazilian thyroid disease center to evaluate the outcomes of low-risk thyroid
Mathieu Spaas
Mathieu Spaas
Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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Brigitte Decallonne
Brigitte Decallonne
Department of Endocrinology and Internal Medicine, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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Annouschka Laenen
Annouschka Laenen
Leuven Biostatistics and Statistical Bioinformatics Centre, Leuven, Belgium
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Jaak Billen
Jaak Billen
Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium
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Sandra Nuyts
Sandra Nuyts
Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium
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Objective: The prognostic value of stimulated thyroglobulin (sTg) and Tg-related parameters prior to and immediately after radioactive iodine (RAI) administration was assessed in a cohort of patients presenting with differentiated thyroid cancer (DTC) as a predictor of recurrent or progressive structural disease. Methods: Clinical records of 180 DTC patients were retrospectively reviewed, and serum TSH, Tg, and Tg antibodies were recorded just before RAI administration (pre-) and at the time of whole body scanning (post-). Based on the results of initial staging and RAI scintigraphy, patients were divided into two groups: those who were considered to be structurally disease-free after thyroidectomy and RAI (group 1) and those who were not (group 2). Univariate analyses were performed for pre-Tg, ratioTg (post-Tg/pre-Tg), and other clinical and pathological markers for long-term outcome, as well as separate bivariate analyses focusing on pre-Tg to correct for possible confounders. Different pre-Tg cut-off values for predicting structural disease recurrence were assessed in a subgroup of patients in group 1 prepared with thyroid hormone withdrawal. Results: In group 1, (n = 166) male gender, higher T-stage and both Tg-related parameters proved to be significant risk factors for structural disease relapse. Of all candidate variables, only higher T-stage served to predict progressive structural disease in group 2 (n = 14). Subgroup analysis showed a negative predictive value of 91.67% for pre-Tg < 10 µg/L. Conclusion: The sTg value at the time of RAI administration may be helpful in predicting structural disease recurrence in patients with DTC.
