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Louise Knøsgaard Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

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Annebirthe Bo Hansen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Introduction The diagnosis and treatment of thyroid disease during pregnancy are debated and uncertainties exist regarding the assessment of maternal thyroid function in early pregnancy ( 1 , 2 ). During a normal pregnancy, several

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Dominik Spira Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Nikolaus Buchmann Department of Cardiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Marcus Dörr Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany

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Marcello R P Markus Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany

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Matthias Nauck German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

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Sabine Schipf Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Joachim Spranger Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Ilja Demuth Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Charité – Universitätsmedizin Berlin, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany

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Elisabeth Steinhagen-Thiessen Department of Endocrinology and Metabolism, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Henry Völzke German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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Till Ittermann Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

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with low thyroid function and prediabetes seem to be more likely to progress to type 2 diabetes compared to those with prediabetes and thyroid hormone levels in the reference range ( 6 ). The effects of subclinical hypo- or hyperthyroidism on glucose

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Peter Laurberg Department of Endocrinology, Aalborg Hospital, Aalborg

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Nils Knudsen Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark

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Stig Andersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Allan Carlé Department of Endocrinology, Aalborg Hospital, Aalborg

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Inge Bülow Pedersen Department of Endocrinology, Aalborg Hospital, Aalborg

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Jesper Karmisholt Department of Endocrinology, Aalborg Hospital, Aalborg

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clinical question in the thyroid and obesity field is the potential association between thyroid function and weight control, and the issue has been addressed in many studies. The present review discusses data suggesting that even rather small differences in

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Berta Soldevila Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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Inés Velasco Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Carla Muñoz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Yesika Díaz Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laia Egea-Cortés Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Laura Ferrer-Escopiñan Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Alejandra Pérez-Montes de Oca Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain

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Raquel Martínez-Mondejar Department of Obstetrics & Gynecology, Germans Trias i Pujol University Hospital, Badalona, Spain

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Jordi Casabona Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Health Department, Centre d’Estudis Epidemiològics sobre les Infeccions de Transmissió Sexual i Sida de Catalunya (CEEISCAT), Generalitat de Catalunya, Badalona, Spain

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Manel Puig-Domingo Department of Endocrinology & Nutrition. Germans Trias i Pujol University Hospital, Badalona, Spain
Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain
Department of Medicine, Autonomous University of Barcelona, Badalona, Spain

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thyroid function ( 5 ), including changes in hormonal metabolism and iodine absorption, inducing a dynamic regulation of the hypothalamic–pituitary–thyroid axis throughout pregnancy. For this reason, the measurement of thyroid function in healthy pregnant

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Tomohiro Kikuchi Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan
Department of Radiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan

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Shouhei Hanaoka Department of Radiology, The University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan

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Takahiro Nakao Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan

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Yukihiro Nomura Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan
Center for Frontier Medical Engineering, Chiba University, Yayoicho, Inage–ku, Chiba, Japan

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Takeharu Yoshikawa Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan

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Ashraful Alam Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan

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Harushi Mori Department of Radiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan

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Naoto Hayashi Department of Computational Diagnostic Radiology and Preventive Medicine, the University of Tokyo Hospital, Hongo, Bunkyo–ku, Tokyo, Japan

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thyroid accumulation is abnormal from an intra- and inter-observer perspective. In addition, research on the role of a high SUV in detecting abnormal thyroid function is lacking. Therefore, it is important to determine the SUV distribution in the normal

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Zohar Steinberg Ben-Zeev Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Marina Peniakov Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Clari Felszer Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Scott A Weiner Neonatal Intensive Care Unit, Ha’Emek Medical Center, Afula, Israel

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Avishay Lahad Pediatric Department A, Ha’Emek Medical Center, Afula, Israel

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Shlomo Almashanu The National Newborn Screening Program, Ministry of Health, Tel Hashomer, Ramat Gan, Israel

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Yardena Tenenbaum Rakover Consulting Medicine in Pediatric Endocrinology, Clalit Health Services, Afula, Israel
The Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel

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Introduction Maternal thyroid diseases are considered a risk factor for abnormal thyroid function at birth ( 1 , 2 , 3 , 4 , 5 ), as well as for long-term morbidity in offspring ( 1 , 6 , 7 , 8 , 9 , 10 , 11 ). Maternal

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Hongcheng Wei State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Quanquan Guan State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Qiurun Yu State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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Ting Chen Nanjing Maternity and Child Health Care Institute, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China

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Xu Wang Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China

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Yankai Xia State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China

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suggests that maternal thyroid function, acting as an essential biological indicator during pregnancy, plays a critical role in normal reproduction in several pathways, and thyroid dysfunction is among the most prevalent endocrine disorders during pregnancy

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Sylvie Hiéronimus Departments of Endocrinology, Diabetology and Reproductive Medicine

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Patricia Ferrari Departments of Biochemistry, University Hospital of Nice

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Jocelyn Gal Department of Biostatistics, University of Nice

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Frédéric Berthier Department of Biostatistics, University of Nice

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Stéphane Azoulay Institute of Chemistry, UMR 6001, University of Nice-Sophia-Antipolis

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André Bongain Gynaecology and Obstetrics, University Hospital of Nice

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Patrick Fénichel Departments of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France

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Françoise Brucker-Davis Departments of Endocrinology, Diabetology and Reproductive Medicine
Institut National de la Recherche Médicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France

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discretion of the physician. Data about the effect of such iodine prophylaxis on maternal and fetal thyroid function in pregnant women in areas of mild ID are scarce [ 9 , 10 ], and it remains to be assessed whether such supplementation is beneficial for

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Linda M. Thienpont Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Katleen Van Uytfanghe Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Sofie Van Houcke Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Gent

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Barnali Das Biochemistry and Immunology Laboratory, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India

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James D. Faix Stanford University School of Medicine, Palo Alto, Calif., Abbott Park, Ill., USA

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Finlay MacKenzie Birmingham Quality/UK NEQAS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Frank A. Quinn Medical and Scientific Affairs, Abbott Diagnostics, Abbott Laboratories, Abbott Park, Ill., USA

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Michael Rottmann Roche Diagnostics GmbH, Penzberg, Germany

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Annick Van den Bruel Department of Endocrinology, General Hospital Sint Jan, Bruges, Belgium

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laboratory tests include lipids, HbA1c, creatinine, and enzymes [ 4 , 5 , 6 , 7 ], but more are under development [ 8 , 9 , 10 , 11 ]. The IFCC Committee for Standardization of Thyroid Function Tests (C-STFT) aims at equivalence of laboratory testing for

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Natsuko Watanabe Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Jaeduk Yoshimura Noh Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Naomi Hattori Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Kenji Iwaku Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Nami Suzuki Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Ai Yoshihara Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Hidemi Ohye Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Miho Suzuki Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Masako Matsumoto Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Kei Endo Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Yo Kunii Department of Internal Medicine, Ito Hospital, Tokyo, Japan

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Gen Takagi Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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), the hsTnI level was normalized in 20 patients (80%), whereas in 5 patients (20%), the hsTnI level remained elevated despite normal thyroid function. A 53-year-old woman with Graves’ disease showed re-elevation of hsTnI and BNP levels, along with re

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