Elisa Minaldi
Elisa Minaldi
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Virginia Cappagli
Virginia Cappagli
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Laura Valerio
Laura Valerio
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Carlotta Giani
Carlotta Giani
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Matilde Viglione
Matilde Viglione
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Laura Agate
Laura Agate
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Introduction Thanks to the results of DECISION and SELECT trials, sorafenib and lenvatinib are the only MKIs approved by both the U.S. Food and Drug Administration (FDA) and the European Medical Agency (EMA) for the first-line treatment of
Xian Qiu
Xian Qiu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Lin Cheng
Lin Cheng
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Ri Sa
Ri Sa
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, China
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Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, China
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Hao Fu
Hao Fu
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, Xiamen, China
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Yuchen Jin
Yuchen Jin
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
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Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
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Libo Chen
Libo Chen
Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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, including chemotherapy and external beam radiation therapy, remains limited in these challenging settings. In recent years, tyrosine kinase inhibitors (TKIs) such as sorafenib and lenvatinib have highlighted new therapeutic options for the treatment of
Laura Ximena Kattah Martinez
Laura Ximena Kattah Martinez
Pontificia Universidad Javeriana, Bogotá, Colombia
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Lisseth Fernanda Marín Carrillo
Lisseth Fernanda Marín Carrillo
Pontificia Universidad Javeriana, Bogotá, Colombia
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Leonardo Rojas Melo
Leonardo Rojas Melo
Pontificia Universidad Javeriana, Bogotá, Colombia
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What Is Known About This Topic? Several side effects have been described with the use of tyrosine kinase inhibitors like sorafenib. Nonetheless, only 9 cases of pancreatitis related to sorafenib treatment have been described, all of them
Francisco Sousa Santos
Francisco Sousa Santos
Endocrinology Department, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Rita Joana Santos
Rita Joana Santos
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Faculty of Medical Sciences of Lisbon, Lisbon, Portugal
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Faculty of Medical Sciences of Lisbon, Lisbon, Portugal
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objective of inhibiting the MAPK pathway and angiogenesis [ 3 ]. Sorafenib, a TKI which inhibits VEGFR 1, 2, and 3, RET (including RET/PTC), RAF (including BRAFV600E), and platelet-derived growth factor receptor beta (PDGFRβ), has already been evaluated in
Zoe A. Efstathiadou
Zoe A. Efstathiadou
Department of Endocrinology, “Hippokration” General Hospital of Thessaloniki, Thessaloniki, Greece
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Charalambos Tsentidis
Charalambos Tsentidis
Department of Endocrinology, General Hospital of Nikaia “Agios Panteleimon”, Piraeus, Greece
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Alexandra Bargiota
Alexandra Bargiota
Department of Endocrinology, University of Thessaly, Larisa, Greece
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Vasiliki Daraki
Vasiliki Daraki
Department of Endocrinology, University Hospital of Crete, Heraklion, Greece
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Kalliopi Kotsa
Kalliopi Kotsa
Department of Endocrinology, “Ahepa” Hospital, Aristotle University, Thessaloniki, Greece
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Georgia Ntali
Georgia Ntali
Department of Endocrinology, Diabetes and Metabolism, “Evangelismos” Hospital Athens, Athens, Greece
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Labrini Papanastasiou
Labrini Papanastasiou
Department of Endocrinology and Diabetes Center, Athens General Hospital “G. Gennimatas”, Athens, Greece
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Stelios Tigas
Stelios Tigas
Department of Endocrinology, University of Ioannina, Ioannina, Greece
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Konstantinos Toulis
Konstantinos Toulis
Department of Endocrinology, 424 Military Hospital, Thessaloniki, Greece
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Kalliopi Pazaitou-Panayiotou
Kalliopi Pazaitou-Panayiotou
Division of Endocrinology, Endocrine Oncology, Interbalkan Medical Center, Thessaloniki, Greece
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Maria Alevizaki
Maria Alevizaki
Endocrine Unit, Department of Medical Therapeutics, School of Medicine, Kapodistrian University of Athens, Athens, Greece
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cabozantinib OR crizotinib OR dasatinib OR erlotinib OR imatinib OR ibrutinib OR lapatinib OR midostaurin OR neratinib OR nilotinib OR pacritinib OR pazopanib OR ponatinib OR regorafenib OR sorafenib OR sunitinib OR vandetanib OR ziv-aflibercept OR gefitinib OR
Daniela Dias
Daniela Dias
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Inês Damásio
Inês Damásio
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Pedro Marques
Pedro Marques
Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte (CHULN), Lisbon, Portugal
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Helder Simões
Helder Simões
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Ricardo Rodrigues
Ricardo Rodrigues
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Branca Maria Cavaco
Branca Maria Cavaco
