Diana Borges Duarte
Diana Borges Duarte
Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal
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Vânia Benido Silva
Vânia Benido Silva
Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal
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Guilherme Assunção
Guilherme Assunção
Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal
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André Couto Carvalho
André Couto Carvalho
Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal
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Cláudia Freitas
Cláudia Freitas
Division of Endocrinology, Centro Hospitalar e Universitário do Porto, Porto, Portugal
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years, thyroid cancer has an excellent prognosis with a 5-year disease-specific survival rate of over 95% ( 2 ). Increased risk of non-thyroidal second primary malignancy (NTSPM) in DTC patients has been reported in several cancer epidemiological and
Jihwan Yoo
Jihwan Yoo
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
College of Medicine, Yonsei University, Seoul, Republic of Korea
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College of Medicine, Yonsei University, Seoul, Republic of Korea
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Hee Jun Kim
Hee Jun Kim
Department of Surgery, CHA Ilsan Medical Center, Cha University School of Medicine, Goyang-si, Republic of Korea
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Seok Mo Kim
Seok Mo Kim
Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Republic of Korea
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Hun Ho Park
Hun Ho Park
Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Seoul, Republic of Korea
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Introduction Patients with differentiated thyroid cancer (DTC) generally have a good prognosis, even in cases of stage IV disease. The 10-year disease-specific survival rate is 82.6%, which is longer than that among patients with other
Jan Jiskra
Jan Jiskra
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Jiří Horáček
Jiří Horáček
4th Department of Medicine, Faculty of Medicine, Charles University, University Hospital Hradec Králové, Czech Republic
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Sylvie Špitálníková
Sylvie Špitálníková
Department of Nuclear Medicine, District Hospital, Havlíčkův Brod, Czech Republic
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Jan Paleček
Jan Paleček
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Zdeňka Límanová
Zdeňka Límanová
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Jan Krátký
Jan Krátký
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Drahomíra Springer
Drahomíra Springer
Department of Clinical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Kristýna Žabková
Kristýna Žabková
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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Hana Vítková
Hana Vítková
3rd Department of Medicine, 1st Faculty of Medicine, Charles University, General University Hospital, Prague, Czech Republic
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supply are not available. After breast cancer, thyroid cancer is the second most common malignancy diagnosed during pregnancy ( 4 ). Approximately, 10% of thyroid cancers found during childbearing age occur during pregnancy or within the 12 months
Jiahui Wu
Jiahui Wu
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Xunyang Hu
Xunyang Hu
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Paula Seal
Paula Seal
EFW Radiology, Calgary, Alberta, Canada
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Parthiv Amin
Parthiv Amin
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Brendan Diederichs
Brendan Diederichs
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Mayfair Radiology, Calgary, Alberta, Canada
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Mayfair Radiology, Calgary, Alberta, Canada
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Ralf Paschke
Ralf Paschke
Section of Endocrinology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Departments of Medicine, Oncology, Pathology and Laboratory Medicine, Biochemistry and Molecular Biology, and Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
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Introduction Current postoperative follow-up (FU) and dynamic response to treatment (RTT) assessment of thyroid cancer primarily depends on postoperative neck ultrasound (POU) and thyroglobulin (Tg) determination ( 1 ). This FU strategy is
Alessia Cozzolino
Alessia Cozzolino
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Tiziana Filardi
Tiziana Filardi
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Ilaria Simonelli
Ilaria Simonelli
Service of Medical Statistics and Information Technology, Fatebenefratelli Foundation for Health Research and Education, Rome, Italy
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Giorgio Grani
Giorgio Grani
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Camilla Virili
Camilla Virili
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Ilaria Stramazzo
Ilaria Stramazzo
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Maria Giulia Santaguida
Maria Giulia Santaguida
Endocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, ‘Sapienza’ University of Rome, Latina, Italy
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Pietro Locantore
Pietro Locantore
Endocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy
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Massimo Maurici
Massimo Maurici
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
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Daniele Gianfrilli
Daniele Gianfrilli
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Andrea M Isidori
Andrea M Isidori
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Cosimo Durante
Cosimo Durante
Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy
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Carlotta Pozza
Carlotta Pozza
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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on behalf of TALENT Group
on behalf of TALENT Group
on behalf of TALENT Group
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, thyroid nodules in pediatric patients require a careful evaluation. According to the 2015 American Thyroid Association (ATA) Guidelines on Pediatric Thyroid nodules and Differentiated Thyroid Cancer, the evaluation and treatment of thyroid nodules in
