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Jeppe Lerche la Cour, Line Tang Møllehave, Bjarke Røssner Medici, Christian Zinck Jensen, Anne Ahrendt Bjerregaard, and Birte Nygaard

increased, and it has been suggested that some hypothyroid patients could improve their quality of life if treated with liothyronine (L-T3) or desiccated thyroid extract (DTE). However, L-T3 and DTE therapy is still controversial among endocrinologists and

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Roberto Negro, Roberto Attanasio, Endre V. Nagy, Enrico Papini, Petros Perros, and Laszlo Hegedüs

efficacy [ 8 , 9 ]. In addition to this, the prevalence of treated hypothyroid individuals is growing [ 10 ], and this is paralleled by an increase in the use of desiccated thyroid extract (DTE) and LT3 + LT4 combination therapy [ 11 ]. Increase in

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Jacqueline Jonklaas, Antonio C. Bianco, Anne R. Cappola, Francesco S. Celi, Eric Fliers, Heike Heuer, Elizabeth A. McAninch, Lars C. Moeller, Birte Nygaard, Anna M. Sawka, Torquil Watt, and Colin M. Dayan

cardiovascular effects is unlikely on low dose combination therapy [ 57 ]. One other randomized crossover trial of combination therapy using desiccated thyroid extract (DTE) has also been conducted in 70 patients who were also crossed over to LT4 monotherapy