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been used to evaluate structural recurrence in patients with thyroid cancer and positive TgAb in several clinical trials ( 6 , 9 , 10 ). However, no clear advantage has been proven for Tg-LC-MS/MS over immunoassays because of undetectable Tg values in
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]. In the absence of studies estimating the risk of structural recurrence in these patients, the treating physician often errs on the side of caution, electing to administer RAI ablation to patients presenting with multifocal macroscopic papillary
Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
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positive TgAb. This patient was operated in 2007, and initial evaluation showed declining TgAb level as well as negative neck US and iodine whole-body scan; however, 3 years later, TgAb started to rise. Structural recurrence was confirmed by neck US (PTC
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study by Hay et al. [ 18 ], 17% of PMC patients received postoperative RAI ablation treatment, and structural recurrence was reported during follow-up. However, in the study by Pelizzo et al. [ 7 ] 64.5% of PMC patients received postoperative radioactive
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shifted over the past decade towards the use of lower RAI activities. The HiLo and ESTIMABL1 studies showed no difference in biochemical or structural recurrence following 1.1 GBq (29.7 mCi) or 3.7 GBq (100 mCi) for low-risk patients treated with ablative
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39 Kruijff S, Aniss AM, Chen P, Sidhu SB, Delbridge LW, Robinson B, Clifton-Bligh RJ, Roach P, Gill AJ, Learoyd D, Sywak MS: Decreasing the dose of radioiodine for remnant ablation does not increase structural recurrence rates in papillary thyroid
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risk (RR) thyroid cancer patients with a median FU of 10 years further demonstrated false-positive ultrasound abnormalities in 57% and structural recurrence in only 10% ( 4 ). Based on these findings, the authors suggested surveillance neck ultrasound