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
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Valeriano Leite
Valeriano Leite
Endocrinology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal
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Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal
Nova Medical School: Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisbon, Portugal
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MKIs sorafenib and lenvatinib for the treatment of metastatic progressive differentiated thyroid cancer (DTC) of follicular origin. These drugs now play a major role as first-line targeted therapy for such tumors. Progression-free survival was 10
Kirsten E. Stewart
Kirsten E. Stewart
Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom
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Mark W.J. Strachan
Mark W.J. Strachan
Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom
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Devraj Srinivasan
Devraj Srinivasan
Department of Oncology, Western General Hospital, Edinburgh, United Kingdom
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Morna MacNeill
Morna MacNeill
Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
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Lucy Wall
Lucy Wall
Department of Oncology, Western General Hospital, Edinburgh, United Kingdom
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Iain J. Nixon
Iain J. Nixon
Department of Head and Neck Surgery, St John’s Hospital at Howden, Livingston, United Kingdom
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deemed unsuitable for surgery, limited alternative options were available. Sorafenib and lenvatinib both showed a prolonged progression-free survival advantage in patients with radioactive iodine-refractory differentiated thyroid cancer (DTC
Laura Fugazzola
Laura Fugazzola
Division of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Rossella Elisei
Rossella Elisei
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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Dagmar Fuhrer
Dagmar Fuhrer
Department of Endocrinology, Diabetes and Metabolism, Endocrine Tumour Center at West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany
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Barbara Jarzab
Barbara Jarzab
Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Institute, Oncology Center, Gliwice Branch, Gliwice, Poland
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Sophie Leboulleux
Sophie Leboulleux
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay, Villejuif, France
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Kate Newbold
Kate Newbold
Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom
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Jan Smit
Jan Smit
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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.g. sorafenib and lenvatinib. The efficacy of both drugs has been demonstrated in phase III studies (DECISION study for sorafenib [ 13 ] and SELECT study for lenvatinib [ 14 ] and has been confirmed in “real-life” studies [ 15 - 19 ]. Although criteria for
Marine Sitbon
Marine Sitbon
Pharmacy Department, Hospital Saint-Louis APHP, Paris, France
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Porhuoy Chou
Porhuoy Chou
Endocrine Oncology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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Seydou Bengaly
Seydou Bengaly
Endocrine Oncology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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Brigitte Poirot
Brigitte Poirot
Department of Molecular Oncology, Saint-Louis Hospital (AP-HP), Université Paris Cité INSERM U 944, CNRS UMR 7212, Paris, France
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Marie Laloi-Michelin
Marie Laloi-Michelin
Department of Internal Medicine, Hospital Lariboisière APHP, Paris, France
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Laure Deville
Laure Deville
Pharmacy Department, Hospital Saint-Louis APHP, Paris, France
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Atanas Pachev
Atanas Pachev
Radiology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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Ahouefa Kowo-Bille
Ahouefa Kowo-Bille
Endocrine Oncology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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Clement Dumont
Clement Dumont
Medical Oncology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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Cécile N Chougnet
Cécile N Chougnet
Endocrine Oncology Department, Saint-Louis Hospital (AP-HP), Université Paris Cité, Paris, France
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patient refused vandetanib treatment. Similarly, another team showed a rapid response with sorafenib, but sorafenib was not approved for MTC ( 10 ). Here, we report successful treatment of Cushing’s syndrome with RET-targeted therapy in a patient with
Jihwan Yoo
Jihwan Yoo
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
College of Medicine, Yonsei University, Seoul, Republic of Korea
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College of Medicine, Yonsei University, Seoul, Republic of Korea
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Hee Jun Kim
Hee Jun Kim
Department of Surgery, CHA Ilsan Medical Center, Cha University School of Medicine, Goyang-si, Republic of Korea
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Seok Mo Kim
Seok Mo Kim
Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Republic of Korea
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Hun Ho Park
Hun Ho Park
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
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number of brain metastases). Progressive thyroid cancer was preferentially treated with RAI therapy; TKIs, including sorafenib or lenvatinib, were administered when the cumulative RAI dose exceeded 600 mCi. Following the confirmation of brain metastasis
