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Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yoshitaka Hobo ASKA Pharmamedical Co., Ltd. Fujisawa, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Yasuhiro Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Miyoko Higuchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuyoshi Hirokawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takashi Akamizu Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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been used to evaluate structural recurrence in patients with thyroid cancer and positive TgAb in several clinical trials ( 6 , 9 , 10 ). However, no clear advantage has been proven for Tg-LC-MS/MS over immunoassays because of undetectable Tg values in

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Amanda La Greca Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Bin Xu Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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Ronald Ghossein Department of Pathology, Memorial Sloan-Kettering Cancer Center and Weill-Cornell College of Medicine, New York, N.Y., USA

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R. Michael Tuttle Endocrinology Service, Department of Medicine, New York, N.Y., USA

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Mona M. Sabra Endocrinology Service, Department of Medicine, New York, N.Y., USA

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]. In the absence of studies estimating the risk of structural recurrence in these patients, the treating physician often errs on the side of caution, electing to administer RAI ablation to patients presenting with multifocal macroscopic papillary

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Saleha Babli Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

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Richard J.  Payne Department of Otolaryngology, Royal Victoria Hospital, McGill University, Montreal, Québec, Canada

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Elliot Mitmaker Department of Surgery, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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Juan Rivera Division of Endocrinology and Metabolism, Department of Medicine, Montreal General Hospital, McGill University, Montreal, Québec, Canada

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positive TgAb. This patient was operated in 2007, and initial evaluation showed declining TgAb level as well as negative neck US and iodine whole-body scan; however, 3 years later, TgAb started to rise. Structural recurrence was confirmed by neck US (PTC

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Yalin Iscan Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Ismail Cem Sormaz Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Fatih Tunca Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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Yasemin Giles Senyurek Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

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study by Hay et al. [ 18 ], 17% of PMC patients received postoperative RAI ablation treatment, and structural recurrence was reported during follow-up. However, in the study by Pelizzo et al. [ 7 ] 64.5% of PMC patients received postoperative radioactive

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Ayanthi Wijewardene Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Matti Gild Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Carolina Nylén Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Geoffrey Schembri Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Paul Roach Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Jeremy Hoang Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Nuclear Medicine Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Ahmad Aniss Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Anthony Glover Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Mark Sywak Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Stan Sidhu Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
Endocrine Surgery Department, Royal North Shore Hospital, Sydney, New South Wales, Australia

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Diana Learoyd Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Bruce Robinson Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Lyndal Tacon Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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Roderick Clifton-Bligh Department of Endocrinology, Royal North Shore Hospital, Sydney, New South Wales, Australia
Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia

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shifted over the past decade towards the use of lower RAI activities. The HiLo and ESTIMABL1 studies showed no difference in biochemical or structural recurrence following 1.1 GBq (29.7 mCi) or 3.7 GBq (100 mCi) for low-risk patients treated with ablative

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Nicholas S. Andresen Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Buatti Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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Hamed H. Tewfik Iowa City Cancer Treatment Center, Iowa City, Iowa, USA

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Nitin A. Pagedar Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USA

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Carryn M. Anderson Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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John M. Watkins Department of Radiation Oncology, University of Iowa, Iowa City, Iowa, USA

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39 Kruijff S, Aniss AM, Chen P, Sidhu SB, Delbridge LW, Robinson B, Clifton-Bligh RJ, Roach P, Gill AJ, Learoyd D, Sywak MS: Decreasing the dose of radioiodine for remnant ablation does not increase structural recurrence rates in papillary thyroid

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Jiahui Wu Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Xunyang Hu Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Paula Seal EFW Radiology, Calgary, Alberta, Canada
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Parthiv Amin Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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Brendan Diederichs Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Mayfair Radiology, Calgary, Alberta, Canada

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Ralf Paschke Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

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risk (RR) thyroid cancer patients with a median FU of 10 years further demonstrated false-positive ultrasound abnormalities in 57% and structural recurrence in only 10% ( 4 ). Based on these findings, the authors suggested surveillance neck ultrasound

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