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hypothyroidism or occasionally secondary to iatrogenic factors (e.g. immune checkpoint inhibitors). Although antidepressant and antipsychotic medications have been reported to influence TH levels by a variety of mechanisms ( 4 ), to our knowledge there are no
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. There are, however, newer retrospective data that raises concerns with one study showing increased risk of heart failure and possible stroke and another with increased risk of anti-psychotic prescription ( 17 , 18 ). It is not a surprise that
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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treatment and/or had potentially fatigue-determining comorbidities (anaemia, renal or liver failure, other malignancies, depressive syndrome, etc.) and/or were on treatment with drugs potentially leading to fatigue (e.g. antipsychotics). l -thyroxine dosage