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microchimerism Fetal cells (including cytotoxic T cells) migrate to mother and trigger immune response. The role of non-coding RNA in AITD NcRNAs are defined as untranslated RNA molecules that regulate gene expression. ncRNAs are categorized
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, Lloyd RV: Non-coding RNAs in thyroid cancer. Endocr Pathol 2016;27: 12–20. 10.1007/s12022-016-9417-8 26847830 29 Wang X-Z, Hang Y-K, Liu J-B, Hou Y-Q, Wang N, Wang M-J: Over-expression of microRNA-375 inhibits papillary thyroid carcinoma cell
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
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Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal
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). DICER1 is a member of the RNAse III family that plays a key role in the biogenesis involved in the processing of small non-coding RNAs (microRNAs), potentially affecting gene regulation at the post-transcriptional level. Since the first report in 2001
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cellular plasticity at the gene regulation level and transgenerational, epigenetic heredity. Although many cellular factors are implicated (including polycomb proteins, non-coding RNAs, microRNAs, and the 3D chromatin architecture itself), succinctly, the
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, Slack FJ: Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 2008;9:219-230. 10.1038/nrm2347 18270516 10 Leone V, D'Angelo D, Ferraro A, Pallante P, Rubio I, Santoro M, Croce CM, Fusco A: A TSH-CREB1-microRNA loop is required for
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-like gene 1 (RTL1), as well as the non-coding RNA sequences Gtl2 (MEG3), Rian (MEG8), MIRG, and numerous miRNAs [ 62 ]. Activation of the DLK1-DIO3 region is an aspect of increased pluripotency and proliferative activity in stem cells and various tumors [ 63
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& Ghafouri-Fard S . Dysregulation of non-coding RNAs in autoimmune thyroid disease . Experimental and Molecular Pathology 2020 117 104527 . ( https://doi.org/10.1016/j.yexmp.2020.104527 ) 32 Masetti G & Ludgate M . Microbiome and Graves
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small, single-stranded, non-coding RNAs that play a role in regulating biological processes by inhibiting gene expression at the post-transcriptional level. They have emerged as crucial modulators of immunity and cellular processes ( 12 ). Only a few