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Introduction Pediatric differentiated thyroid carcinoma (DTC) is a rare disease; however, its worldwide incidence is rising ( 1 , 2 ). DTC comprises several histological subtypes, with papillary thyroid carcinoma (PTC) accounting for the vast
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Department of Pediatric Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Endocrine Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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) and thyroid surgery – the benefits and risks of each modality are different in the young. The European Thyroid Association (ETA) guideline addresses the etiology, diagnosis and prognosis of pediatric GD patients with and without orbitopathy and
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Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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). Previous studies have suggested some clinical differences between prepubertal and pubertal pediatric DTC. Prepubertal patients present with a greater prevalence of lymph node ( 4 , 5 ) and lung metastasis ( 6 ) at diagnosis than pubertal patients. At the
Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands
Amsterdam Reproduction & Development Research Institute, Amsterdam, The Netherlands
Endocrine Laboratory, Department of Laboratory Medicine, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands
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studies on isolated central CH have been reported. Nebesio et al. evaluated retrospectively medical charts of children with central CH seen at a pediatric endocrinology department over a 17-year period, during which the study region’s screening consisted
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and physicians, and depends on patient characteristics and preferences. Yet, for newly diagnosed pediatric GD patients, ATDs are predominantly first-line treatment in Europe and are generally well tolerated [ 2 , 3 ]. Unfortunately, the overall
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first-line treatment modality in newly diagnosed pediatric GD patients [ 3 - 5 ]. Unfortunately, the relapse frequency of hyperthyroidism is high in this age group, with only 20–30% reaching long-lasting remission after 2 years of ATD treatment [ 5
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Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Graphical abstract Introduction Papillary thyroid carcinoma (PTC) is the most common pediatric endocrine malignancy. While long-term disease-specific survival approaches 100% for children and adolescents ( 1 , 2 ), recurrence
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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Wellcome Trust-MRC Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK
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Department of Endocrinology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK
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Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
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.1089/thy.2016.0229 ) 4 Van Veenendaal NR Rivkees SA . Treatment of pediatric Graves’ disease is associated with excessive weight gain . Journal of Clinical Endocrinology and Metabolism 2011 96 3257 – 3263 . ( https://doi.org/10.1210/jc.2011
Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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Department of Endocrinology, Universidade Federal do Rio de Janeiro – UFRJ, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil
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, RAI therapy after the age of 19 years, and a history of medical treatment or conditions with the potential of decreasing ovarian reserve. We established the age cutoff of 19 years, as this age separates pediatric and adult individuals, according to the
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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thyroid surveillance recommendations for PHTS patients have been proposed [ 3 - 7 ]. The National Comprehensive Cancer Network (NCCN) in the USA recommends that pediatric PHTS patients receive an annual thyroid ultrasound from the age of diagnosis