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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Malika Ichiche Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Serge Rozenberg Department of Gynecology and Obstetrics, Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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impact of some thyroid parameters on pregnancy outcomes was different according to the foetal gender ( 7 , 8 , 9 ). In the study by Zhang et al. , the lowest percentiles of maternal free T4 (FT4) were associated with a higher birth weight in case of a

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Kris Poppe Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Peter Bisschop Department of Endocrinology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, and Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Gesthimani Minziori Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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David Unuane Department of Internal Medicine, Endocrine Unit, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium

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Andrea Weghofer Department of Gynecological Endocrinology & Reproductive Medicine, Medical University of Vienna, Vienna, Austria

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ejaculation [ 34 ]. A large number of studies have demonstrated adverse effects of hypothyroidism on male fertility in foetal, early neonatal, or even adult life. Increased abnormalities in sperm morphology and motility have been described in case of

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Tim I.M. Korevaar Department of Internal Medicine and the Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands

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Rima Dhillon-Smith Institute of Metabolism and Systems Research, Tommy’s National Centre for Miscarriage Research and the Birmingham Clinical Trials Unit, the Birmingham Women’s and Children’s NHS Foundation Trust, University of Birmingham, Birmingham, United Kingdom

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Arri Coomarasamy Institute of Metabolism and Systems Research, Tommy’s National Centre for Miscarriage Research and the Birmingham Clinical Trials Unit, the Birmingham Women’s and Children’s NHS Foundation Trust, University of Birmingham, Birmingham, United Kingdom

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Robin P. Peeters Department of Internal Medicine and the Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands

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associations of maternal thyroid function with foetal brain development: epidemiological interpretation and overview of available evidence . Clin Endocrinol (Oxf) . 2018 Apr ; 89 ( 2 ): 129 – 38 . 10.1111/cen.13724 29693263 0300-0664 2 Korevaar

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Sze May Ng Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
Department of Paediatrics, Southport and Ormskirk NHS Trust, Ormskirk, United Kingdom

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Mark A. Turner Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

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Shivaram Avula Department of Radiology, Alder Hey Foundation Trust Hospital, Liverpool, United Kingdom

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interaction with other enzyme systems [ 4 ]. The size of the thyroid gland is closely regulated during foetal development [ 5 ]. Abnormal thyroid size is often found in disease states and therefore thyroid volume was thought to correlate with thyroid gland

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Hiroyuki Iwaki Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Kenji Ohba Medical Education Center, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Eisaku Okada Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takeshi Murakoshi Obstetrics and Gynecology, Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Yumiko Kashiwabara Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Chiga Hayashi Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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Akio Matsushita Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Shigekazu Sasaki Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Takafumi Suda Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

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Yutaka Oki Department of Metabolism and Endocrinology, Hamamatsu-Kita Hospital, Hamamatsu, Japan

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Rieko Gemma Division of Endocrinology, Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Japan

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. 10.1056/NEJM198102263040907 6893853 0028-4793 9 Momotani N , Yamashita R , Yoshimoto M , Noh J , Ishikawa N , Ito K . Recovery from foetal hypothyroidism: evidence for the safety of breast-feeding while taking propylthiouracil

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Emna Jelloul Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Georgiana Sitoris Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Flora Veltri Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Pierre Kleynen Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Serge Rozenberg Departement of Gynecology and Obstetrics, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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Kris G Poppe Endocrine Unit Centre Hospitalier Universitaire (CHU) Saint Pierre, Université Libre de Bruxelles (ULB), Rue Haute, Brussels, Belgium

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-2019-0220 ) 24 Sitoris G Veltri F Kleynen P Ichiche M Rozenberg S & Poppe KG . Does foetal gender influence maternal thyroid parameters in pregnancy? European Thyroid Journal 2022 11 e210001 . ( https://doi.org/10.1530/ETJ-21

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Kris Poppe Endocrine Unit, Department of Internal Medicine, University Hospital UZ Brussel (VUB), Brussels, Belgium

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Alicja Hubalewska-Dydejczyk Department of Endocrinology, Jagiellonian University Medical College, Kraków, Poland

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Peter Laurberg Department of Endocrinology and Medicine, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

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Roberto Negro Division of Endocrinology, V. Fazzi Hospital, Lecce

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Francesco Vermiglio Cattedra di Endocrinologia, Policlinico Universitario, Messina, Italy

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Bijay Vaidya Department of Endocrinology, Royal Devon & Exeter Hospital, Exeter, UK

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management of Graves’ disease in pregnancy. Thyroid 1992;2:219–224. 10.1089/thy.1992.2.219 18 Laurberg P, Bournaud C, Karmisholt J, Orgiazzi J: Management of Graves’ hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and

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John H. Lazarus Centre for Endocrine and Diabetes Sciences, Cardiff University, Cardiff, UK

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: Management of Graves’ hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy. Eur J Endocrinol 2009;160:1–8. 10.1530/EJE-08-0663 8 Mestman JH: Hyperthyroidism in

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Berta Soldevila Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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Inés Velasco Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Carla Muñoz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Yesika Díaz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laia Egea-Cortés Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laura Ferrer-Escopiñan Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Alejandra Pérez-Montes de Oca Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Raquel Martínez-Mondejar Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Jordi Casabona Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Manel Puig-Domingo Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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, Impact of TSH during the first trimester of pregnancy on obstetric and foetal complications: usefulness of 2.5 mIU/L cut-off value . Clinical Endocrinology 2018 88 728 – 734 . ( https://doi.org/10.1111/cen.13575 ) 5 Moleti M Trimarchi F

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Suresh Kumar Bunker Department of Biotechnology, Utkal University, Bhubaneswar, India

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Jagneshwar Dandapat Department of Biotechnology, Utkal University, Bhubaneswar, India

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Gagan B.N. Chainy Department of Biotechnology, Utkal University, Bhubaneswar, India

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Sunil Kumar Sahoo Department of Biotechnology, Utkal University, Bhubaneswar, India

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Prabhat Kumar Nayak Department of Biotechnology, Utkal University, Bhubaneswar, India

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-thyroid drugs such as methimazole or PTU during the foetal and neonatal period of vertebrates results in impairment of hepatic gene expression in adulthood [ 3 , 4 ]. DNA methylation, an epigenetic phenomenon, has been recognized as an interface between

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