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Laura Tosatto Human Technopole, Milano, Italy

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Francesca Coscia Human Technopole, Milano, Italy

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Introduction: thyroglobulin in thyroid hormone homeostasis The two thyroid hormones (TH) 3,5,3',5'-tetraiodo- l -thyronine (T4) and 3,3′,5-triiodo- l -thyronine (T3) are crucial for human metabolism and development ( 1 , 2 ). T4 is produced

Article Type:
Review Article
Collections:
Environment and thyroid function
DOI:
https://doi.org/10.1530/ETJ-22-0046
Volume/Issue:
Volume 11: Issue 3
Open access
Bernadette L Dekker Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anouk N A van der Horst-Schrivers Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Department of Emergency Medicine, Maastricht University Medical Center, Maastricht, the Netherlands

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Adrienne H Brouwers Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Christopher M Shuford Laboratory Corporation of America Holdings, Center for Esoteric Testing, Burlington, North California, USA

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Ido P Kema Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Anneke C Muller Kobold Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Thera P Links Internal Medicine, Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

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Introduction In the follow-up of patients with differentiated thyroid carcinoma (DTC), thyroglobulin (Tg) is a well-recognized tumor marker, and therefore, highly accurate Tg measurements are crucial ( 1 ). However, current immunoassays can

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0137
Volume/Issue:
Volume 11: Issue 6
Open access
Shaodong Hou Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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Yiceng Sun Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Zeyu Yang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Mi Tang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Tingjie Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cong Shao Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Cunye Yan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Linlong Mo Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Yuquan Yuan Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Supeng Yin Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China

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Fan Zhang Department of Breast and Thyroid Surgery, Chongqing General Hospital, Chongqing, China
Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China

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frozen sections is relatively high, this approach still has some drawbacks, such as the requirement of some advanced equipment and experienced pathologists. Thyroglobulin (Tg) is a macromolecular tetrameric glycoprotein with a molecular weight of 600

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0182
Volume/Issue:
Volume 13: Issue 1
Open access
Nianting Ju Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Liying Hou Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hongjun Song Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhongling Qiu Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yang Wang Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Zhenkui Sun Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Quanyong Luo Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chentian Shen Department of Nuclear Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

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considered to be a significant treatment for eliminating the remnant thyroid tissue after thyroidectomy, which can increase the specificity of detectable serum thyroglobulin (Tg) as a tumor marker and potentially improve the quality of future 131 I whole

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-22-0219
Volume/Issue:
Volume 12: Issue 4
Open access
Carla Gambale Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Alessandro Prete Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Lea Contartese Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Liborio Torregrossa Department of Surgical, Medical, Molecular Pathology and Critical Area, Anatomic Pathology Section, University Hospital of Pisa, Pisa, Italy

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Francesca Bianchi Department of Nuclear Medicine, University Hospital of Pisa, Pisa, Italy

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Eleonora Molinaro Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Gabriele Materazzi Department of Surgical, Medical, Molecular Pathology and Critical Area, Unit of Endocrine Surgery, University Hospital of Pisa, Pisa, Italy

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Rossella Elisei Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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Antonio Matrone Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Pisa, Italy

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pathologic factors, including the ATA class of risk. BiR/InR were defined according to ATA 2015 guidelines as follows: BiR in case of thyroglobulin value on levothyroxine therapy (LT4-Tg) ≥1 ng/mL or Tg peak after recombinant human TSH stimulation (rhTSH

Article Type:
Research Article
Collections:
Thyroid cancer - clinical
DOI:
https://doi.org/10.1530/ETJ-23-0052
Volume/Issue:
Volume 12: Issue 6
Open access
Marta Amaro da Silveira Duval Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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André Borsatto Zanella Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Patrícia Cristo Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Carlo Sasso Faccin Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Marcia Silva Graudenz Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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Ana Luiza Maia Thyroid Unit, Endocrine Division, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

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cellularity or unsatisfying sampling precludes diagnosis in up to 20% of specimens, depending on the cytopathologist’s experience and skill [ 9 , 10 ]. Measurement of thyroglobulin in the washout of fine needle aspiration (FNA-Tg) has been used as an

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000479682
Volume/Issue:
Volume 6: Issue 6
Free access
Eijun Nishihara Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Nobuyuki Amino Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Takumi Kudo Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Kazuyoshi Kohsaka Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsuru Ito Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Shuji Fukata Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Mitsushige Nishikawa Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Hirotoshi Nakamura Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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Akira Miyauchi Kuma Hospital, Center for Excellence in Thyroid Care, Kobe, Japan

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, and positivity for thyroglobulin (Tg) hemagglutination antibodies and microsomal antibodies was tested [ 8 ]. However, the method was not sensitive enough to detect low levels of anti-thyroid antibodies. Therefore, earlier negative reports using Tg and

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000501033
Volume/Issue:
Volume 8: Issue 5
Open access
Mathieu Spaas Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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Brigitte Decallonne Department of Endocrinology and Internal Medicine, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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Annouschka Laenen Leuven Biostatistics and Statistical Bioinformatics Centre, Leuven, Belgium

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Jaak Billen Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium

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Sandra Nuyts Department of Radiation Oncology, KU Leuven – University of Leuven, University Hospitals Leuven, Leuven, Belgium

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normal thyroid tissue; secondly, RRA allows for serum thyroglobulin (Tg) to be used as a specific tumor marker and increases sensitivity of diagnostic whole-body iodine scintigraphy (WBS) in the follow-up, allowing early detection of recurrent or

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000489849
Volume/Issue:
Volume 7: Issue 4
Free access
Stefan Matei Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Julien Hospel Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Chantal Daumerie Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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Maria-Cristina Burlacu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgium

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-stimulating antibodies (TRAb) that are responsible for the major manifestations of hyperthyroidism, i.e. goiter and orbitopathy ( 2 ). Other thyroid antibodies, namely, thyroperoxidase (TPOAb) and thyroglobulin (TgAb) antibodies, are also frequently elevated in GD, but

Article Type:
Research Article
Collections:
Hyperthyroidism and thyrotoxicosis
DOI:
https://doi.org/10.1530/ETJ-23-0193
Volume/Issue:
Volume 12: Issue 6
Open access
Yuan Li Department of Endocrinology, Peking University First Hospital, Beijing, China

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Chenxu Zhao Department of Endocrinology, Peking University First Hospital, Beijing, China
Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang, China

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Keli Zhao Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China

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Nan Yu Department of Endocrinology, Peking University First Hospital, Beijing, China

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Yan Li Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China

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Yang Yu Department of Endocrinology, Peking University First Hospital, Beijing, China

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Yang Zhang Department of Endocrinology, Peking University First Hospital, Beijing, China

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Zhijing Song Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
College of Life Science, University of the Chinese Academy of Sciences, Beijing, China

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Youyuan Huang Department of Endocrinology, Peking University First Hospital, Beijing, China

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Guizhi Lu Department of Endocrinology, Peking University First Hospital, Beijing, China

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Ying Gao Department of Endocrinology, Peking University First Hospital, Beijing, China

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Junqing Zhang Department of Endocrinology, Peking University First Hospital, Beijing, China

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Xiaohui Guo Department of Endocrinology, Peking University First Hospital, Beijing, China

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Introduction Thyroglobulin antibodies (TgAb), frequently found in healthy individuals, are serological markers of both Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) [ 1 ]. In papillary thyroid carcinoma (PTC), the rate of TgAb

Article Type:
Research Article
DOI:
https://doi.org/10.1159/000507699
Volume/Issue:
Volume 10: Issue 2
Free access