Dominik Spira
Dominik Spira
Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Nikolaus Buchmann
Nikolaus Buchmann
Department of Cardiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Marcus Dörr
Marcus Dörr
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
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German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
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Marcello R P Markus
Marcello R P Markus
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
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German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
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Matthias Nauck
Matthias Nauck
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
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Sabine Schipf
Sabine Schipf
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Joachim Spranger
Joachim Spranger
Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Ilja Demuth
Ilja Demuth
Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Charité – Universitätsmedizin Berlin, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Charité – Universitätsmedizin Berlin, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Elisabeth Steinhagen-Thiessen
Elisabeth Steinhagen-Thiessen
Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Henry Völzke
Henry Völzke
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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Till Ittermann
Till Ittermann
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
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with regard to other parameters such as insulin. The strength of this study lies in its large sample size and the combination of two different cohorts covering a large age range that is important since thyroid disease can occur all over the lifespan
Sander Barnhoorn
Sander Barnhoorn
Department of Molecular Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
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Marcel E Meima
Marcel E Meima
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Robin P Peeters
Robin P Peeters
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Veerle M Darras
Veerle M Darras
Laboratory of Comparative Endocrinology, Biology Department, KU Leuven, Leuven, Belgium
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Selmar Leeuwenburgh
Selmar Leeuwenburgh
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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Jan H J Hoeijmakers
Jan H J Hoeijmakers
Department of Molecular Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
Institute for Genome Stability in Ageing and Disease, CECAD Research Centre, Cologne, Germany
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
Institute for Genome Stability in Ageing and Disease, CECAD Research Centre, Cologne, Germany
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Wilbert P Vermeij
Wilbert P Vermeij
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Oncode Institute, Utrecht, The Netherlands
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Oncode Institute, Utrecht, The Netherlands
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W Edward Visser
W Edward Visser
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
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studies in older individuals may hint at increasing healthy lifespan in elderly with a lower thyroid state ( 59 ). The interplay between genetic, metabolic and environmental factors determines a unique thyroid biography in individuals. ( 2 , 60 ). Lastly
Inês Cosme
Inês Cosme
Department of Endocrinology, Unidade Local de Saúde Santa Maria, Lisbon, Portugal
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Ana Figueiredo
Ana Figueiredo
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Sara Pinheiro
Sara Pinheiro
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Department of Endocrinology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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attribute the increasing incidence of TC to overdiagnosis which detects indolent lesions common in the general population and that will not be responsible for symptoms or death during patients’ lifespans. Overdiagnosis can be explained by the frequent use of
Sogol Gachkar
Sogol Gachkar
Molecular Endocrinology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany
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Rebecca Oelkrug
Rebecca Oelkrug
Molecular Endocrinology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany
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Beate Herrmann
Beate Herrmann
Molecular Endocrinology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany
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Thomas S. Scanlan
Thomas S. Scanlan
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon, USA
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Qian Sun
Qian Sun
Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Heike Biebermann
Heike Biebermann
Institute of Experimental Pediatric Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Carolin S. Hoefig
Carolin S. Hoefig
Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Lutz Schomburg
Lutz Schomburg
Institute for Experimental Endocrinology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Jens Mittag
Jens Mittag
Molecular Endocrinology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany
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.1089/thy.2016.0182 27788620 1050-7256 25 Zhang Y , Liu Y , Walsh M , Bokov A , Ikeno Y , Jang YC , et al. Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice . Mech Ageing Dev . 2016 Mar ; 154 : 1 – 8
Georgios K. Markantes
Georgios K. Markantes
Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
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Konstantinos Dimitropoulos
Konstantinos Dimitropoulos
Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
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Irene Mamali
Irene Mamali
Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
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Ioulia Tseti
Ioulia Tseti
Uni-Pharma S.A., Athens, Greece
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George Sakellaropoulos
George Sakellaropoulos
Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece
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Kostas B. Markou
Kostas B. Markou
Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
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Marina A. Michalaki
Marina A. Michalaki
Division of Endocrinology, Department of Internal Medicine, University of Patras Medical School, Patras, Greece
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, available in a 30 mL bottle with a built-in dosimetry dropper device. The proposed lifespan of the product is 18 months, and it is well-preserved at room temperature for 1 month since opening. Twenty drops of the solution contain 100 μg of LT4. Table 1
Barbara A. Demeneix
Barbara A. Demeneix
CNRS/UMR7221, Muséum National d’Histoire Naturelle/Université Paris-Sorbonne, Paris, France
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years after exposure [ 39 ]. Second, the cost of IQ loss or neurodevelopmental disease will have lifelong effects. For instance, treating severe ASD with intellectual deficiency can cost upwards of EUR 80,000 per year during the whole lifespan, whereas
Salman Razvi
Salman Razvi
Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom
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Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom
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Vicky Ryan
Vicky Ryan
Institute of Health and Society, Newcastle University, Newcastle, United Kingdom
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Lorna Ingoe
Lorna Ingoe
Department of Endocrinology, Gateshead Health NHS Foundation Trust, Gateshead, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
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Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
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Simon H. Pearce
Simon H. Pearce
Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom
Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
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Department of Endocrinology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom
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Scott Wilkes
Scott Wilkes
School of Medicine, University of Sunderland, Sunderland, United Kingdom
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Background Worldwide, there has been an increase in human lifespan and reduction in early mortality. These 2 factors and the associated reduction in the number of childbirths have led to an increase in the proportion of older
Ángel García-Aldea
Ángel García-Aldea
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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Marina Guillén-Yunta
Marina Guillén-Yunta
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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Víctor Valcárcel-Hernández
Víctor Valcárcel-Hernández
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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Ana Montero-Pedrazuela
Ana Montero-Pedrazuela
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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Ana Guadaño-Ferraz
Ana Guadaño-Ferraz
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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Soledad Bárez-López
Soledad Bárez-López
Instituto de Investigaciones Biomédicas Sols-Morreale, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain
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be explored. Another aspect to consider is whether AHDS patients maintain their hearing capacity throughout their entire lifespan or whether they are prone to hearing loss due to deficient TH signalling. Vision TH action is also essential for
Kris Poppe
Kris Poppe
Endocrine Unit, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
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Peter Bisschop
Peter Bisschop
Department of Endocrinology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, and Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Gesthimani Minziori
Gesthimani Minziori
Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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David Unuane
David Unuane
Department of Internal Medicine, Endocrine Unit, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
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Andrea Weghofer
Andrea Weghofer
Department of Gynecological Endocrinology & Reproductive Medicine, Medical University of Vienna, Vienna, Austria
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Embryo Development Thyroid Disorders and Ovarian Reserve Ovarian senescence is closely associated with the depletion of a woman’s follicular pool during her reproductive lifespan. Although recently challenged by reports on ovarian stem cells, the
