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Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada
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and/or pituitary gland. TSH deficiency can occur in isolation or in the context of combined pituitary hormone deficiency ( 1 , 2 ). Isolated CCH has thus far been associated with mutations in five genes in humans: TSHB , TRHR , IGSF1 , TBL1X , and
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Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany
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Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
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DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany
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Introduction Thyroid hormones (TH) affect cellular metabolism and thereby have vital functions for growth and metabolic homeostasis ( 1 ). Thyroid function is governed by the hypothalamic–pituitary–thyroid (HPT) axis, where the thyrotropin
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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Department of Internal Medicine & Pediatrics, Ghent University, Ghent, Belgium
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). CHT is a rare condition, accounting for about 1 in 1000 hypothyroid patients, and is typically observed in patients with hypothalamic (tertiary hypothyroidism) or pituitary (secondary hypothyroidism) pathology ( 1 , 2 ). It can be isolated, which is
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putative transmembrane domains and both, the N- and the C-terminal domains, are located intracellularly [ 20 , 21 ]. In humans, MCT8 mRNA was found to be highly expressed in liver, kidney, heart, placenta, lung, thyroid as well as in brain and pituitary
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Introduction The syndrome of ‘inappropriate secretion of TSH' was the term coined originally [ 1 ] to indicate two forms of central hyperthyroidism, i.e. thyrotropin (TSH)-secreting pituitary adenomas (TSHomas) and resistance to thyroid
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Institute of Pathology, Medical University of Graz, Graz, Austria
Institute for Clinical Pathology, Johannes Kepler University, Linz, Austria
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Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
Department of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria
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What Is Known about This Topic? The differential diagnosis of secondary hyperthyroidism may lead to several challenges. Although very rare, ectopic thyrotropin-secreting neuroendocrine pituitary tumors (TSH-PitNETs) need to be
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Introduction Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is a rare tumor and represents less than 2% of all pituitary tumors [ 1 , 2 , 3 ]. The coexistence of autoimmune thyroid disease and TSHoma
Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Azienda USL, Modena, Italy
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Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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Center of Genomic Research, University of Modena and Reggio Emilia
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Azienda USL, Modena, Italy
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Center of Genomic Research, University of Modena and Reggio Emilia
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predetermined ‘thyroid function set-point' has been hypothesized so that the individual genetic background influences the regulation of the hypothalamo-pituitary-thyroid (HPT) axis [ 15 ]. Because of the absence of residual thyroid function, thyroidectomized
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Endocrine Surgery Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Institute of Pathology, Clinical Center of Serbia, Belgrade, Serbia
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Neuroendocrine Department, Diabetes and Metabolic Diseases, Clinical Center of Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia
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What Is Known about This Topic? • Sellar masses most commonly represent pituitary adenoma, and only rarely metastatic tumors, usually originating from breast or lung carcinoma. Accelerated growth of a sellar mass, rapid onset of diabetes
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) has a permissive effect on reproduction. Hypothyroidism has been shown to have a suppressive effect on the function of the hypothalamo-pituitary-gonadal (HPG) axis in both men [ 2 - 7 ] and women [ 8 ]. However, while there are a number of studies on