Simona Censi
Simona Censi
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Jacopo Manso
Jacopo Manso
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Teresa Benvenuti
Teresa Benvenuti
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Ilaria Piva
Ilaria Piva
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Maurizio Iacobone
Maurizio Iacobone
Endocrine Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
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Alberto Mondin
Alberto Mondin
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Francesca Torresan
Francesca Torresan
Endocrine Surgery Unit, Department of Surgical, Oncological and Gastroenterological Sciences (DiSCOG), University of Padua, Padua, Italy
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Daniela Basso
Daniela Basso
Laboratory Medicine, Department of Medicine (DIMED), University of Padua, Padua, Italy
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Gino Crivellari
Gino Crivellari
Hereditary Tumor Unit, Istituto Oncologico Veneto, IOV - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
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Stefania Zovato
Stefania Zovato
Hereditary Tumor Unit, Istituto Oncologico Veneto, IOV - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padova, Italy
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Caterina Mian
Caterina Mian
Endocrinology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy
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necessary if there is lateral lymph node compartment involvement ( 2 ). MTC follow-up is then based on a periodical neck ultrasound (US) and biochemical follow-up, based primarily on calcitonin (Ct) and carcinoembryonic antigen (CEA) measurement. Ct is
Stéphane Bardet
Stéphane Bardet
Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France
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Renaud Ciappuccini
Renaud Ciappuccini
Department of Nuclear Medicine and Thyroid Unit, Centre François Baclesse, Caen, France
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Livia Lamartina
Livia Lamartina
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy, Villejuif, France
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selpercatinib. Introduction Serum tumour markers are important tools in the management of patients with medullary thyroid carcinoma (MTC) ( 1 ). Serum calcitonin (CT) and carcinoembryonic antigen (CEA) are produced by neoplastic C-cells, and their
Zhaoqi Zhang
Zhaoqi Zhang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Department of Nuclear Medicine, The Fourth hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Josef Yu
Josef Yu
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Eva Rainer
Eva Rainer
Department of Biomedical Imaging and Image-guided Therapy, Division of General and Pediatric Radiology, Medical University of Vienna, Vienna, Austria
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Lindsay Hargitai
Lindsay Hargitai
Department of General Surgery, Medical University of Vienna, Vienna, Austria
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Zewen Jiang
Zewen Jiang
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Georgios Karanikas
Georgios Karanikas
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Tatjana Traub-Weidinger
Tatjana Traub-Weidinger
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Richard Crevenna
Richard Crevenna
Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
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Marcus Hacker
Marcus Hacker
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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Shuren Li
Shuren Li
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria
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, early diagnosis of the primary tumor and metastases is essential for outcomes. Basal calcitonin (bCt) and carcinoembryonic antigen (CEA) can be used for diagnosis and follow-up of MTC. In case of increased bCt levels, a calcium stimulation test may be
Laura Fugazzola
Laura Fugazzola
Department of Clinical Sciences and Community Health, University of Milan and Endocrine Unit, Fondazione IRCCS Ca' Granda, Milan, Italy
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Calcitonin, the Marker of Medullary Thyroid Cancer Medullary thyroid cancer (MTC) can be a very aggressive tumor. Significant differences in survival have been reported according to the stage of the tumor at the time of diagnosis, the survival
Else Marie Opsahl
Else Marie Opsahl
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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Lars Andreas Akslen
Lars Andreas Akslen
Section for Pathology, Department of Clinical Medicine, Centre for Cancer Biomarkers CCBIO, University of Bergen, Bergen, Norway
Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
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Department of Pathology, Haukeland University Hospital Bergen, Bergen, Norway
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Ellen Schlichting
Ellen Schlichting
Section of Breast- and Endocrine Surgery, Department of Oncology, Oslo University Hospital, Oslo, Norway
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Turid Aas
Turid Aas
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
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Katrin Brauckhoff
Katrin Brauckhoff
Department of Breast- and Endocrine Surgery, Haukeland University Hospital, Bergen, Norway
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Anne Irene Hagen
Anne Irene Hagen
Department of Breast- and Endocrine Surgery, St. Olavs University Hospital, Trondheim, Norway
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Alf Frimann Rosenlund
Alf Frimann Rosenlund
Section of Breast- and Endocrine Surgery, Department of Surgery, University Hospital of North Norway, Tromsø, Norway
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Eva Sigstad
Eva Sigstad
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Krystyna K. Grøholt
Krystyna K. Grøholt
Department of Pathology, Oslo University Hospital, Oslo, Norway
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Lars H. Jørgensen
Lars H. Jørgensen
Department of Thoracic Surgery, Oslo University Hospital, Oslo, Norway
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Trine Bjøro
Trine Bjøro
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
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disease in the lateral neck [ 3 , 14 ]. High-resolution ultrasound is important in disease staging, enabling the detection of even very small metastatic lymph nodes but not micrometastases. Calcitonin is a good tumor marker in MTC. As a rule, it is
