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Junyu Tong Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Maomei Ruan Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

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Yuchen Jin Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Hao Fu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Lin Cheng Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Qiong Luo Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Zhiyan Liu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China
Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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Zhongwei Lv Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

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Libo Chen Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China

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thyroid carcinoma derived from follicular epithelial cells, poorly differentiated thyroid carcinoma (PDTC) ranks between DTC and ATC regarding the degree of differentiation ( 4 ). PDTC was initially proposed as a separate entity by Sakamoto et al. in

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João Roque Endocrinology, Diabetes and Metabolism Department, Centro Hospitalar Universitário Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal

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Tiago Nunes Silva Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Catarina Regala Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Ricardo Rodrigues Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology, Diabetes and Metabolism Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
NOVA Medical School | Faculdade de Ciências Médicas of Universidade NOVA de Lisboa, Lisbon, Portugal
Unidade Investigação Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Introduction The term poorly differentiated thyroid carcinoma (PDTC) was first introduced by Granner and colleagues in 1963, although it was only recognized as a distinct entity by the World Health Organization in 2004 ( 1 , 2 ). In 2006, the

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Tiago Nunes da Silva Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Edward Limbert Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Introduction Poorly differentiated thyroid carcinoma (PDTC) is a rare type of thyroid cancer accounting for < 6% of all thyroid malignancies [ 1 ]. Nevertheless, it is the second cause of death from follicular cell-derived thyroid cancer after

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Janice Ser Huey Tan Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Timothy Kwang Yong Tay Department of Pathology, Singapore General Hospital, Singapore

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Enya Hui Wen Ong Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Michael Fehlings ImmunoScape, 1 Scotts Road #24-10, Singapore

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Daniel Shao-Weng Tan Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Nadiah Binte Sukma Department of Pathology, Singapore General Hospital, Singapore

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Eileen Xueqin Chen Department of Pathology, Singapore General Hospital, Singapore

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Jen-Hwei Sng Department of Pathology, Singapore General Hospital, Singapore

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Connie Siew Poh Yip Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Kok Hing Lim Department of Pathology, Singapore General Hospital, Singapore

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Darren Wan-Teck Lim Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Narayanan Gopalakrishna Iyer Division of Surgical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Jacqueline Siok Gek Hwang Department of Pathology, Singapore General Hospital, Singapore

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Melvin Lee Kiang Chua Division of Radiation Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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Mei-Kim Ang Division of Medical Oncology, National Cancer Centre Singapore, Hospital Boulevard, Singapore

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combination treatment in 8 patients with metastasized anaplastic (ATC) or poorly differentiated thyroid carcinoma (PDTC) . Annals of Oncology 2018 29 viii646 . ( https://doi.org/10.1093/annonc/mdy302.004 ) 17 Dierks C Seufert J Aumann K Ruf J Klein

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Claudia Matta-Coelho Serviço de Endocrinologia, Hospital de Braga, Braga, Portugal
Center for Health Technology and Services Research (CINTESIS), Porto, Portugal

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Joana Simões-Pereira Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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Helena Vilar Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Serviço de Endocrinologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

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treatment (surgery plus RAIT), Tg levels under levothyroxine suppression were elevated in 73 of 75 patients, and the remaining 2 patients had a serum Tg < 0.2 ng/mL. One was a patient with a poorly differentiated thyroid carcinoma (PDTC), negative anti

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Francisco Sousa Santos Endocrinology Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Rita Joana Santos Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculty of Medical Sciences of Lisbon, Lisbon, Portugal

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DTC or poorly differentiated thyroid carcinoma (PDTC) (Table 1 ). Of these, a total of 8 patients were excluded from the analysis for the following reasons: 6 because they did not complete more than 2 months of therapy (5 died as a consequence of

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Laura Fugazzola Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Rossella Elisei Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Dagmar Fuhrer Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany

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Barbara Jarzab Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France

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Kate Newbold Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom

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Jan Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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tumours are regarded as a separate group. The HC carcinomas are divided into minimally invasive, encapsulated angioinvasive, and widely invasive subtypes, following the same criteria as those applied to FTC. Poorly differentiated thyroid carcinoma (PDTC

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Daniela Dias Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Inês Damásio Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Pedro Marques Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisbon, Portugal

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Helder Simões Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Ricardo Rodrigues Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Branca Maria Cavaco Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

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Valeriano Leite Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal

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Bardet S & French TUTHYREF N etwork . Unusual short-term complete response to two regimens of cytotoxic chemotherapy in a patient with poorly differentiated thyroid carcinoma . Journal of Clinical Endocrinology and Metabolism 2012 97 3046 – 3050

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Camille Buffet Department of Thyroid Pathologies and Endocrine Tumors, AP-HP, Pitié-Salpêtrière Hospital, Groupe de Recherche Clinique n°16 Tumeurs Thyroïdiennes, Sorbonne Université, Paris, France
UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France

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Sophie Leboulleux Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institut, Villejuif, France

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Françoise Kraeber-Bodéré Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Caroline Bodet-Milin Nuclear Medicine Department, Université de Nantes, CHU de Nantes, CNRS, Inserm, CRCINA, Nantes, France
CHU Nantes/ICO, Saint-Herblain, France

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Laure Cabanes Department of Cardiology, APHP, Cochin Hospital, Paris, France
Université de Paris, Paris, France

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Anthony Dohan Radiology Department, Université de Paris, Paris, France
Department of Radiology, AP-HP, Hôpital Cochin, Paris, France

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Pascal Leprince Department of Thoracic and Cardiovascular Surgery, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Paris, France

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Martin Schlumberger UMR9019, Genome Integrity and Cancers, CNRS, Villejuif, France
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy Institute, Villejuif, France

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Olivier Huillard Université de Paris, Sorbonne Paris Cité, Paris, France
Department of Medical Oncology, AP-HP, Hôpital Cochin, Paris, France

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Lionel Groussin INSERM Unité 1016, CNRS UMR 8104, Institut Cochin, Paris, France
Université de Paris, Paris, France
Department of Endocrinology, AP-HP, Hôpital Cochin, Paris, France

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metastases of poorly differentiated thyroid carcinoma diagnosed by echocardiography and magnetic resonance imaging–case report and review of literature . Echocardiography . 2012 ; 29 ( 2 ): E30 – 3 . http://dx.doi.org/10.1111/j.1540-8175.2011.01549.x

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Tim Brandenburg Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Philipp Muchalla Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Sarah Theurer Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
University Duisburg-Essen, Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Kurt Werner Schmid Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
University Duisburg-Essen, Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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Dagmar Führer Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany
Endocrine Tumour Center at West German Cancer Center, Member of ENDO-ERN and EURACAN, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

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pathology revealed a poorly differentiated thyroid carcinoma. Additional workup including esophagogastroduodenoscopy (EGD) showed compression of the oesophagus but no oesophageal infiltration by the tumour. A percutaneous endoscopic gastrostomy tube was

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