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Simona Censi, Jacopo Manso, Teresa Benvenuti, Ilaria Piva, Maurizio Iacobone, Alberto Mondin, Francesca Torresan, Daniela Basso, Gino Crivellari, Stefania Zovato, and Caterina Mian

necessary if there is lateral lymph node compartment involvement ( 2 ). MTC follow-up is then based on a periodical neck ultrasound (US) and biochemical follow-up, based primarily on calcitonin (Ct) and carcinoembryonic antigen (CEA) measurement. Ct is

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Stéphane Bardet, Renaud Ciappuccini, Livia Lamartina, and Sophie Leboulleux

selpercatinib. Introduction Serum tumour markers are important tools in the management of patients with medullary thyroid carcinoma (MTC) ( 1 ). Serum calcitonin (CT) and carcinoembryonic antigen (CEA) are produced by neoplastic C-cells, and their

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Laura Fugazzola

Calcitonin, the Marker of Medullary Thyroid Cancer Medullary thyroid cancer (MTC) can be a very aggressive tumor. Significant differences in survival have been reported according to the stage of the tumor at the time of diagnosis, the survival

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Else Marie Opsahl, Lars Andreas Akslen, Ellen Schlichting, Turid Aas, Katrin Brauckhoff, Anne Irene Hagen, Alf Frimann Rosenlund, Eva Sigstad, Krystyna K. Grøholt, Lars H. Jørgensen, and Trine Bjøro

disease in the lateral neck [ 3 , 14 ]. High-resolution ultrasound is important in disease staging, enabling the detection of even very small metastatic lymph nodes but not micrometastases. Calcitonin is a good tumor marker in MTC. As a rule, it is

Free access

Catarina Silvestre, Joaquim Sampaio Matias, Helena Proença, and Maria João Bugalho

Introduction Calcitonin (Ctn) is a 32-amino acid polypeptide secreted by the parafollicular cells of the thyroid, called “C” cells. With a known important role in regulating blood calcium in fish and rodents, the role of Ctn in human calcium

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Fabio Maino, Cristina Dalmiglio, Nicoletta Benenati, Michele Campanile, Tania Pilli, Raffaella Forleo, Lucia Brilli, Cristina Ciuoli, Silvia Cantara, Marco Capezzone, Alessandra Cartocci, Furio Pacini, and Maria Grazia Castagna

Introduction Calcitonin (CT), a 32-amino acid calcium-lowering peptide secreted by the C-cells (parafollicular cells) of the thyroid, is used as a marker for the diagnosis and the follow-up of medullary thyroid cancer (MTC) [ 1 ]. In patients

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Cléber P. Camacho, Susan C. Lindsey, Teresa S. Kasamatsu, Alberto L. Machado, João Roberto M. Martins, Rosa Paula M. Biscolla, Magnus R. Dias da Silva, José Gilberto H. Vieira, and Rui M.B. Maciel

Introduction Serum calcitonin (sCT) is a useful biomarker for medullary thyroid cancer (MTC) and is employed for its diagnosis and follow-up monitoring [ 1 ]. In addition, some guidelines advocate sCT measurements for the differential

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Isabelle Clinckspoor, Anne-Catherine Gérard, Jacqueline Van Sande, Marie-Christine Many, Lieve Verlinden, Roger Bouillon, Geert Carmeliet, Chantal Mathieu, Annemieke Verstuyf, and Brigitte Decallonne

antithyroid antibodies and abnormal thyroid function in humans [ 19 , 20 ], and to modulate autoimmune hyperthyroidism in mice [ 21 ]. Apart from inhibiting osteoclast-mediated bone resorption and increasing renal calcium and phosphate excretion, calcitonin

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Abbas Al-Kurd, David J. Gross, David Zangen, Karine Atlan, Haggi Mazeh, and Simona Grozinsky-Glasberg

should be revised to recommend calcitonin screening and prophylactic thyroidectomy at an earlier age in such patients. Due to the rarity of these patients, cumulative literature on the topic is essential, and, therefore, reports such as the present one

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Renata Alencar, Daniel Barretto Kendler, Fernanda Andrade, Carla Nava, Daniel Bulzico, Cencita Cordeiro de Noronha Pessoa, Rossana Corbo, and Fernanda Vaisman

monitored after for serum levels of calcitonin and carcinoembryonic antigen (CEA) usually twice or three times a year. After 2015, CA19-9 serum levels were also routinely measured in these patients and were collected usually at each semester. Imaging tests