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Introduction Diagnosis of thyroid disease is based on thyroid-stimulating hormone (TSH) measurement. Occasionally, this measurement may be erroneous due to analytical interference. Clinical biochemists and clinicians need to be aware of this
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interference with TgAb may lead to Tg values that are lower than expected or even undetectable. This Tg underestimation is considered the most serious clinical problem for the clinical follow-up of postoperative patients with DTCs. Liquid chromatography
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interference with daily activities of a symptomatic AE during treatment [ 10 ]. The EQ-5D-3L questionnaire assesses QoL through the EQ-5D descriptive system and the EQ visual analogue scale (EQ-VAS); a score (EQ-5D index) can be calculated combining these data
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Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
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suffer from Tg antibody (TgAb) interference, resulting in a false-negative (i.e. undetectable) or a false-positive Tg value, depending on the assay used ( 2 ). These TgAbs are present in approximately 25–30% of the DTC patients, but the definition of TgAb
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
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Department of Clinical Research, University of Southern Denmark, Odense, Denmark
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. Introduction Despite methodological improvements, immunoassays used for evaluation of the thyroid function are still exposed to different types of interferences. Macro-thyrotropin (macro-TSH) is caused by a large amount of monomeric TSH complexed with anti
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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). Assay interferences Analytical interferences in thyroid function tests (TFTs) can result in diagnostic delays, unnecessary testing, and inappropriate treatments. A recent review of 150 patients with interferences in TFTs shows that in more than 50
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Department of Medicine, University of Udine, Udine, Italy
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with the others ( 4 ). In such cases, analytical interferences should be investigated in order to avoid unnecessary further diagnostic procedures and/or treatments ( 5 ). In fact, despite numerous advances in immunoassay technology, thyroid hormone
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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residues 234–264, 316–347, and 426–454 of thyroid hormone receptor beta. Spurious hyperthyroxinemia due to thyroid function assay interferences is a frequent pitfall in the differential diagnosis of central hyperthyroidism. Novel Insights
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), nephrotic syndrome, liver or pancreatic disease, heart disease, pregnancy and/or interference of absorption by other drugs [ 6 ]. The bioavailability of synthetic levothyroxine is approximately 80% after oral ingestion. Absorption occurs mostly in the
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availability and, hence, to deregulate transcription and TH-induced epigenetic effects on target genes [ 9 ]. Interference with TH production and availability can occur at multiple levels (Fig. 1 ): blocking iodine uptake; inhibition of TH production