Elisa Minaldi
Elisa Minaldi
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Virginia Cappagli
Virginia Cappagli
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Loredana Lorusso
Loredana Lorusso
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Laura Valerio
Laura Valerio
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Carlotta Giani
Carlotta Giani
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Matilde Viglione
Matilde Viglione
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Laura Agate
Laura Agate
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Eleonora Molinaro
Eleonora Molinaro
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Antonio Matrone
Antonio Matrone
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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Rossella Elisei
Rossella Elisei
Department of Clinical and Experimental Medicine, Unit of Endocrinology, University Hospital of Pisa, Via Paradisa, Pisa, Italy
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1 . Table 1 Clinical and pathological data of two groups of patients with advanced thyroid cancer treated with sorafenib and lenvatinib, respectively. Data are presented as n (%), mean ± s.d. or as median (IQR). Variables
Carla Colombo
Carla Colombo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Daniele Ceruti
Daniele Ceruti
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Massimiliano Succi
Massimiliano Succi
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Simone De Leo
Simone De Leo
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
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Matteo Trevisan
Matteo Trevisan
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Claudia Moneta
Claudia Moneta
Department of Biotechnology and Translational Medicine, University of Milan, Milan, Italy
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Laura Fugazzola
Laura Fugazzola
Endocrine Oncology Unit, Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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Introduction Tyrosine kinase inhibitors (TKIs) and target therapies are efficiently used in the treatment of progressive radioiodine-refractory differentiated thyroid cancer (RAI-R DTC) and advanced medullary thyroid cancer (MTC) ( 1 ). In
Valentina M. Drozd
Valentina M. Drozd
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Project Chernobyl, Brooklyn, New York, USA
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Project Chernobyl, Brooklyn, New York, USA
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Igor Branovan
Igor Branovan
Project Chernobyl, Brooklyn, New York, USA
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Nikolay Shiglik
Nikolay Shiglik
Project Chernobyl, Brooklyn, New York, USA
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Johannes Biko
Johannes Biko
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Christoph Reiners
Christoph Reiners
The International Fund “Help for patients with radiation-induced thyroid cancer ‘Arnica’”, Minsk, Belarus
Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Clinic and Polyclinic of Nuclear Medicine, University of Würzburg, Würzburg, Germany
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Introduction During the last 30 years, the incidence of differentiated thyroid cancer (DTC) has steadily increased worldwide, most markedly in France, Italy, the Republic of Korea, Australia, and the USA [ 1 - 8 ]. In the USA, DTC incidence is
Joachim N Nilsson
Joachim N Nilsson
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
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Jonathan Siikanen
Jonathan Siikanen
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Vincenzo Condello
Vincenzo Condello
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
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Kenbugul Jatta
Kenbugul Jatta
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Ravi Saini
Ravi Saini
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Christel Hedman
Christel Hedman
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Stockholms Sjukhem Foundation's Research and Development Department, Stockholm, Sweden
Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Catharina Ihre Lundgren
Catharina Ihre Lundgren
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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Department of Breast, Endocrine Tumours and Sarcoma, Karolinska University Hospital, Stockholm, Sweden
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C Christofer Juhlin
C Christofer Juhlin
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden
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Introduction Differentiated thyroid cancer is treated with surgery, and in cases of larger tumours or cervical lymph node metastases, additional hormone suppression and radioiodine therapy are given. Successful radioiodine therapy requires
Julia Ramalho Amalio da Silva Breder
Julia Ramalho Amalio da Silva Breder
Endocrinology Department, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Paulo Alonso Garcia Alves
Paulo Alonso Garcia Alves
Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Mario Lucio Araújo
Mario Lucio Araújo
Pathology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Barbara Pires
Barbara Pires
Endocrinology Department, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Priscila Valverde
Priscila Valverde
Pathology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Daniel Alves Bulzico
Daniel Alves Bulzico
Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Fernanda Andrade Accioly
Fernanda Andrade Accioly
Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Rossana Corbo
Rossana Corbo
Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Mario Vaisman
Mario Vaisman
Endocrinology Department, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Fernanda Vaisman
Fernanda Vaisman
Endocrinology Department, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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Endocrinology Department, Instituto Nacional do Cancer do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
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), although this finding has not been replicated in other studies ( 13 , 15 ). The role of puberty, sex, and sex hormone receptors in the pathogenesis of thyroid cancer and the relationship between these variables and tumor behavior remain controversial. To
