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Xian Qiu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Lin Cheng Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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Ri Sa Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, China

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Hao Fu Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, Xiamen, China

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Yuchen Jin Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

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Libo Chen Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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into two clinical situations: TKI-naive patients with RR-DTC diagnosed after 131 I therapy (initial treatment group) and patients with RR-DTC who had failed to first-line sorafenib treatment (salvage treatment group). Patients with concurrent cancers

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Zhen Gao The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Hongtao Zhang The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Lijuan Zhang The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Huimin Yu The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Xuemin Di The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Zeyang Wang The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Zezhou Liu The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Aixia Sui The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Juan Wang The First Department of Oncology, Hebei General Hospital, Shijiazhuang, China

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Gaofeng Shi Department of Radiology, The 4th Affiliated Hospital of Hebei Medical University, Shijiazhuang, China

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-guided 125 I seed brachytherapy as salvage treatment. A literature search of PubMed shows that there is only one other study on the use of 125 I seed implantation for the treatment of recurrent PTC. In this previous study by Parker et al. [ 13 ], a patient

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Samuel Chan Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Katarina Karamali Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Anna Kolodziejczyk Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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Georgios Oikonomou Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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John Watkinson Department of Ear, Nose, and Throat Surgery, GOSH, London, United Kingdom

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Vinidh Paleri The Royal Marsden Hospital, London, United Kingdom

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Iain Nixon Department of Ear, Nose, and Throat Surgery, NHS Lothian, University of Edinburgh, Edinburgh, United Kingdom

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Dae Kim Department of Ear, Nose, and Throat Surgery, St George’s Hospital, London, United Kingdom

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WDTC.” Ease of salvage treatment is dependent on the site of recurrence, with patients presenting with multiple surgeries or distant metastases demonstrating significantly worse overall or disease-specific survival, or disease control [ 29 - 32 ]. In

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