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Dear Sir, The results of the long awaited Antenatal Thyroid Screening and Childhood Cognitive Function study have finally been published in the New England Journal of Medicine after a preliminary presentation of findings at the
Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
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Department of Pedagogical, Curricular and Professional Studies, Faculty of Education, University of Gothenburg, Gothenburg, Sweden
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Wallenberg’s Centre of Molecular and Translational Medicine, Region Västra Götaland, Sweden
Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden
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considered separately as the treatment options differ depending on the condition. The aim of this study was to assess mental fatigue, depression, anxiety, and cognitive function in GD patients in the hyperthyroid phase and after 15 months of treatment, with
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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. Secondary outcomes included impacts on heart rate, body composition, and cognitive function. Clinical Parameters QoL was measured by an online version of ThyPRO-39 [ 9 - 12 ]. The questionnaire was answered at home before each visit and 12 months
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, Dhaliwal SS, Chew GT, Bhagat MC, Cussons AJ: Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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hypothyroidism. The primary endpoints of the trial include a combined cardiovascular endpoint and thyroid-specific quality of life. Secondary endpoints include overall mortality, quality of life, functional capacity, and cognitive function. Analyses of this trial
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function is important in early gestation, as the fetus derives maternal thyroid hormone for brain development [ 8 ]. SCH during pregnancy was reportedly associated with reduced childhood cognitive function [ 9 , 10 ]. Normalization of serum TSH with L
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heart disease and mortality. JAMA 2010;304:1365-1374. 10.1001/jama.2010.1361 20858880 4 Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG: Thyroid status, disability and cognitive function, and survival in old age. JAMA
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-0414 16804044 30 Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JG, Wiersinga WM: Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol 2005
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of autoimmune disease on the brain, have to be considered. It is therefore desirable to analyze the influence of an excess of thyroid hormones on brain morphology and cognitive functions in an experimental setting. Such studies have been performed
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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values, support these findings [ 9 , 14 ]. On the other hand, no differences in hypothyroid symptoms, quality of life, or cognitive function were seen in a double-blind, randomized, clinical trial with cross-over design on 52, L-T4-treated, hypothyroid