Catarina Silvestre
Catarina Silvestre
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
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Joaquim Sampaio Matias
Joaquim Sampaio Matias
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
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Helena Proença
Helena Proença
Department of Laboratorial Medicine, Santa Maria Hospital, Lisbon, Portugal
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Maria João Bugalho
Maria João Bugalho
Department of Endocrinology, Diabetes and Metabolism, Santa Maria Hospital, Lisbon, Portugal
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Introduction Calcitonin (Ctn) is a 32-amino acid polypeptide secreted by the parafollicular cells of the thyroid, called “C” cells. With a known important role in regulating blood calcium in fish and rodents, the role of Ctn in human calcium
Fabio Maino
Fabio Maino
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Cristina Dalmiglio
Cristina Dalmiglio
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Nicoletta Benenati
Nicoletta Benenati
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Michele Campanile
Michele Campanile
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Tania Pilli
Tania Pilli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Raffaella Forleo
Raffaella Forleo
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Lucia Brilli
Lucia Brilli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Cristina Ciuoli
Cristina Ciuoli
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Silvia Cantara
Silvia Cantara
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Marco Capezzone
Marco Capezzone
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Alessandra Cartocci
Alessandra Cartocci
Department of Medical Biotechnologies, University of Siena, Siena, Italy
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Furio Pacini
Furio Pacini
Humanitas Clinical Institute, Humanitas University, Rozzano, Italy
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Maria Grazia Castagna
Maria Grazia Castagna
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy
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Introduction Calcitonin (CT), a 32-amino acid calcium-lowering peptide secreted by the C-cells (parafollicular cells) of the thyroid, is used as a marker for the diagnosis and the follow-up of medullary thyroid cancer (MTC) [ 1 ]. In patients
Cléber P. Camacho
Cléber P. Camacho
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Susan C. Lindsey
Susan C. Lindsey
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Teresa S. Kasamatsu
Teresa S. Kasamatsu
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Alberto L. Machado
Alberto L. Machado
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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João Roberto M. Martins
João Roberto M. Martins
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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Rosa Paula M. Biscolla
Rosa Paula M. Biscolla
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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Magnus R. Dias da Silva
Magnus R. Dias da Silva
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
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José Gilberto H. Vieira
José Gilberto H. Vieira
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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Rui M.B. Maciel
Rui M.B. Maciel
Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
Fleury Medicine and Health, São Paulo, Brazil
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Fleury Medicine and Health, São Paulo, Brazil
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Introduction Serum calcitonin (sCT) is a useful biomarker for medullary thyroid cancer (MTC) and is employed for its diagnosis and follow-up monitoring [ 1 ]. In addition, some guidelines advocate sCT measurements for the differential
Isabelle Clinckspoor
Isabelle Clinckspoor
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
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Anne-Catherine Gérard
Anne-Catherine Gérard
Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain
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Jacqueline Van Sande
Jacqueline Van Sande
IRIBHM, Université Libre de Bruxelles, Brussels
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Marie-Christine Many
Marie-Christine Many
Pôle de Morphologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain
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Lieve Verlinden
Lieve Verlinden
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
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Roger Bouillon
Roger Bouillon
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
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Geert Carmeliet
Geert Carmeliet
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
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Chantal Mathieu
Chantal Mathieu
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Annemieke Verstuyf
Annemieke Verstuyf
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
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Brigitte Decallonne
Brigitte Decallonne
Clinical and Experimental Endocrinology, Katholieke Universiteit Leuven
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
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antithyroid antibodies and abnormal thyroid function in humans [ 19 , 20 ], and to modulate autoimmune hyperthyroidism in mice [ 21 ]. Apart from inhibiting osteoclast-mediated bone resorption and increasing renal calcium and phosphate excretion, calcitonin
Abbas Al-Kurd
Abbas Al-Kurd
Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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David J. Gross
David J. Gross
Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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David Zangen
David Zangen
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Karine Atlan
Karine Atlan
Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Haggi Mazeh
Haggi Mazeh
Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Simona Grozinsky-Glasberg
Simona Grozinsky-Glasberg
Neuroendocrine Tumor Unit, Department of Endocrinology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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should be revised to recommend calcitonin screening and prophylactic thyroidectomy at an earlier age in such patients. Due to the rarity of these patients, cumulative literature on the topic is essential, and, therefore, reports such as the present one
